Doxorubicin hydrochloride (Standard)
Based on 5 publication(s) in Google Scholar
Doxorubicin hydrochloride (Standard) is the analytical standard of Doxorubicin hydrochloride. This product is intended for research and analytical applications. Doxorubicin (Hydroxydaunorubicin) hydrochloride, a cytotoxic anthracycline antibiotic, is an anti-cancer chemotherapy agent. Doxorubicin hydrochloride is a potent human DNA topoisomerase I and topoisomerase II inhibitor with IC50s of 0.8 μM and 2.67 μM, respectively. Doxorubicin hydrochloride reduces basal phosphorylation of AMPK and its downstream target acetyl-CoA carboxylase. Doxorubicin hydrochloride induces apoptosis and autophagy.
For research use only. We do not sell to patients.
- Purity: 99.33%
- CAS No.: 25316-40-9
- Formula: C27H30ClNO11
- Molecular Weight:579.98
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Product Information
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Chemical Information
- Purity & Documentation
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Doxorubicin hydrochloride (Standard)
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Product Information
The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Chemical Information
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CAS No. 25316-40-9
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Appearance Solid
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Molecular Weight 579.98
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Formula C27H30ClNO11
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Color Orange to red
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SMILES
COC1=C2C(C(C3=C(C2=O)C(O)=C4C(C[C@](O)(C[C@@H]4O[C@]5(C[C@@H]([C@@H]([C@@H](O5)C)O)N)[H])C(CO)=O)=C3O)=O)=CC=C1.[H]Cl
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Synonyms
Hydroxydaunorubicin hydrochloride (Standard); ADR (Standard)
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (5)
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Journal Impact Factor
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Most Recent
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Signal Transduct Target Ther
Cardiomyocyte-specific knockout of ADAM17 alleviates doxorubicin-induced cardiomyopathy via inhibiting TNFα-TRAF3-TAK1-MAPK axis. [Abstract]2024 Oct 16;9(1):273. PMID: 39406701 -
Research (Wash D C)
Dual Regulation of Sprouty 4 Palmitoylation by ZDHHC7 and Palmitoyl-Protein Thioesterase 1: A Potential Therapeutic Strategy for Cisplatin-Resistant Osteosarcoma. [Abstract]2025 May 23:8:0708. PMID: 40416361 -
Acta Pharmacol Sin
Discovery and characterization of a novel HIF-2α agonist for the treatment of CKD-related renal anemia. [Abstract]2025 Oct 1. PMID: 41034402 -
J Neurochem
Young Regulatory T Cell-Derived Extracellular Vesicles Improve Mitochondrial Function and Angiogenesis and Suppress Inflammation in Senescent Brain and Heart. [Abstract]2026 Mar;170(3):e70402. PMID: 41797211 -
Purity & Documentation
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SDS (557 KB)
- English - EN (557 KB)
- Français - FR (557 KB)
- Deutsch - DE (557 KB)
- Norwegian - NO (557 KB)
- Español - ES (557 KB)
- Swedish - SV (557 KB)
- Italian - IT (557 KB)
- Korean - KR (557 KB)
- Portuguese - PT (557 KB)
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Handling Instructions (2659 KB)
References
[1]. John L. Nitiss, et al. Targeting DNA topoisomerase II in cancer chemotherapy.Nat Rev Cancer. 2009 May;9(5):338-50. [Content Brief]
[2]. Hee-KyungRhee,et al. Synthesis, cytotoxicity, and DNA topoisomerase II inhibitory activity of benzofuroquinolinediones. Bioorg Med Chem. 2007 Feb 15;15(4):1651-8. [Content Brief]
[3]. P D Foglesong, et al. Doxorubicin inhibits human DNA topoisomerase I. Cancer Chemother Pharmacol. 1992;30(2):123-5. [Content Brief]
[4]. Nesstor Pilco-Ferreto, et al. Influence of doxorubicin on apoptosis and oxidative stress in breast cancer cell lines. Int J Oncol. 2016 Aug;49(2):753-62. [Content Brief]
[5]. Regine Lüpertz, et al. Dose- and time-dependent effects of doxorubicin on cytotoxicity, cell cycle and apoptotic cell death in human colon cancer cells. Toxicology. 2010 May 27;271(3):115-21. [Content Brief]
[6]. Penelope D Ottewell, et al. Antitumor effects of doxorubicin followed by zoledronic acid in a mouse model of breast cancer. J Natl Cancer Inst. 2008 Aug 20;100(16):1167-78. [Content Brief]
[7]. Koda LY, Van der Kooy D. Doxorubicin: a fluorescent neurotoxin retrogradely transported in the central nervous system. Neurosci Lett. 1983 Mar 28;36(1):1-8. doi: 10.1016/0304-3940(83)90476-7. PMID: 6190113. 9 [Content Brief]
[8]. Kauffman MK, Kauffman ME, Zhu H, Jia Z, Li YR. Fluorescence-Based Assays for Measuring Doxorubicin in Biological Systems. React Oxyg Species (Apex). 2016;2(6):432-439. doi: 10.20455/ros.2016.873. PMID: 29707647; PMCID: PMC5921830. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Doxorubicin hydrochloride (Standard) Related Classifications
HY-15142R Related Classifications
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- Doxorubicin hydrochloride (Standard)
- 25316-40-9
- Hydroxydaunorubicin hydrochloride (Standard)
- ADR (Standard)
- Reference Standards
- Topoisomerase
- ADC Payloads
- AMPK
- Autophagy
- Apoptosis
- HIV
- HBV
- Mitophagy
- Antibiotic
- Bacterial
- Fluorescent Dye
- Cardiotoxicity
- Neurotoxicity
- fluorescence
- Hela
- CRL-6475
- fluorescence detection
- antibiotics
- tumor
- apoptosis
- autophagy
- Inhibitor
- inhibitor
- inhibit