Signaling Pathway

Dopamine β-hydroxylase

Dopamine β-hydroxylase

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Dopamine beta-hydroxylase (Dopamine beta-monooxygenase) is an enzyme that in humans is encoded by the DBH gene. Dopamine beta-monooxygenase catalyzes the chemical reaction with 3 substrates of 3,4-dihydroxyphenethylamine, ascorbate, and O2, whereas its 3 products are noradrenaline, dehydroascorbate, and H2O. Dopamine beta-hydroxylase belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. Dopamine beta-hydroxylase participates in tyrosine metabolism. It has 3 cofactors: copper, PQQ, and Fumarate. Dopamine beta-hydroxylase is in the catecholamine biosynthetic pathway. Dopamine beta-hydroxylase has been shown to be associated with decision making and addictive behaviors such as alcohol and smoking, attention deficit hyperactivity disorder, and also with neurological diseases such as Schizophrenia and Alzheimer's.

Dopamine β-hydroxylase Inhibitors & Modulators (2)

Product Name Catalog No. Brief Description
Nepicastat

HY-13289

Nepicastat (SYN117; RS-25560-197) is a dopamine beta-hydroxylase inhibitor with IC50 of 8.5 ± 0.8 and 9.0 ± 0.8 nM for bovine and human, respectively.

Nepicastat hydrochloride

HY-13289A

Nepicastat Hcl(SYN117 Hcl; RS-25560-197 Hcl) is a dopamine beta-hydroxylase inhibitor with IC50 of 8.5 ± 0.8 and 9.0 ± 0.8 nM for bovine and human, respectively.