1. NF-κB
  2. Keap1-Nrf2
  3. Danshensu

Danshensu (Synonyms: Dan shen suan A; Salvianic acid A)

Cat. No.: HY-N1913 Purity: >98.0%
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Danshensu, an active ingredient of Salvia miltiorrhiza, shows wide cardiovascular benefit by activating Nrf2 signaling pathway.

For research use only. We do not sell to patients.

Danshensu Chemical Structure

Danshensu Chemical Structure

CAS No. : 76822-21-4

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10 mM * 1  mL in Water USD 66 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

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Danshensu, an active ingredient of Salvia miltiorrhiza, shows wide cardiovascular benefit by activating Nrf2 signaling pathway.

In Vitro

Danshensu (DSS) significantly decreases the level of the marker enzymes (creatine kinase and lactate dehydrogenase) from the coronary effluents and myocardial infarction size. This could markedly contribute to the recovery of cardiac function after I/R injury. DSS also has ROS scavenging activity and boosts endogenous antioxidants such as SOD, CAT, MDA, GSH-PX and HO-1 activities by activating nuclear factor erythroid-2-related factor 2 (Nrf2) signaling pathway which is mediated by Akt and ERK1/2 in western blot analysis[2]

In Vivo

Acute treatment with a single dose of danshensu in rats with normal tHcy does not change plasma tHcy. In contrast, danshensu significantly lowers tHcy in rats with elevated tHcy. The relatively higher cysteine and glutathione levels after treatment with danshensu indicates that its tHcy-lowering effect is via increased activity of the trans-sulphuration pathway[1].

Molecular Weight







OC1=C(O)C=CC(C[[email protected]@H](O)C(O)=O)=C1


Room temperature in continental US; may vary elsewhere.

Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 5 mg/mL (25.23 mM; Need ultrasonic)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.0462 mL 25.2309 mL 50.4617 mL
5 mM 1.0092 mL 5.0462 mL 10.0923 mL
10 mM 0.5046 mL 2.5231 mL 5.0462 mL
*Please refer to the solubility information to select the appropriate solvent.
Animal Administration

All chemicals are dissolved in saline, except for tolcapone which is dissolved in saline containing 20% (v/v) PEG 200. During experiments, rats are fasted overnight and randomLy assigned into different groups. About 200 µL blood is taken from orbital sinus alternatively after ethyl ether anaesthesia, and then the eye is quickly sterilized with alcohol and pressed with cotton. Blood samples are immediately collected into a polypropylene tube containing heparin-Na and centrifuged at 5000 g at 5°C for 3 min. Prepared plasma samples are kept at −20°C and analysed within 48 h.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

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DanshensuDan shen suan ASalvianic acid AKeap1-Nrf2AutophagyApoptosisInhibitorinhibitorinhibit

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