1. Metabolic Enzyme/Protease
  2. Dopamine β-hydroxylase

Etamicastat (Synonyms: BIA 5-453)

Cat. No.: HY-14838
Handling Instructions

Etamicastat (BIA 5-453) is a potent and reversible peripheral dopamine-β-hydroxylase (DβH) inhibitor.

For research use only. We do not sell to patients.

Etamicastat Chemical Structure

Etamicastat Chemical Structure

CAS No. : 760173-05-5

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  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

Etamicastat (BIA 5-453) is a potent and reversible peripheral dopamine-β-hydroxylase (DβH) inhibitor[1].

IC50 & Target

Dopamine-β-hydroxylase (DβH)[1]

In Vivo

Upon intraperitoneal administration to NMRi mice, Etamicastat (100 mg/ kg) leads to a significant reduction of noradrenaline levels (36% control) in heart with concomitant increasing in dopamine levels (850% of control)[2].
Etamicastat (50 mg/kg) is rapidly absorbed into the systemic circulation reaching a maximum concentration at 4 h post-administration, representing 29% of total Etamicastat and quantified metabolites, using AUC0-t as a measure of systemic exposure[2].

References
Molecular Weight

311.35

Formula

C₁₄H₁₅F₂N₃OS

CAS No.

760173-05-5

SMILES

S=C1NC=C(CCN)N1[[email protected]]2COC3=C(C=C(F)C=C3F)C2

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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This equation is commonly abbreviated as: C1V1 = C2V2

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C1   V1   C2   V2

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Product Name:
Etamicastat
Cat. No.:
HY-14838
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Etamicastat

Cat. No.: HY-14838