1. PI3K/Akt/mTOR Anti-infection Apoptosis Autophagy
  2. mTOR Influenza Virus Apoptosis Autophagy
  3. Aloe emodin

Aloe emodin  (Synonyms: Rhabarberone; 3-Hydroxymethylchrysazine)

Cat. No.: HY-N0189 Purity: 98.32%
COA Handling Instructions

Aloe emodin (Rhabarberone) is a natural hydroxyanthraquinone with antitumor activities. aloe-emodin can bind with mTORC2 and inhibit its kinase activity. Aloe emodin exerts antiproliferation effects and induces cellular apoptosis. Aloe emodin also exhibits antiviral activity that against influenza A virus.

For research use only. We do not sell to patients.

Aloe emodin Chemical Structure

Aloe emodin Chemical Structure

CAS No. : 481-72-1

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10 mM * 1 mL in DMSO
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Description

Aloe emodin (Rhabarberone) is a natural hydroxyanthraquinone with antitumor activities. aloe-emodin can bind with mTORC2 and inhibit its kinase activity. Aloe emodin exerts antiproliferation effects and induces cellular apoptosis[1]. Aloe emodin also exhibits antiviral activity that against influenza A virus[2].

IC50 & Target[1]

mTORC2

 

In Vitro

Aloe emodin (0-15 μM; 24-96 h) inhibits PC3 cell proliferation in a dose-dependent manner[1].
Aloe emodin (0-15 μM; 24 h) inhibits the activation of mTORC2 downstream substrates, Akt and PKCα. Aloe emodin could bind with mTORC2 in cells and inhibit its kinase activity[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: PC3 cells
Concentration: 0 μM, 2.5 μM, 5 μM, 10 μM or 15 μM
Incubation Time: 24 h, 48 h, 72 h or 96 h
Result: Suppressed proliferation and anchorage-independent growth of PC3 cells.

Western Blot Analysis[1]

Cell Line: PC3 cells
Concentration: 0 μM, 2.5 μM, 5 μM, 10 μM or 15 μM
Incubation Time: 24 h
Result: Inhibited the activation of the downstream substrates of mTORC2, Akt and PKCα.
In Vivo

Aloe emodin (10-50 mg/kg) suppresses tumor growth by inhibiting mTOR complex2 activity[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Athymic nude mice (BALB/c nude mouse, 6 weeks old)[1]
Dosage: 10 mg/kg, 50 mg/kg (20% PEG400 in autoclaved PBS)
Administration: Intraperitoneal injection, five times per week; for 28 days
Result: Exhibited tumor suppression effects in vivo in an athymic nude mouse model.
Molecular Weight

270.24

Formula

C15H10O5

CAS No.
Appearance

Solid

Color

Brown to orange

SMILES

O=C1C2=C(C=CC=C2O)C(C3=CC(CO)=CC(O)=C13)=O

Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : ≥ 20.83 mg/mL (77.08 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.7004 mL 18.5021 mL 37.0041 mL
5 mM 0.7401 mL 3.7004 mL 7.4008 mL
10 mM 0.3700 mL 1.8502 mL 3.7004 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: 2.08 mg/mL (7.70 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: 2.08 mg/mL (7.70 mM); Suspended solution; Need ultrasonic

*All of the co-solvents are available by MedChemExpress (MCE).
Purity & Documentation

Purity: 98.32%

References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Aloe emodin
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HY-N0189
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