2. Neuronal Signaling Others
  3. α-synuclein Environmental Pollutants
  4. 6PPD-Q

6PPD-Q (6PPD-Quinone) is an environmental pollutant that can be detected in human urine and is widely present in the environment. 6PPD-Q targets and binds to CNR2, CNR1, AA2AR, LCAT, and TRPA1, with CNR2 exhibiting the highest binding affinity, potentially acting as a CNR2 receptor agonist to activate cannabinoid receptors. 6PPD-Q induces intestinal inflammation and barrier damage by disrupting mitochondrial function, reducing neuronal glycolysis metabolites and TCA cycle intermediates, and exacerbating α-synuclein (α-syn) aggregation. 6PPD-Q is applicable in research on environmental toxicology, neurodegenerative diseases, and inflammation-related disorders.

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CAS No. : 2754428-18-5

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Based on 7 publication(s) in Google Scholar

Other Forms of 6PPD-Q:

6PPD-Q Related Antibodies

Top Publications Citing Use of Products

    6PPD-Q purchased from MedChemExpress. Usage Cited in: Environ Pollut. 2026 Apr 1:394:127701.  [Abstract]

    6-Phenylenediamine quinone (6PPD-Q, intraperitoneal injections, 4 mg/kg, every 4 days for 28 days) resulted in substantial damage to testicular tissue in 6-week-old male BALB/c mice.

    6PPD-Q purchased from MedChemExpress. Usage Cited in: Environ Pollut. 2026 Apr 1:394:127701.  [Abstract]

    6-Phenylenediamine quinone (6PPD-Q, intraperitoneal injections, 4 mg/kg, every 4 days for 28 days) exhibited a significant reduction in body weight. However, the testicular index remained unchanged in 6-week-old male BALB/c mice.

    6PPD-Q purchased from MedChemExpress. Usage Cited in: Environ Pollut. 2026 Apr 1:394:127701.  [Abstract]

    6-Phenylenediamine quinone (6PPD-Q, intraperitoneal injections, 4 mg/kg, every 4 days for 28 days) reduced sperm concentration in the tubules in 6-week-old male BALB/c mice.

    6PPD-Q purchased from MedChemExpress. Usage Cited in: Environ Pollut. 2026 Apr 1:394:127701.  [Abstract]

    6-Phenylenediamine quinone (6PPD-Q, intraperitoneal injections, 4 mg/kg, every 4 days for 28 days) reduced SOD activity and increased MDA levels in the testicular tissue of 6-week-old male BALB/c mice.

    6PPD-Q purchased from MedChemExpress. Usage Cited in: Environ Pollut. 2026 Apr 1:394:127701.  [Abstract]

    6-Phenylenediamine quinone (6PPD-Q, intraperitoneal injections, 4 mg/kg, every 4 days for 28 days) decreased levels of Bcl-2 (p < 0.01) alongside increased levels of Bax and cleaved caspase-3 (p < 0.01) in the 6PPD-Q group.

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    α-synuclein α-synuclein Aggregation α-synuclein/CHMP2B

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    Description

    6PPD-Q (6PPD-Quinone) is an environmental pollutant that can be detected in human urine and is widely present in the environment. 6PPD-Q targets and binds to CNR2, CNR1, AA2AR, LCAT, and TRPA1, with CNR2 exhibiting the highest binding affinity, potentially acting as a CNR2 receptor agonist to activate cannabinoid receptors. 6PPD-Q induces intestinal inflammation and barrier damage by disrupting mitochondrial function, reducing neuronal glycolysis metabolites and TCA cycle intermediates, and exacerbating α-synuclein (α-syn) aggregation. 6PPD-Q is applicable in research on environmental toxicology, neurodegenerative diseases, and inflammation-related disorders[1].

    IC50 & Target

    α-synuclein Aggregation

     

    In Vitro

    6PPD-Q (10 nM, 100 nM, 7 days) increases α-syn aggregation in primary dopaminergic neurons, enhances α-syn PFF-induced p-α-synSer129 expression, and promotes its accumulation in mitochondria[2].
    6PPD-Q (10 nM, 100 nM, 7 days) reduces mitochondrial respiration in primary dopaminergic neurons, particularly under α-syn PFF (α-synuclein preformed fibrils) treatment conditions[2].
    6PPD-Q (10 nM, 100 nM, 7 days) decreases glycolysis metabolites and alters TCA cycle intermediates in primary dopaminergic neurons, leading to a reduction in glycolysis metabolites (e.g., fructose-6-phosphate, pyruvate) and TCA cycle intermediates (e.g., citrate, α-ketoglutarate)[2].
    6PPD-Q (10 nM, 100 nM, 48 hours) does not exhibit significant cytotoxicity in primary dopaminergic neurons[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    6PPD-Q Related Antibodies

    Cell Viability Assay[2]

    Cell Line: Primary dopaminergic neurons
    Concentration: 10 nM, 100 nM
    Incubation Time: 48 hours
    Result: Did not exhibit apparent cytotoxicity.

    Western Blot Analysis[2]

    Cell Line: Primary dopaminergic neurons
    Concentration: 10 nM, 100 nM
    Incubation Time: 7 days
    Result: Significantly increased Triton X-100-insoluble α-synuclein (α-syn) protein levels.

    Immunofluorescence[2]

    Cell Line: Primary dopaminergic neurons
    Concentration: 10 nM, 100 nM
    Incubation Time: 7 days
    Result: Enhanced α-syn PFF-induced p-α-synSer129 expression and co-localized primarily in mitochondria.
    In Vivo

    6PPD-Q (0.1, 1, 10, 100 μg/kg, p.o., once daily for 21 days) induces intestinal injury in ICR mice, characterized by increased inflammatory response in the jejunum and ileum and impaired intestinal barrier integrity[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: 6PPD-Q-induced intestinal injury ICR mouse model[3]
    Dosage: 0.1, 1, 10, 100 μg/kg
    Administration: Oral gavage (p.o.), once daily for 21 days
    Result: Dose-dependently disrupted intestinal barrier integrity, primarily affecting the jejunum and ileum, with no significant impact on the duodenum and colon. At exposure doses ≥10 μg/kg, TNF-α, IL-1, and IL-6 levels significantly increased, indicating intestinal inflammation.
    Molecular Weight

    298.38

    Formula

    C18H22N2O2
    CAS No.
    Appearance

    Solid

    Color

    Pink to red

    SMILES

    O=C1C(NC(C)CC(C)C)=CC(C(NC2=CC=CC=C2)=C1)=O
    Structure Classification
    Initial Source
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 5 mg/mL (16.76 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.3514 mL 16.7572 mL 33.5143 mL
    5 mM 0.6703 mL 3.3514 mL 6.7029 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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    In Vivo:

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  0.5% CMC-Na/saline water

      Solubility: 1.25 mg/mL (4.19 mM); Suspended solution; Need ultrasonic

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    Working solution concentration: mg/mL
    Purity & Documentation

    Purity: 99.77%

    SDS (393 KB)

    COA (246 KB) HNMR (254 KB) LCMS (326 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 3.3514 mL 16.7572 mL 33.5143 mL 83.7858 mL
    5 mM 0.6703 mL 3.3514 mL 6.7029 mL 16.7572 mL
    10 mM 0.3351 mL 1.6757 mL 3.3514 mL 8.3786 mL
    15 mM 0.2234 mL 1.1171 mL 2.2343 mL 5.5857 mL
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    6PPD-Q Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    6PPD-Q2754428-18-56PPD-Quinoneα-synucleinEnvironmental Pollutantsα-SynEnvironmental Contaminantsurineintestinal injuryICR mouseprimary dopaminergic neuronsInhibitorinhibitorinhibit

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