1. Metabolic Enzyme/Protease
  2. Endogenous Metabolite
    Reactive Oxygen Species
  3. Coenzyme Q10

Coenzyme Q10 (Synonyms: CoQ10; Ubiquinone-10)

Cat. No.: HY-N0111 Purity: ≥98.0%
Handling Instructions

Coenzyme Q10 is an essential cofactor of the electron transport chain and a potent antioxidant agent.

For research use only. We do not sell to patients.

Coenzyme Q10 Chemical Structure

Coenzyme Q10 Chemical Structure

CAS No. : 303-98-0

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Coenzyme Q10:

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Coenzyme Q10 is an essential cofactor of the electron transport chain and a potent antioxidant agent.

IC50 & Target

Human Endogenous Metabolite


In Vitro

Coenzyme Q10 is an obligatory member of the respiratory chain in the mitochondria of all cells. Therefore, it is an essential ingredient in the formation of adenosine triphosphate (ATP), the source of energy in most cellular processes. Coenzyme Q10 is located in the mitochondria, lysosomes, and Golgi and plasma membranes, and provides an antioxidant action either by direct reaction with free radicals or by regeneration of tocopherol and ascorbate from their oxidised state[1]. Coenzyme Q10 is a popular dietary supplement because of its recognition by the public as an important nutrient in supporting human health. The rationale for the use of Coenzyme Q10 as a therapeutic agent in several cardiovascular and degenerative neurologic and neuromuscular diseases is based upon its fundamental role in mitochondrial function and cellular bioenergetics[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Because of its hydrophobicity and large molecular weight, absorption of dietary Coenzyme Q10 is slow and limited. In the case of dietary supplements, solubilized Coenzyme Q10 formulations show enhanced bioavailability. The Tmax is around 6 h, with an elimination half-life of about 33 h. The reference intervals for plasma Coenzyme Q10 range from 0.40 to 1.91 mM in healthy subjects. With Coenzyme Q10 supplements there is reasonable correlation between increase in plasma Coenzyme Q10 and ingested dose up to a certain point. Animal data show that Coenzyme Q10 in large doses is taken up by all tissues including heart and brain mitochondria[2]. In 12-month-old rats administration of coenzyme Q10 results in significant increases in cerebral cortex mitochondrial concentrations of coenzyme Q10. Oral administration of coenzyme Q10 markedly attenuates striatal lesions produced by systemic administration of 3-nitropropionic acid and significantly increases life span in a transgenic mouse model of familial amyotrophic lateral sclerosis[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight









Room temperature in continental US; may vary elsewhere.


4°C, protect from light

*The compound is unstable in solutions, freshly prepared is recommended.

Solvent & Solubility
In Vitro: 

DMF : 40 mg/mL (46.33 mM; Need ultrasonic)

Ethanol : 2.5 mg/mL (2.90 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.1583 mL 5.7915 mL 11.5829 mL
5 mM 0.2317 mL 1.1583 mL 2.3166 mL
10 mM 0.1158 mL 0.5791 mL 1.1583 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMF    90% (20% SBE-β-CD in saline)

    Solubility: 3 mg/mL (3.47 mM); Suspended solution; Need ultrasonic

*All of the co-solvents are provided by MCE.
Animal Administration


The effects of oral administration of coenzyme Q10 on 3-NP-induced striatal lesions are examined in 300- to 350-g rats (n=5-10). Animals receive either rat chow supplemented with coenzyme Q10 at 200 mg/kg or unsupplemented rat chow. After 1 week they are treated with 3-NP at a dose of 10 mgykg i.p. twice a day until either a control or treated animal became symptomatic with hindlimb dystonia, and then sacrificed in pairs[3].


To determine whether coenzyme Q10 exerts neuroprotective effects in a transgenic mouse model of a human neurodegenerative disorder, coenzyme Q10 (200 mg/kg) is administered orally to 16 transgenic mice overexpressing a human CuyZn superoxide dismutase (SOD1) mutation, as compared with 13 animals that receive unsupplemented rat chow. The mice used are the G1 line, which expresses high levels of human SOD with the G93A mutation. Treatment is started at 50 days after birth. Treatment is continued until mice reach end-stage disease[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.


Purity: ≥98.0%

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Coenzyme Q10CoQ10 Ubiquinone-10Coenzyme Q 10Coenzyme Q-10CoQ 10CoQ-10Ubiquinone10Ubiquinone 10Ubiquinone-10Endogenous MetaboliteReactive Oxygen SpeciesFerroptosisInhibitorinhibitorinhibit

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