1. Metabolic Enzyme/Protease
  2. Dopamine β-hydroxylase
  3. Nepicastat hydrochloride

Nepicastat hydrochloride (Synonyms: SYN-117 hydrochloride; RS-25560-197 hydrochloride)

Cat. No.: HY-13289A Purity: 99.98%
Handling Instructions

Nepicastat hydrochloride (SYN-117 hydrochloride; RS-25560-197 hydrochloride) is a dopamine beta-hydroxylase inhibitor with IC50 of 8.5 ± 0.8 and 9.0 ± 0.8 nM for bovine and human, respectively.

For research use only. We do not sell to patients.

Nepicastat hydrochloride Chemical Structure

Nepicastat hydrochloride Chemical Structure

CAS No. : 170151-24-3

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 92 In-stock
Estimated Time of Arrival: December 31
5 mg USD 84 In-stock
Estimated Time of Arrival: December 31
10 mg USD 144 In-stock
Estimated Time of Arrival: December 31
50 mg USD 648 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Other Forms of Nepicastat hydrochloride:

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Description

Nepicastat hydrochloride (SYN-117 hydrochloride; RS-25560-197 hydrochloride) is a dopamine beta-hydroxylase inhibitor with IC50 of 8.5 ± 0.8 and 9.0 ± 0.8 nM for bovine and human, respectively. IC50 value: 8.5/9.0 nM(bovine/human dopamine beta-hydroxylase) Dopamine beta-hydroxylase is an enzyme that catalyzes the conversion of dopamine to norepinephrine. Nepicastat (SYN117; RS-25560-197) has been studied as a possible treatment for congestive heart failure, and appears to be well tolerated as such.

Clinical Trial
Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 6 mg/mL (18.08 mM; Need ultrasonic)

H2O : 2 mg/mL (6.03 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0138 mL 15.0689 mL 30.1377 mL
5 mM 0.6028 mL 3.0138 mL 6.0275 mL
10 mM 0.3014 mL 1.5069 mL 3.0138 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 0.6 mg/mL (1.81 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 0.6 mg/mL (1.81 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 0.6 mg/mL (1.81 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Molecular Weight

331.81

Formula

C₁₄H₁₆ClF₂N₃S

CAS No.

170151-24-3

SMILES

FC1=CC(F)=C2CC[[email protected]@H](CC2=C1)N3C(CN)=CNC3=S.Cl

Shipping

Room temperature in continental US; may vary elsewhere

Purity: 99.98%

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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2

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Product Name:
Nepicastat hydrochloride
Cat. No.:
HY-13289A
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Nepicastat hydrochloride

Cat. No.: HY-13289A