1. Cell Cycle/DNA Damage
    Metabolic Enzyme/Protease
  2. HSP

Geldanamycin 

Cat. No.: HY-15230 Purity: 99.78%
Handling Instructions

Geldanamycin is a specific inhibitor of interferon regulatory factor 3 (IRF3) (by inhibiting Hsp90 of the IRF3 phosphorylation chaperone, with a Kd of 1.2 μM.).

For research use only. We do not sell to patients.

Geldanamycin Chemical Structure

Geldanamycin Chemical Structure

CAS No. : 30562-34-6

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 131 In-stock
Estimated Time of Arrival: December 31
5 mg USD 106 In-stock
Estimated Time of Arrival: December 31
10 mg USD 161 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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  • Biological Activity

  • Technical Information

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  • References

Description

Geldanamycin is a specific inhibitor of interferon regulatory factor 3 (IRF3) (by inhibiting Hsp90 of the IRF3 phosphorylation chaperone, with a Kd of 1.2 μM.).

IC50 & Target[4]

HSP90

1.2 μM (Kd)

In Vitro

Geldanamycin significantly delays and reduces viperin expression, indicating that IRF3 is involved in viperin induction in RAW264.7 cells[1]. Geldanamycin (GA), a benzoquinone ansamycin, protected against neuronal injury induced by oxygen-glucose deprivation (OGD)/zVAD treatment in cultured primary neurons. More importantly, Geldanamycin decreases RIP1 protein level in a time and concentration-dependent manner. Geldanamycin also decreases the Hsp90 protein level, which causes instability of RIP1 protein, resulting in decreased RIP1 protein level but not RIP1 mRNA level after Geldanamycin treatment[2]. Geldanamycin (GA) is identified as the first natural product inhibitor of Hsp90 that binds to the N-terminal ATPase domain of Hsp90 to inhibit its chaperone function, and significantly induces tumor cell death via an apoptotic mechanism[3].

Solvent & Solubility
In Vitro: 

DMSO : ≥ 24 mg/mL (42.81 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7837 mL 8.9184 mL 17.8368 mL
5 mM 0.3567 mL 1.7837 mL 3.5674 mL
10 mM 0.1784 mL 0.8918 mL 1.7837 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

560.64

Formula

C₂₉H₄₀N₂O₉

CAS No.

30562-34-6

SMILES

COC(C(C=C1NC(/C(C)=C/C=C/[[email protected]](OC)[[email protected]@H](OC(N)=O)/C(C)=C/[[email protected]](C)[[email protected]]2O)=O)=O)=C(C[[email protected]](C[[email protected]@H]2OC)C)C1=O

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Purity: 99.78%

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Product Name:
Geldanamycin
Cat. No.:
HY-15230
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Geldanamycin

Cat. No.: HY-15230