(R)-Nepicastat hydrochloride
(R)-Nepicastat hydrochloride is the isomer of Nepicastat (HY-13289). Nepicastat (SYN117) is a selective，potent，and orally active inhibitor of dopamine-beta-hydroxylase. Nepicastat (SYN117) produces concentration-dependent inhibition of bovine (IC50=8.5 nM) and human (IC50=9 nM) dopamine-beta-hydroxylase. Nepicastat (SYN117) can cross the blood-brain barrier (BBB).
For research use only. We do not sell to patients.
- CAS No.: 195881-94-8
- Formula: C14H16ClF2N3S
- Molecular Weight:331.81
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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HY-13289A
Nepicastat hydrochloride
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HY-12347
Ro 61-8048
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HY-B1836
Meldonium
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HY-13055
Telotristat etiprate
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HY-15893
DMOG
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HY-B1836R
Meldonium (Standard)
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HY-15893R
DMOG (Standard)
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HY-13055B
Telotristat
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HY-13986
Merimepodib
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HY-12347R
Ro 61-8048 (Standard)
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HY-N0137
Tetrahydropapaverine hydrochloride
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HY-15893G
DMOG (GMP)
Biological Activity
Chemical Information
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CAS No. 195881-94-8
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Molecular Weight 331.81
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Formula C14H16ClF2N3S
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SMILES
S=C1NC=C(CN)N1[C@H]2CC3=C(C(F)=CC(F)=C3)CC2.Cl
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Synonyms
(R)-SYN117 hydrochloride; (R)-RS-25560-197 hydrochloride; RS-25560-198 hydrochloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Beliaev A, et al. Synthesis and biological evaluation of novel, peripherally selective chromanyl imidazolethione-based inhibitors of dopamine beta-hydroxylase.J Med Chem. 2006 Feb 9;49(3):1191-7. [Content Brief]
[2]. Stanley WC, et al. Catecholamine modulatory effects of nepicastat (RS-25560-197), a novel, potent and selective inhibitor of dopamine-beta-hydroxylase.Br J Pharmacol. 1997 Aug;121(8):1803-9. [Content Brief]
[3]. Stanley WC, et al. Cardiovascular effects of nepicastat (RS-25560-197), a novel dopamine beta-hydroxylase inhibitor. J Cardiovasc Pharmacol. 1998 Jun;31(6):963-70. [Content Brief]
[4]. Sabbah HN, et al. Effects of dopamine beta-hydroxylase inhibition with nepicastat on the progression of left ventricular dysfunction and remodeling in dogs with chronic heart failure. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(R)-Nepicastat hydrochloride Related Classifications
HY-13289B Related Classifications
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