14901-16-7
14901-16-7
Chemical Structure
U-14624
- CAS No.: 14901-16-7
- Formula:C10H9N3S2
- Molecular Weight:235.33
IUPAC Name: 1-phenyl-3-(thiazol-2-yl)thiourea
InChIKey: GCZZOZBWAZHCAN-UHFFFAOYSA-N
SMILES: S=C(NC1=CC=CC=C1)NC2=NC=CS2
Biological Activity: U-14624 is a potent and orally active dopamine beta-hydroxylase inhibitor. U-14624 suppresses the activities of aminopyrine N-demethylase, aniline hydroxylase and p-nitroanisole O-demethylase enzymes[1][2].
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U-14624 | 99.67% | U-14624 is a potent and orally active dopamine beta-hydroxylase inhibitor. U-14624 suppresses the activities of aminopyrine N-demethylase, aniline hydroxylase and p-nitroanisole O-demethylase enzymes. | ||||||||||||||||||||
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References
- [1]. Von Voigtlander PF, et al. Behavioral and brain catecholamine depleting actions of U-14,624, an inhibitor of dopamine beta-hydroxylase. Proc Soc Exp Biol Med. 1970 Mar;133(3):817-20. [Content Brief]
- [2]. Smith JR, et al. Effect of the catecholamine-depleting agent 1-phenyl-3-(2-thiazolyl)-2-thiourea (U-14,624) on drug metabolism in the rat. Biochem Pharmacol. 1980 Sep 15;29(18):2425-30. [Content Brief]
Keywords
