2. Metabolic Enzyme/Protease NF-κB Immunology/Inflammation Apoptosis
  3. Endogenous Metabolite Reactive Oxygen Species (ROS) Ferroptosis
  4. Coenzyme Q10

Coenzyme Q10  (Synonyms: CoQ10; Ubiquinone-10; Ubidecarenone)

Cat. No.: HY-N0111 Purity: 99.75%
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Coenzyme Q10 is an essential cofactor of the electron transport chain and a potent antioxidant agent.

For research use only. We do not sell to patients.

CAS No. : 303-98-0

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Customer Review

Based on 14 publication(s) in Google Scholar

Other Forms of Coenzyme Q10:

Coenzyme Q10 Related Antibodies

Top Publications Citing Use of Products

    Coenzyme Q10 purchased from MedChemExpress. Usage Cited in: ACS Nano. 2025 Sep 30;19(38):33828-33840.  [Abstract]

    CoQ10 (40 μM). Ca2+ fluorescence intensity profiles were analyzed for the following treatment groups after 24 h.

    Coenzyme Q10 purchased from MedChemExpress. Usage Cited in: ACS Nano. 2025 Sep 30;19(38):33828-33840.  [Abstract]

    EFP signals recording from cardiomyocytes of different groups following CoQ10 (20-40 μM) treatment at 0, 24, and 48 h.

    Coenzyme Q10 purchased from MedChemExpress. Usage Cited in: Cancer Lett. 2025 Oct 10:630:217903.  [Abstract]

    CCK8 assay to detect the cell viability of indicated OVCAR-5 treated with coenzyme Q10 (0-200 μM, 72 h).

    Coenzyme Q10 purchased from MedChemExpress. Usage Cited in: Commun Biol. 2023 Nov 25;6(1):1201.  [Abstract]

    CoQ10 (20 μM). ATP level in MES23.5 cells. The endogenous ATP level was detected by luminescent cell viability assay, and the data expressed as a percentage of the Con. n = 4.

    Coenzyme Q10 purchased from MedChemExpress. Usage Cited in: Commun Biol. 2023 Nov 25;6(1):1201.  [Abstract]

    CoQ10 (10-20 μM). Expression levels of H3K9ac and H4K5ac in TA-treated MES23.5 cells were determined by Western blotting.

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    Human Endogenous Metabolite Microbial Metabolite

    • Biological Activity

    • Protocol

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Coenzyme Q10 is an essential cofactor of the electron transport chain and a potent antioxidant agent.

    IC50 & Target

    Human Endogenous Metabolite

     

    Cellular Effect
    Cell Line Type Value Description References
    Fibroblast GI50
    220 μM
    Compound: Coenzyme Q10
    Growth inhibition of human FRDA primary patient fibroblasts after 48 hrs by calcein-AM-based cell viability assay
    Growth inhibition of human FRDA primary patient fibroblasts after 48 hrs by calcein-AM-based cell viability assay
    		[PMID: 22137789]
    In Vitro

    Coenzyme Q10 is an obligatory member of the respiratory chain in the mitochondria of all cells. Therefore, it is an essential ingredient in the formation of adenosine triphosphate (ATP), the source of energy in most cellular processes. Coenzyme Q10 is located in the mitochondria, lysosomes, and Golgi and plasma membranes, and provides an antioxidant action either by direct reaction with free radicals or by regeneration of tocopherol and ascorbate from their oxidised state[1]. Coenzyme Q10 is a popular dietary supplement because of its recognition by the public as an important nutrient in supporting human health. The rationale for the use of Coenzyme Q10 as a therapeutic agent in several cardiovascular and degenerative neurologic and neuromuscular diseases is based upon its fundamental role in mitochondrial function and cellular bioenergetics[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Coenzyme Q10 Related Antibodies
    In Vivo

    Because of its hydrophobicity and large molecular weight, absorption of dietary Coenzyme Q10 is slow and limited. In the case of dietary supplements, solubilized Coenzyme Q10 formulations show enhanced bioavailability. The Tmax is around 6 h, with an elimination half-life of about 33 h. The reference intervals for plasma Coenzyme Q10 range from 0.40 to 1.91 mM in healthy subjects. With Coenzyme Q10 supplements there is reasonable correlation between increase in plasma Coenzyme Q10 and ingested dose up to a certain point. Animal data show that Coenzyme Q10 in large doses is taken up by all tissues including heart and brain mitochondria[2]. In 12-month-old rats administration of coenzyme Q10 results in significant increases in cerebral cortex mitochondrial concentrations of coenzyme Q10. Oral administration of coenzyme Q10 markedly attenuates striatal lesions produced by systemic administration of 3-nitropropionic acid and significantly increases life span in a transgenic mouse model of familial amyotrophic lateral sclerosis[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    Clinical Trial
    Molecular Weight

    863.34

    Formula

    C59H90O4
    CAS No.
    Appearance

    Solid

    Color

    Yellow to orange

    SMILES

    O=C1C(C/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)\C)=C(C)C(C(OC)=C1OC)=O
    Structure Classification
    Initial Source
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    -20°C, sealed storage, away from moisture and light

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

    Solvent & Solubility
    In Vitro: 

    DMF : 20 mg/mL (23.17 mM; ultrasonic and warming and heat to 60°C)

    Ethanol : 2.5 mg/mL (2.90 mM; ultrasonic and warming and heat to 60°C)

    DMSO : < 1 mg/mL (insoluble or slightly soluble)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.1583 mL 5.7915 mL 11.5829 mL
    5 mM 0.2317 mL 1.1583 mL 2.3166 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
    ×
    Volume
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    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

    ×
    Volume (start)

    V1

    =
    Concentration (final)

    C2

    ×
    Volume (final)

    V2

    In Vivo:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMF    90% (20% SBE-β-CD in Saline)

      Solubility: 3 mg/mL (3.47 mM); Suspended solution; Need ultrasonic

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  15% Cremophor EL    85% Saline

      Solubility: 10 mg/mL (11.58 mM); Suspended solution; Need ultrasonic

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    Purity & Documentation

    Purity: 99.75%

    SDS (393 KB)

    COA (238 KB) RP-HPLC (208 KB)

    Handling Instructions (2659 KB)
    References
    Animal Administration
    [3]

    Rats[3]

    The effects of oral administration of coenzyme Q10 on 3-NP-induced striatal lesions are examined in 300- to 350-g rats (n=5-10). Animals receive either rat chow supplemented with coenzyme Q10 at 200 mg/kg or unsupplemented rat chow. After 1 week they are treated with 3-NP at a dose of 10 mgykg i.p. twice a day until either a control or treated animal became symptomatic with hindlimb dystonia, and then sacrificed in pairs[3].

    Mice[3]

    To determine whether coenzyme Q10 exerts neuroprotective effects in a transgenic mouse model of a human neurodegenerative disorder, coenzyme Q10 (200 mg/kg) is administered orally to 16 transgenic mice overexpressing a human CuyZn superoxide dismutase (SOD1) mutation, as compared with 13 animals that receive unsupplemented rat chow. The mice used are the G1 line, which expresses high levels of human SOD with the G93A mutation. Treatment is started at 50 days after birth. Treatment is continued until mice reach end-stage disease[3].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    Ethanol / DMF 1 mM 1.1583 mL 5.7915 mL 11.5829 mL 28.9573 mL
    DMF 5 mM 0.2317 mL 1.1583 mL 2.3166 mL 5.7915 mL
    10 mM 0.1158 mL 0.5791 mL 1.1583 mL 2.8957 mL
    15 mM 0.0772 mL 0.3861 mL 0.7722 mL 1.9305 mL
    20 mM 0.0579 mL 0.2896 mL 0.5791 mL 1.4479 mL
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    Coenzyme Q10 Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Coenzyme Q10303-98-0CoQ10 Ubiquinone-10 UbidecarenoneCoenzyme Q 10Coenzyme Q-10CoQ 10CoQ-10Ubiquinone10Ubiquinone 10Ubiquinone-10Endogenous MetaboliteReactive Oxygen Species (ROS)FerroptosisInhibitorinhibitorinhibit

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