Coenzyme Q10
Based on 15 publication(s) in Google Scholar
Coenzyme Q10 is an essential cofactor of the electron transport chain and a potent antioxidant agent.
For research use only. We do not sell to patients.
- Purity: 99.75%
- CAS No.: 303-98-0
- Formula: C59H90O4
- Molecular Weight:863.34
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Storage:
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocol
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Coenzyme Q10
More- Cell Host Microbe. 2025 Oct 8;33(10):1715-1730.e5. [Abstract]
- ACS Nano. 2025 Sep 30;19(38):33828-33840. [Abstract]
- ACS Nano. 2024 Nov 12;18(45):31569-31585. [Abstract]
- J Nanobiotechnology. 2026 Mar 17;24(1):389.
- Mol Psychiatry. 2025 Sep 16. [Abstract]
- Cancer Lett. 2025 Oct 10:630:217903. [Abstract]
- Br J Pharmacol. 2025 May 13. [Abstract]
- Int J Nanomedicine. 2025 Mar 17:20:3363-3378. [Abstract]
- Commun Biol. 2023 Nov 25;6(1):1201. [Abstract]
- Int J Antimicrob Agents. 2025 Nov 25;67(1):107679. [Abstract]
- Environ Toxicol Pharmacol. 2026 Mar:122:104954. [Abstract]
- J Biochem Mol Toxicol. 2024 Nov;38(11):e70023. [Abstract]
- J Egypt Natl Canc Inst. 2025 Mar 10;37(1):7. [Abstract]
- Res Sq. 2025 Oct 9.
- bioRxiv. 2024 July 31.
Customer Validation & Images
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Bio/Physico-chemical Assay
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Bio/Physico-chemical Assay
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Cell Proliferation/Viability Assay
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Bio/Physico-chemical Assay
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WB
All Endogenous Metabolite Isoforms
More
Biological Activity
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Human Endogenous Metabolite |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Fibroblast | GI50 |
220 μM
Compound: Coenzyme Q10
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Growth inhibition of human FRDA primary patient fibroblasts after 48 hrs by calcein-AM-based cell viability assay
Growth inhibition of human FRDA primary patient fibroblasts after 48 hrs by calcein-AM-based cell viability assay
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[PMID: 22137789] |
Coenzyme Q10 is an obligatory member of the respiratory chain in the mitochondria of all cells. Therefore, it is an essential ingredient in the formation of adenosine triphosphate (ATP), the source of energy in most cellular processes. Coenzyme Q10 is located in the mitochondria, lysosomes, and Golgi and plasma membranes, and provides an antioxidant action either by direct reaction with free radicals or by regeneration of tocopherol and ascorbate from their oxidised state[1]. Coenzyme Q10 is a popular dietary supplement because of its recognition by the public as an important nutrient in supporting human health. The rationale for the use of Coenzyme Q10 as a therapeutic agent in several cardiovascular and degenerative neurologic and neuromuscular diseases is based upon its fundamental role in mitochondrial function and cellular bioenergetics[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 303-98-0
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Appearance Solid
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Molecular Weight 863.34
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Formula C59H90O4
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Color Yellow to orange
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SMILES
O=C1C(C/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)\C)=C(C)C(C(OC)=C1OC)=O
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Synonyms
CoQ10; Ubiquinone-10; Ubidecarenone
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (15)
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Journal Impact Factor
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Most Recent
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Cell Host Microbe
2025 Oct 8;33(10):1715-1730.e5. PMID: 40961933 -
ACS Nano
Exploring Metabolic Abnormalities of Amino Acids in Preeclampsia-Associated Cardiac Physiological Dysfunction via Cardiomyocyte-Based Multimodal Biosensing. [Abstract]2025 Sep 30;19(38):33828-33840. PMID: 40939054
Coenzyme Q10 purchased from MedChemExpress. Usage Cited in: ACS Nano. 2025 Sep 30;19(38):33828-33840. [Abstract]
CoQ10 (40 μM). Ca2+ fluorescence intensity profiles were analyzed for the following treatment groups after 24 h.
Coenzyme Q10 purchased from MedChemExpress. Usage Cited in: ACS Nano. 2025 Sep 30;19(38):33828-33840. [Abstract]
EFP signals recording from cardiomyocytes of different groups following CoQ10 (20-40 μM) treatment at 0, 24, and 48 h.
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ACS Nano
Unveiling the Heart's Hidden Enemy: Dynamic Insights into Polystyrene Nanoplastic-Induced Cardiotoxicity Based on Cardiac Organoid-on-a-Chip. [Abstract]2024 Nov 12;18(45):31569-31585. PMID: 39482939 -
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Mol Psychiatry
Early-life inflammation increases aggressive behavior in adult male mice through an astrocyte-neuron signaling. [Abstract]2025 Sep 16. PMID: 40954280 -
Cancer Lett
Metabolic gatekeeper ACAD9 coordinates linoleic acid metabolism and redox homeostasis via mitochondrial complex I to drive ovarian cancer progression. [Abstract]2025 Oct 10:630:217903. PMID: 40618880
Coenzyme Q10 purchased from MedChemExpress. Usage Cited in: Cancer Lett. 2025 Oct 10:630:217903. [Abstract]
CCK8 assay to detect the cell viability of indicated OVCAR-5 treated with coenzyme Q10 (0-200 μM, 72 h).
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Br J Pharmacol
Contributions of synaptic energetic dysfunction by microtubule dynamics and microtubule-based mitochondrial transport disorder to morphine tolerance. [Abstract]2025 May 13. PMID: 40361281 -
Int J Nanomedicine
Aptamer Functionalized Liposomes Co-Loaded with Exenatide-4 and Coenzyme Q10 Ameliorate Type 2 Diabetes Mellitus by Improving Pancreatic β Cell Function. [Abstract]2025 Mar 17:20:3363-3378. PMID: 40125440 -
Commun Biol
ACO2 deficiency increases vulnerability to Parkinson's disease via dysregulating mitochondrial function and histone acetylation-mediated transcription of autophagy genes. [Abstract]2023 Nov 25;6(1):1201. PMID: 38007539
Coenzyme Q10 purchased from MedChemExpress. Usage Cited in: Commun Biol. 2023 Nov 25;6(1):1201. [Abstract]
CoQ10 (20 μM). ATP level in MES23.5 cells. The endogenous ATP level was detected by luminescent cell viability assay, and the data expressed as a percentage of the Con. n = 4.
Coenzyme Q10 purchased from MedChemExpress. Usage Cited in: Commun Biol. 2023 Nov 25;6(1):1201. [Abstract]
CoQ10 (10-20 μM). Expression levels of H3K9ac and H4K5ac in TA-treated MES23.5 cells were determined by Western blotting.
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Int J Antimicrob Agents
2025 Nov 25;67(1):107679. PMID: 41308844 -
Environ Toxicol Pharmacol
2026 Mar:122:104954. PMID: 41644025 -
J Biochem Mol Toxicol
Protective effect and mechanism of CoQ10 in mitochondrial dysfunction in diquat-induced renal proximal tubular injury. [Abstract]2024 Nov;38(11):e70023. PMID: 39434449 -
J Egypt Natl Canc Inst
Exploring potential additive effects of 5-fluorouracil, thymoquinone, and coenzyme Q10 triple therapy on colon cancer cells in relation to glycolysis and redox status modulation. [Abstract]2025 Mar 10;37(1):7. PMID: 40059278 -
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Solvent & Solubility
DMF : 20 mg/mL (23.17 mM; ultrasonic and warming and heat to 60°C)
Ethanol : 2.5 mg/mL (2.90 mM; ultrasonic and warming and heat to 60°C)
DMSO : < 1 mg/mL (insoluble or slightly soluble)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMF 90% (20% SBE-β-CD in Saline)
Solubility: 3 mg/mL (3.47 mM); Suspended solution; Need ultrasonic
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 15% Cremophor EL 85% Saline
Solubility: 10 mg/mL (11.58 mM); Suspended solution; Need ultrasonic
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
Protocol
Rats[3]
The effects of oral administration of coenzyme Q10 on 3-NP-induced striatal lesions are examined in 300- to 350-g rats (n=5-10). Animals receive either rat chow supplemented with coenzyme Q10 at 200 mg/kg or unsupplemented rat chow. After 1 week they are treated with 3-NP at a dose of 10 mgykg i.p. twice a day until either a control or treated animal became symptomatic with hindlimb dystonia, and then sacrificed in pairs[3].
Mice[3]
To determine whether coenzyme Q10 exerts neuroprotective effects in a transgenic mouse model of a human neurodegenerative disorder, coenzyme Q10 (200 mg/kg) is administered orally to 16 transgenic mice overexpressing a human CuyZn superoxide dismutase (SOD1) mutation, as compared with 13 animals that receive unsupplemented rat chow. The mice used are the G1 line, which expresses high levels of human SOD with the G93A mutation. Treatment is started at 50 days after birth. Treatment is continued until mice reach end-stage disease[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Purity & Documentation
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Data Sheet (273 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Yang YK, et al. Coenzyme Q10 treatment of cardiovascular disorders of ageing including heart failure, hypertension and endothelial dysfunction. Clin Chim Acta. 2015 Oct 23;450:83-9. [Content Brief]
[2]. Bhagavan HN, et al. Coenzyme Q10: absorption, tissue uptake, metabolism and pharmacokinetics. Free Radic Res. 2006 May;40(5):445-53. [Content Brief]
[3]. Matthews RT, et al. Coenzyme Q10 administration increases brain mitochondrial concentrations and exerts neuroprotective effects. Proc Natl Acad Sci U S A. 1998 Jul 21;95(15):8892-7. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| Ethanol / DMF | 1 mM | 1.1583 mL | 5.7915 mL | 11.5829 mL | 28.9573 mL |
| DMF | 5 mM | 0.2317 mL | 1.1583 mL | 2.3166 mL | 5.7915 mL |
| 10 mM | 0.1158 mL | 0.5791 mL | 1.1583 mL | 2.8957 mL | |
| 15 mM | 0.0772 mL | 0.3861 mL | 0.7722 mL | 1.9305 mL | |
| 20 mM | 0.0579 mL | 0.2896 mL | 0.5791 mL | 1.4479 mL |
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