1. Membrane Transporter/Ion Channel
  2. P-glycoprotein
    BCRP

Zamicastat 

Cat. No.: HY-106004
Handling Instructions

Zamicastat is a concentration-dependent dual P-gp and BCRP inhibitor with IC50 values of 73.8±7.2 μM and 17.0±2.7 μM, respectively.

For research use only. We do not sell to patients.

Zamicastat Chemical Structure

Zamicastat Chemical Structure

CAS No. : 1080028-80-3

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Customer Review

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

Zamicastat is a concentration-dependent dual P-gp and BCRP inhibitor with IC50 values of 73.8±7.2 μM and 17.0±2.7 μM, respectively.

IC50 & Target

IC50: 73.8±7.2 μM (P-gp), 17.0±2.7 μM (BCRP)[1]

In Vitro

Zamicastat is a concentration-dependent dual P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP) inhibitor with IC50 values of 73.8±7.2 μM and 17.0±2.7 μM. Zamicastat also reversibly inhibits dopamine β-hydroxylase (DBH) without effect in brain tissue[1].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4908 mL 12.4542 mL 24.9085 mL
5 mM 0.4982 mL 2.4908 mL 4.9817 mL
10 mM 0.2491 mL 1.2454 mL 2.4908 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

401.47

Formula

C₂₁H₂₁F₂N₃OS

CAS No.

1080028-80-3

SMILES

S=C1N([[email protected]@H]2CC3=CC(F)=CC(F)=C3OC2)C(CCNCC4=CC=CC=C4)=CN1

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2

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Product Name:
Zamicastat
Cat. No.:
HY-106004
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Zamicastat

Cat. No.: HY-106004