2. Metabolic Enzyme/Protease NF-κB Immunology/Inflammation Apoptosis
  3. Endogenous Metabolite Reactive Oxygen Species Ferroptosis
  4. Coenzyme Q10

Coenzyme Q10  (Synonyms: CoQ10; Ubiquinone-10; Ubidecarenone)

Cat. No.: HY-N0111 Purity: ≥98.0%
COA Handling Instructions

Molarity Calculator

Coenzyme Q10 is an essential cofactor of the electron transport chain and a potent antioxidant agent.

For research use only. We do not sell to patients.

Coenzyme Q10 Chemical Structure

Coenzyme Q10 Chemical Structure

CAS No. : 303-98-0

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Coenzyme Q10:

Coenzyme Q10 Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Coenzyme Q10

  • Biological Activity

  • Protocol

  • Purity & Documentation

  • References

  • Customer Review

Description

Coenzyme Q10 is an essential cofactor of the electron transport chain and a potent antioxidant agent.

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

Coenzyme Q10 is an obligatory member of the respiratory chain in the mitochondria of all cells. Therefore, it is an essential ingredient in the formation of adenosine triphosphate (ATP), the source of energy in most cellular processes. Coenzyme Q10 is located in the mitochondria, lysosomes, and Golgi and plasma membranes, and provides an antioxidant action either by direct reaction with free radicals or by regeneration of tocopherol and ascorbate from their oxidised state[1]. Coenzyme Q10 is a popular dietary supplement because of its recognition by the public as an important nutrient in supporting human health. The rationale for the use of Coenzyme Q10 as a therapeutic agent in several cardiovascular and degenerative neurologic and neuromuscular diseases is based upon its fundamental role in mitochondrial function and cellular bioenergetics[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Coenzyme Q10 Related Antibodies
In Vivo

Because of its hydrophobicity and large molecular weight, absorption of dietary Coenzyme Q10 is slow and limited. In the case of dietary supplements, solubilized Coenzyme Q10 formulations show enhanced bioavailability. The Tmax is around 6 h, with an elimination half-life of about 33 h. The reference intervals for plasma Coenzyme Q10 range from 0.40 to 1.91 mM in healthy subjects. With Coenzyme Q10 supplements there is reasonable correlation between increase in plasma Coenzyme Q10 and ingested dose up to a certain point. Animal data show that Coenzyme Q10 in large doses is taken up by all tissues including heart and brain mitochondria[2]. In 12-month-old rats administration of coenzyme Q10 results in significant increases in cerebral cortex mitochondrial concentrations of coenzyme Q10. Oral administration of coenzyme Q10 markedly attenuates striatal lesions produced by systemic administration of 3-nitropropionic acid and significantly increases life span in a transgenic mouse model of familial amyotrophic lateral sclerosis[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

863.34

Formula

C59H90O4
CAS No.
Appearance

Solid

Color

Yellow to orange

SMILES

O=C1C(C/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)\C)=C(C)C(C(OC)=C1OC)=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture and light

*The compound is unstable in solutions, freshly prepared is recommended.

Solvent & Solubility
In Vitro: 

DMF : 20 mg/mL (23.17 mM; ultrasonic and warming and heat to 60°C)

Ethanol : 2.5 mg/mL (2.90 mM; ultrasonic and warming and heat to 60°C)

H2O : < 0.1 mg/mL (insoluble)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.1583 mL 5.7915 mL 11.5829 mL
5 mM 0.2317 mL 1.1583 mL 2.3166 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  15% Cremophor EL    85% Saline

    Solubility: 10 mg/mL (11.58 mM); Suspended solution; Need ultrasonic

  • Protocol 2

    Add each solvent one by one:  10% DMF    90% (20% SBE-β-CD in Saline)

    Solubility: 3 mg/mL (3.47 mM); Suspended solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥98.0%

COA (238 KB) HNMR (291 KB)

Handling Instructions (2659 KB)
References
Animal Administration
[3]

Rats[3]

The effects of oral administration of coenzyme Q10 on 3-NP-induced striatal lesions are examined in 300- to 350-g rats (n=5-10). Animals receive either rat chow supplemented with coenzyme Q10 at 200 mg/kg or unsupplemented rat chow. After 1 week they are treated with 3-NP at a dose of 10 mgykg i.p. twice a day until either a control or treated animal became symptomatic with hindlimb dystonia, and then sacrificed in pairs[3].

Mice[3]

To determine whether coenzyme Q10 exerts neuroprotective effects in a transgenic mouse model of a human neurodegenerative disorder, coenzyme Q10 (200 mg/kg) is administered orally to 16 transgenic mice overexpressing a human CuyZn superoxide dismutase (SOD1) mutation, as compared with 13 animals that receive unsupplemented rat chow. The mice used are the G1 line, which expresses high levels of human SOD with the G93A mutation. Treatment is started at 50 days after birth. Treatment is continued until mice reach end-stage disease[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
Ethanol / DMF 1 mM 1.1583 mL 5.7915 mL 11.5829 mL 28.9573 mL
DMF 5 mM 0.2317 mL 1.1583 mL 2.3166 mL 5.7915 mL
10 mM 0.1158 mL 0.5791 mL 1.1583 mL 2.8957 mL
15 mM 0.0772 mL 0.3861 mL 0.7722 mL 1.9305 mL
20 mM 0.0579 mL 0.2896 mL 0.5791 mL 1.4479 mL
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Coenzyme Q10 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Coenzyme Q10303-98-0CoQ10 Ubiquinone-10 UbidecarenoneCoenzyme Q 10Coenzyme Q-10CoQ 10CoQ-10Ubiquinone10Ubiquinone 10Ubiquinone-10Endogenous MetaboliteReactive Oxygen SpeciesFerroptosisInhibitorinhibitorinhibit

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