760173-05-5
760173-05-5
Chemical Structure
Etamicastat
Synonym(s): BIA 5-453
- CAS No.: 760173-05-5
- Formula:C14H15F2N3OS
- Molecular Weight:311.35
IUPAC Name: (R)-5-(2-aminoethyl)-1-(6,8-difluorochroman-3-yl)-1,3-dihydro-2H-imidazole-2-thione
InChIKey: CWWWTTYMUOYSQA-LLVKDONJSA-N
SMILES: S=C1NC=C(CCN)N1[C@H]2COC3=C(C=C(F)C=C3F)C2
Biological Activity: Etamicastat (BIA 5-453) is a potent and reversible dopamine-β-hydroxylase (DBH) inhibitor with an IC50 value of 107 nM[1]. Etamicastat can be used in the research of cardiovascular diseases[2].
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Etamicastat | Etamicastat (BIA 5-453) is a potent and reversible dopamine-β-hydroxylase (DBH) inhibitor with an IC50 value of 107 nM. Etamicastat can be used in the research of cardiovascular diseases. | |||||||||||||||||||||
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References
- [1]. Loureiro AI, et al. Etamicastat, a new dopamine-ß-hydroxylase inhibitor, pharmacodynamics and metabolism in rat. Eur J Pharmacol. 2014 Oct 5;740:285-94. [Content Brief]
- [2]. ManuelVaz-da-Silva, et al. Cardiac safety profile of etamicastat, a novel peripheral selective dopamine-β-hydroxylase inhibitor in non-human primates, human young and elderly healthy volunteers and hypertensive patients. IJC Metabolic & Endocrine. 2015 Ju
Keywords
