Geldanamycin

Name: Geldanamycin
Brand: MedChemExpress
SKU: HY-15230
Rating: 5.0 (24 reviews)

Cat. No.: HY-15230 Purity: 99.78%: FAQs
Data Sheet SDS COA Handling Instructions

Geldanamycin is a Hsp90 inhibitor with antimicrobial activity against many Gram-positive and some Gram-negative bacteria. Geldanamycin has anti-influenza virus H5N1 activities.

For research use only. We do not sell to patients.

Geldanamycin Chemical Structure

CAS No. : 30562-34-6

Size	Price	Stock	Quantity
Solid + Solvent
10 mM * 1 mL in DMSO ready for reconstitution	USD 55	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 55	In-stock	Estimated Time of Arrival: December 31
Solid
10 mg	USD 50	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 90	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 150	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 250	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 24 publication(s) in Google Scholar

21 Publications Citing Use of MCE Geldanamycin

: Geldanamycin purchased from MedChemExpress. Usage Cited in: J Cell Biochem. 2019 Sep;120(9):16254-16263. [Abstract]; Caspase 3, caspase 9, cleaved caspase 3, cleaved caspase 9, and β-actin protein expression analyzed by Western blot with the treatment of Geldanamycin.

: Geldanamycin purchased from MedChemExpress. Usage Cited in: J Cell Biochem. 2019 Sep;120(9):16254-16263. [Abstract]; Bcl2, Bax, and β-actin protein expression is analyzed by Western blot with the treatment of Geldanamycin.

: Geldanamycin purchased from MedChemExpress. Usage Cited in: J Cell Biochem. 2018 Oct 10. [Abstract]; Geldanamycin (GA) attenuatea TNF-α-mediated activation of MAPK and NF-κB signaling pathways.

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Geldanamycin is a Hsp90 inhibitor with antimicrobial activity against many Gram-positive and some Gram-negative bacteria. Geldanamycin has anti-influenza virus H5N1 activities.

IC₅₀ & Target^[4]

HSP90

1.2 μM (Kd)

In Vitro

Geldanamycin significantly delays and reduces viperin expression, indicating that IRF3 is involved in viperin induction in RAW264.7 cells^[1].
Geldanamycin, a benzoquinone ansamycin, protected against neuronal injury induced by oxygen-glucose deprivation (OGD)/zVAD treatment in cultured primary neurons. More importantly, Geldanamycin decreases RIP1 protein level in a time and concentration-dependent manner. Geldanamycin also decreases the Hsp90 protein level, which causes instability of RIP1 protein, resulting in decreased RIP1 protein level but not RIP1 mRNA level after Geldanamycin treatment^[2].
Geldanamycin is identified as the first natural product inhibitor of Hsp90 that binds to the N-terminal ATPase domain of Hsp90 to inhibit its chaperone function, and significantly induces tumor cell death via an apoptotic mechanism^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

560.64

Appearance

Solid

Formula

C₂₉H₄₀N₂O₉

CAS No.

30562-34-6

SMILES

COC(C(C=C1NC(/C(C)=C/C=C/[C@H](OC)[C@@H](OC(N)=O)/C(C)=C/[C@H](C)[C@H]2O)=O)=O)=C(C[C@H](C[C@@H]2OC)C)C1=O

Structure Classification

Initial Source

Streptomyces hygroscopicus

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (89.18 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.7837 mL	8.9184 mL	17.8368 mL
5 mM	0.3567 mL	1.7837 mL	3.5674 mL
10 mM	0.1784 mL	0.8918 mL	1.7837 mL

*Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: 2.5 mg/mL (4.46 mM); Suspended solution; Need ultrasonic
2.

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: 2.5 mg/mL (4.46 mM); Suspended solution; Need ultrasonic

*All of the co-solvents are available by MedChemExpress (MCE).

Purity & Documentation

Purity: 99.78%

Select Batch:

Data Sheet (284 KB) SDS (393 KB)

COA (262 KB) HNMR (204 KB) LCMS (446 KB)

Handling Instructions (2659 KB)

References

[1]. Tang HB, et al. Viperin inhibits rabies virus replication via reduced cholesterol and sphingomyelin and is regulated upstream by TLR4. Sci Rep. 2016 Jul 26;6:30529 [Content Brief]

[2]. Chen WW, et al. RIP1 mediates the protection of Geldanamycin on neuronal injury induced by oxygen-glucosedeprivation combined with zVAD in primary cortical neurons. J Neurochem. 2012 Jan;120(1):70-7. [Content Brief]

[3]. Lin Z, et al. 17-ABAG, a novel Geldanamycin derivative, inhibits LNCaP-cell proliferation through heat shock protein 90 inhibition. Int J Mol Med. 2015 Aug;36(2):424-32. [Content Brief]

[4]. Roe SM, et al. Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin. J Med Chem. 1999 Jan 28;42(2):260-6. [Content Brief]

[5]. Wang C, et al. Geldanamycin Reduces Acute Respiratory Distress Syndrome and Promotes the Survival of Mice Infected with the Highly Virulent H5N1 Influenza Virus. Front Cell Infect Microbiol. 2017 Jun 15;7:267. [Content Brief]

Geldanamycin Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Keywords:

Geldanamycin30562-34-6HSPBacterialInfluenza VirusAntibioticHeat shock proteinsInhibitorinhibitorinhibit

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Geldanamycin

Customer Review

Geldanamycin Related Antibodies

21 Publications Citing Use of MCE Geldanamycin

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Biological Activity

Purity & Documentation

References

Customer Review

Geldanamycin Related Antibodies

Geldanamycin Related Classifications

Molarity Calculator

Dilution Calculator

The molarity calculator equation

The dilution calculator equation

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