1. Apoptosis Anti-infection Neuronal Signaling Epigenetics TGF-beta/Smad Metabolic Enzyme/Protease Cell Cycle/DNA Damage
  2. Apoptosis Influenza Virus Antibiotic Monoamine Oxidase PKC Cytochrome P450 Dopamine β-hydroxylase Reverse Transcriptase Telomerase
  3. Hypericin

Hypericin 

Cat. No.: HY-N0453 Purity: ≥98.0%
COA Handling Instructions

Hypericin is a naturally occurring substance found in Hyperlcurn perforatum L. Hypericin is an inhibitor of PKC (protein kinase C), MAO (monoaminoxidase), dopamine-beta-hydroxylase, reverse transcriptase, telomerase and CYP (cytochrome P450). Hypericin shows antitumor, antiviral, antidepressive activities, and can induce apoptosis.

For research use only. We do not sell to patients.

Hypericin Chemical Structure

Hypericin Chemical Structure

CAS No. : 548-04-9

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
USD 176 In-stock
Solution
10 mM * 1 mL in DMSO USD 176 In-stock
Solid
1 mg USD 66 In-stock
5 mg USD 158 In-stock
10 mg USD 238 In-stock
25 mg USD 462 In-stock
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Based on 2 publication(s) in Google Scholar

Other Forms of Hypericin:

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Description

Hypericin is a naturally occurring substance found in Hyperlcurn perforatum L. Hypericin is an inhibitor of PKC (protein kinase C), MAO (monoaminoxidase), dopamine-beta-hydroxylase, reverse transcriptase, telomerase and CYP (cytochrome P450). Hypericin shows antitumor, antiviral, antidepressive activities, and can induce apoptosis[1][2][3].

In Vitro

Hypericin (0.25-4 μM; 24 h) inhibits the growth of fibroblasts (Fb), melanocytes (Mc), and keratinocytes (Kc)[2].
Hypericin (3 μM; 24 h) treatment can induce cells apoptosis[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[2]

Cell Line: Fibroblasts (Fb), melanocytes (Mc), and keratinocytes (Kc)
Concentration: 0.25 μM; 0.5 μM; 1 μM; 2 μM; 3 μM; 4 μM
Incubation Time: 24 hours
Result: Showed the LD50 for Fb and Mc at 1.75 μM and 3.5 μM, respectively, and for Kc at a greater dose than 4 μM.

Apoptosis Analysis[2]

Cell Line: Fibroblasts (Fb), melanocytes (Mc), and keratinocytes (Kc)
Concentration: 3 μM
Incubation Time: 24 hours
Result: Showed a significant (p<0.001) early apoptotic Fb population (64%), and a smaller, significant (p<0.05) early apoptotic Mc population (20%).
In Vivo

Hypericin (Intravenous injection; 10 mg/kg; once) treatment delays tumor growth[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 18-20 week-old female BALB/c mice injected with CT26 carcinomas[3]
Dosage: 10 mg/kg
Administration: Intravenous injection; 10 mg/kg; once
Result: Showed a four times delayed tumor growth compared to the control groups.
Clinical Trial
Molecular Weight

504.44

Formula

C30H16O8

CAS No.
Appearance

Solid

Color

Brown to black

SMILES

O=C1C2=C(O)C=C(O)C3=C2C4=C(C5=C6C(O)=CC(C)=C5C7=C4C1=C(O)C=C7C)C8=C3C(O)=CC(O)=C8C6=O

Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (495.60 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9824 mL 9.9120 mL 19.8240 mL
5 mM 0.3965 mL 1.9824 mL 3.9648 mL
10 mM 0.1982 mL 0.9912 mL 1.9824 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: 2.08 mg/mL (4.12 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: 2.08 mg/mL (4.12 mM); Clear solution; Need ultrasonic

*All of the co-solvents are available by MedChemExpress (MCE).
Purity & Documentation

Purity: ≥98.0%

References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Hypericin
Cat. No.:
HY-N0453
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