548-04-9
Chemical Structure
Hypericin
- CAS No.: 548-04-9
- Formula:C30H16O8
- Molecular Weight:504.44
IUPAC Name: 1,3,4,6,8,13-hexahydroxy-10,11-dimethylphenanthro[1,10,9,8-opqra]perylene-7,14-dione
InChIKey: BTXNYTINYBABQR-UHFFFAOYSA-N
SMILES: O=C1C2=C(O)C=C(O)C3=C2C4=C(C5=C6C(O)=CC(C)=C5C7=C4C1=C(O)C=C7C)C8=C3C(O)=CC(O)=C8C6=O
Biological Activity: Hypericin is a naturally occurring substance found in Hyperlcurn perforatum L. Hypericin is an inhibitor of PKC (protein kinase C), MAO (monoaminoxidase), dopamine-beta-hydroxylase, reverse transcriptase, telomerase and CYP (cytochrome P450). Hypericin shows antitumor, antiviral, antidepressive activities, and can induce apoptosis[1][2][3].
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Hypericin | 98.79% | Hypericin is a naturally occurring substance found in Hyperlcurn perforatum L. Hypericin is an inhibitor of PKC (protein kinase C), MAO (monoaminoxidase), dopamine-beta-hydroxylase, reverse transcriptase, telomerase and CYP (cytochrome P450). Hypericin shows antitumor, antiviral, antidepressive activities, and can induce apoptosis. | ||||||||||||||||||||
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Hypericin (Standard) | 98.07% | Hypericin (Standard) is the analytical standard of Hypericin. This product is intended for research and analytical applications. Hypericin is a naturally occurring substance found in Hyperlcurn perforatum L. Hypericin is an inhibitor of PKC (protein kinase C), MAO (monoaminoxidase), dopamine-beta-hydroxylase, reverse transcriptase, telomerase and CYP (cytochrome P450). Hypericin shows antitumor, antiviral, antidepressive activities, and can induce apoptosis. | ||||||||||||||||||||
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Hypericin-d2 | 94.68% | Hypericin-d2 is deuterium labeled Hypericin. | ||||||||||||||||||||
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Hypericin-d10 | 95.32% | Hypericin-d10 is the deuterium labeled Hypericin. Hypericin is a photosensitive antiviral with anticancer and antidepressant agent derived from Hypericum perforatum. It can inhibit tyrosine kinases with IC50 of 7.5 μM. | ||||||||||||||||||||
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Similarity Score 0.88
HY-N0685Pseudohypericin -
Similarity Score 0.79
HY-N4139RProtohypericin (Standard) -
Similarity Score 0.51
HY-N14989Fluostatin A -
Similarity Score 0.49
HY-N19700Calphostin D -
Similarity Score 0.48
HY-116157Pyranthrone -
Similarity Score 0.47
HY-N14989AFluostatin A sodium -
Similarity Score 0.46
HY-W020768Fullerene-C60 -
Similarity Score 0.45
HY-147059Dieckol -
Similarity Score 0.45
![Tribenzo[a,e,i]cyclododecene-2,3,8,9,14,15-hexol,5,6,11,12,17,18-hexadehydro- Chemical Structure](//file.medchemexpress.com/product_pic/hy-w543270.gif)
HY-W543270Tribenzo[a,e,i]cyclododecene-2,3,8,9,14,15-hexol,5,6,11,12,17,18-hexadehydro- -
Explore the MedChemAI to find more analogs
![Tribenzo[a,e,i]cyclododecene-2,3,8,9,14,15-hexol,5,6,11,12,17,18-hexadehydro- Chemical Structure](http://file.medchemexpress.com/product_pic/hy-w543270.gif)
References
- [1]. A Kubin, et al. Hypericin--the facts about a controversial agent. Curr Pharm Des. 2005;11(2):233-53. [Content Brief]
- [2]. A Popovic, et al. Differential susceptibility of primary cultured human skin cells to hypericin PDT in an in vitro model. J Photochem Photobiol B. 2015 Aug;149:249-56. [Content Brief]
- [3]. Renata Sanovic, et al. Low dose hypericin-PDT induces complete tumor regression in BALB/c mice bearing CT26 colon carcinoma. Photodiagnosis Photodyn Ther. 2011 Dec;8(4):291-6. [Content Brief]
