1. Cell Cycle/DNA Damage
    Metabolic Enzyme/Protease
  2. HSP

Geldanamycin 

Cat. No.: HY-15230 Purity: 99.78%
Handling Instructions

Geldanamycin is a Hsp90 inhibitor with antimicrobial activity against many Gram-positive and some Gram-negative bacteria.

For research use only. We do not sell to patients.

Geldanamycin Chemical Structure

Geldanamycin Chemical Structure

CAS No. : 30562-34-6

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 131 In-stock
Estimated Time of Arrival: December 31
5 mg USD 106 In-stock
Estimated Time of Arrival: December 31
10 mg USD 161 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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    Geldanamycin purchased from MCE. Usage Cited in: J Cell Biochem. 2018 Oct 10.

    Geldanamycin (GA) attenuatea TNF-α-mediated activation of MAPK and NF-κB signaling pathways.

    View All HSP Isoform Specific Products:

    • Biological Activity

    • Technical Information

    • Purity & Documentation

    • References

    Description

    Geldanamycin is a Hsp90 inhibitor with antimicrobial activity against many Gram-positive and some Gram-negative bacteria.

    IC50 & Target

    Kd: 1.2 μM (Hsp90)[4]

    In Vitro

    Geldanamycin significantly delays and reduces viperin expression, indicating that IRF3 is involved in viperin induction in RAW264.7 cells[1]. Geldanamycin (GA), a benzoquinone ansamycin, protected against neuronal injury induced by oxygen-glucose deprivation (OGD)/zVAD treatment in cultured primary neurons. More importantly, Geldanamycin decreases RIP1 protein level in a time and concentration-dependent manner. Geldanamycin also decreases the Hsp90 protein level, which causes instability of RIP1 protein, resulting in decreased RIP1 protein level but not RIP1 mRNA level after Geldanamycin treatment[2]. Geldanamycin (GA) is identified as the first natural product inhibitor of Hsp90 that binds to the N-terminal ATPase domain of Hsp90 to inhibit its chaperone function, and significantly induces tumor cell death via an apoptotic mechanism[3].

    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 24 mg/mL (42.81 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.7837 mL 8.9184 mL 17.8368 mL
    5 mM 0.3567 mL 1.7837 mL 3.5674 mL
    10 mM 0.1784 mL 0.8918 mL 1.7837 mL
    *Please refer to the solubility information to select the appropriate solvent.
    References
    Molecular Weight

    560.64

    Formula

    C₂₉H₄₀N₂O₉

    CAS No.

    30562-34-6

    SMILES

    COC(C(C=C1NC(/C(C)=C/C=C/[[email protected]](OC)[[email protected]@H](OC(N)=O)/C(C)=C/[[email protected]](C)[[email protected]]2O)=O)=O)=C(C[[email protected]](C[[email protected]@H]2OC)C)C1=O

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Shipping

    Room temperature in continental US; may vary elsewhere

    Purity: 99.78%

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    This equation is commonly abbreviated as: C1V1 = C2V2

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    Product Name:
    Geldanamycin
    Cat. No.:
    HY-15230
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    Geldanamycin

    Cat. No.: HY-15230