1. Natural Products
  2. Quinones

Quinones

Quinones represent a class of compounds that are widely distributed in nature. They are found in a wide variety of plants. They are also present in fungi, bacteria and in small amounts in animals. Quinones have a common basic structural pattern: an ortho or a para substituted dione conjugated either to an aromatic nucleus (benzoquinones) or to a condensed polycyclic aromatic system, such as Benzene quinones, Naphthalene quinones, Phenanthrenequinones and Anthraquinones. Quinones have potential biological activities for antioxidant, anti-inflammatory, antibiotic, anti-microbial, and anti-cancer activities. Anthraquinone derivatives, an important subclass of quinones show a wide array of pharmacological activities including laxative, anti-cancer, anti-inflammatory, anti-arthritic, anti-fungal, anti-bacterial, antiviral, anti-platelet aggregation and neuroprotective activity.

Quinones (154):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-15142
    Doxorubicin hydrochloride 25316-40-9 99.58%
    Doxorubicin (Hydroxydaunorubicin) hydrochloride, a cytotoxic anthracycline antibiotic, is an anti-cancer chemotherapy agent. Doxorubicin hydrochloride is a potent human DNA topoisomerase I and topoisomerase II inhibitor with IC50s of 0.8 μM and 2.67 μM, respectively. Doxorubicin hydrochloride reduces basal phosphorylation of AMPK and its downstream target acetyl-CoA carboxylase. Doxorubicin hydrochloride induces apoptosis and autophagy.
    Doxorubicin hydrochloride
  • HY-N0822
    Shikonin 517-89-5 99.80%
    Shikonin is a major component of a Chinese herbal medicine named zicao. Shikonin is a potent TMEM16A chloride channel inhibitor with an IC50 of 6.5 μM. Shikonin is a specific pyruvate kinase M2 (PKM2) inhibitor and can also inhibit TNF-α and NF-κB pathway. Shikonin decreases exosome secretion through the inhibition of glycolysis. Shikonin inhibits AIM2 inflammasome activation.
    Shikonin
  • HY-15230
    Geldanamycin 30562-34-6 99.78%
    Geldanamycin is a Hsp90 inhibitor with antimicrobial activity against many Gram-positive and some Gram-negative bacteria. Geldanamycin has anti-influenza virus H5N1 activities.
    Geldanamycin
  • HY-14393
    Emodin 518-82-1 99.39%
    Emodin (Frangula emodin), an anthraquinone derivative, is an anti-SARS-CoV compound. Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 (ACE2) interaction. Emodin inhibits casein kinase-2 (CK2). Anti-inflammatory and anticancer effects. Emodin is a potent selective 11β-HSD1 inhibitor with the IC50 of 186 and 86 nM for human and mouse 11β-HSD1, respectively. Emodin ameliorates metabolic disorder in diet-induced obese mice.
    Emodin
  • HY-B0332
    Menadione 58-27-5 98.07%
    Menadione, a synthetic naphthoquinone, can be converted to active vitamin K2 in vivo.
    Menadione
  • HY-N7719
    Oosporein 475-54-7
    Oosporein is a red crystalline metabolite produced by a toxin-producing strain of Chaetomium trilaterale. Chaetomium trilaterale is isolated from moldy Peanuts. Oosporein inhibits plant growth and produces phytotoxic effects.
    Oosporein
  • HY-N2853
    D-α-Tocopherylquinone 7559-04-8 ≥98.0%
    D-α-Tocopherylquinone (α-Tocopherylquinone) is a quinone, can be isolated from Phaeodactylum tricornutum. D-α-Tocopherylquinone is a oxidation product of α-Tocopherol (vitamin E). D-α-Tocopherylquinone can act as an anticoagulant and as an antioxidant.
    D-α-Tocopherylquinone
  • HY-N7962
    Cornoside 40661-45-8
    Cornoside is a phenolic glycoside and has inhibitory effect on rat lens aldose reductase (AR) with an IC50 of 150 μM.
    Cornoside
  • HY-N0111
    Coenzyme Q10 303-98-0 ≥98.0%
    Coenzyme Q10 is an essential cofactor of the electron transport chain and a potent antioxidant agent.
    Coenzyme Q10
  • HY-N0174
    Cryptotanshinone 35825-57-1 98.69%
    Cryptotanshinone is a natural compound extracted from the root of Salvia miltiorrhiza Bunge that shows antitumor activities. Cryptotanshinone inhibits STAT3 with an IC50 of 4.6 μM.
    Cryptotanshinone
  • HY-13555
    β-Lapachone 4707-32-8 99.85%
    β-Lapachone (ARQ-501;NSC-26326) is a naturally occurring O-naphthoquinone, acts as a topoisomerase I inhibitor, and induces apoptosis by inhibiting cell cycle progression.
    β-Lapachone
  • HY-N0105
    Rhein 478-43-3 99.73%
    Rhein is a lipophilic anthraquinone extensively found in medicinal herbs, and has many pharmacological effects, including epatoprotective, nephroprotective, anti-inflammatory, antioxidant, anticancer, and antimicrobial activities.
    Rhein
  • HY-B2156
    Menaquinone-4 863-61-6 99.81%
    Menaquinone-4 is a vitamin K, used as a hemostatic agent, and also a adjunctive therapy for the pain of osteoporosis.
    Menaquinone-4
  • HY-N0135
    Tanshinone IIA 568-72-9 99.71%
    Tanshinone IIA (Tan IIA) is one of the main compositions in the root of red-rooted salvia. Tanshinone IIA may suppress angiogenesis by targeting the protein kinase domains of VEGF/VEGFR2.
    Tanshinone IIA
  • HY-N0283
    Diacerein 13739-02-1 98.78%
    Diacerein (Diacerhein), a interleukin-1 beta inhibitor, is a slow-acting medicine of the class anthraquinone used to treat joint diseases.
    Diacerein
  • HY-N2306A
    Aclacinomycin A hydrochloride 75443-99-1
    Aclacinomycin A hydrochloride (Aclarubicin hydrochloride), a fluorescent molecule and the first described non-peptidic inhibitor showing discrete specificity for the CTRL (chymotrypsin-like) activity of the 20S proteasome. Aclacinomycin A hydrochloride is also a dual inhibitor of topoisomerase I and II. An effective anthracycline chemotherapeutic agent for hematologic cancers and solid tumors.
    Aclacinomycin A hydrochloride
  • HY-N0684
    Vitamin K1 84-80-0 ≥98.0%
    Vitamin K1 a naturally occurring vitamin required for blood coagulation and bone and vascular metabolism.
    Vitamin K1
  • HY-N0360
    Dihydrotanshinone I 87205-99-0 99.22%
    Dihydrotanshinone I is a natural compound extracted from Salvia miltiorrhiza Bunge which has been widely used for treating cardiovascular diseases. Dihydrotanshinone I exhibits entry-blocking effect for MERS-CoV.
    Dihydrotanshinone I
  • HY-N0108
    Physcion 521-61-9 99.10%
    Physcion (Parietin) is an anthraquinone isolated from traditional Chinese medicine Radix et Rhizoma Rhei, acts as an inhibitor of 6-phosphogluconate dehydrogenase, with an IC50 and a Kd of 38.5 μM and 26.0 μM, respectively. Physcion (Parietin) exhibits laxative, hepatoprotective, anti-inflammatory, anti-microbial, anti-proliferative and anti-tumor effects.
    Physcion
  • HY-N1497
    Plumbagin 481-42-5 99.65%
    Plumbagin (2-Methyljuglone) is a naphthoquinone isolated from Plumbago zeylanica L, exhibits anticancer and antiproliferative activities.
    Plumbagin