1. Metabolic Enzyme/Protease
  2. Endogenous Metabolite
  3. Menadione

Menadione (Synonyms: Vitamin K3)

Cat. No.: HY-B0332 Purity: 98.57%
Handling Instructions

Menadione, a synthetic naphthoquinone, can be converted to active vitamin K2 in vivo.

For research use only. We do not sell to patients.

Menadione Chemical Structure

Menadione Chemical Structure

CAS No. : 58-27-5

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 79 In-stock
Estimated Time of Arrival: December 31
500 mg USD 72 In-stock
Estimated Time of Arrival: December 31
1 g USD 108 In-stock
Estimated Time of Arrival: December 31
5 g   Get quote  
10 g   Get quote  

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Description

Menadione, a synthetic naphthoquinone, can be converted to active vitamin K2 in vivo. Target: Others Menadione (Vitamin K3) is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. Menadione is used as a phosphatase inhibitor and an inhibitor of mitochondrial DNA polymerase γ (pol γ). Menadione can be used as an oxidative injury (free radical generator) inducing agent [1].

IC50 & Target

Human Endogenous Metabolite

 

Clinical Trial
Molecular Weight

172.18

Formula

C₁₁H₈O₂

CAS No.

58-27-5

SMILES

O=C1C(C)=CC(C2=C1C=CC=C2)=O

Shipping

Room temperature in continental US; may vary elsewhere

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (290.39 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.8079 mL 29.0394 mL 58.0788 mL
5 mM 1.1616 mL 5.8079 mL 11.6158 mL
10 mM 0.5808 mL 2.9039 mL 5.8079 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (14.52 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (14.52 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Menadione
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HY-B0332
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