1. Metabolic Enzyme/Protease
  2. Endogenous Metabolite
  3. Menadione

Menadione  (Synonyms: Vitamin K3)

Cat. No.: HY-B0332 Purity: 99.53%
COA Handling Instructions

Menadione is a naphthoquinone that is converted into active vitamin K2 in the body. Menadione is a potential anticancer agent and radiosensitizer.

For research use only. We do not sell to patients.

Menadione Chemical Structure

Menadione Chemical Structure

CAS No. : 58-27-5

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Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
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Solid
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1 g USD 119 In-stock
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Customer Review

Based on 14 publication(s) in Google Scholar

Other Forms of Menadione:

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  • Biological Activity

  • Purity & Documentation

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Description

Menadione is a naphthoquinone that is converted into active vitamin K2 in the body. Menadione is a potential anticancer agent and radiosensitizer[1].

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

Menadione (0-100 μM, 24-72 h) induces necrosis at high concentrations (100 μM) and apoptosis at low concentrations (10-20 μM) in AR4-2J cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[2]

Cell Line: AR4-2J cells
Concentration: 0-100 μM
Incubation Time: 24-72 h
Result: Inhibited cell proliferation in time- and dose-dependently manner at lower concentrations (1-20 μM).

Western Blot Analysis[2]

Cell Line: AR4-2J cells
Concentration: 0-100 μM
Incubation Time: 24 h
Result: Induced wild-type P53 at the dose of 1-20 μM.
Induced a low level of wild-type P53 at the dose of 100 μM.
In Vivo

Menadione (25-150 mg/kg, i.v., once time or every other day for five times) produces more severe lesionsin male Wister rats with a single injection than five injections [1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wister rats[1]
Dosage: 25-150 mg/kg
Administration: i.v., once time or every other day for five times
Result: Showed microgranular degeneration of renal tubular cells at the dose of 25 mg/kg.
Observed microgranular degeneration of renal tubular cells and mild pulmonary hemorrhage at the dose of 50 mg/kg.
Produced lesions in the kidney, heart, liver and lung at the dose of 100-150 mg/kg.
Showed kidney apoptosis at the dose of 100-150 mg/kg.
Clinical Trial
Molecular Weight

172.18

Formula

C11H8O2

CAS No.
Appearance

Solid

Color

Light yellow to green yellow

SMILES

O=C1C(C)=CC(C2=C1C=CC=C2)=O

Structure Classification
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 1 years; -20°C, 6 months (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (725.98 mM; Need ultrasonic)

Ethanol : 9.09 mg/mL (52.79 mM; Need ultrasonic)

H2O : 0.1 mg/mL (0.58 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.8079 mL 29.0394 mL 58.0788 mL
5 mM 1.1616 mL 5.8079 mL 11.6158 mL
10 mM 0.5808 mL 2.9039 mL 5.8079 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.08 mg/mL (12.08 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.08 mg/mL (12.08 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.08 mg/mL (12.08 mM); Clear solution

*All of the co-solvents are available by MedChemExpress (MCE).
Purity & Documentation

Purity: 99.53%

References
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Menadione Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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