2. NF-κB Autophagy Apoptosis
  3. Keap1-Nrf2 Autophagy Apoptosis
  4. Danshensu

Danshensu  (Synonyms: Dan shen suan A; Salvianic acid A)

Cat. No.: HY-N1913 Purity: ≥98.0%
COA Handling Instructions

Danshensu, an active ingredient of Salvia miltiorrhiza, shows wide cardiovascular benefit by activating Nrf2 signaling pathway.

For research use only. We do not sell to patients.

Danshensu Chemical Structure

Danshensu Chemical Structure

CAS No. : 76822-21-4

Size Price Stock Quantity
Solution
10 mM * 1 mL in Water USD 45 In-stock
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 45 In-stock
Solid
5 mg USD 41 In-stock
10 mg USD 66 In-stock
50 mg USD 132 In-stock
100 mg USD 198 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Danshensu:

Danshensu Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Danshensu

  • Biological Activity

  • Protocol

  • Purity & Documentation

  • References

  • Customer Review

Description

Danshensu, an active ingredient of Salvia miltiorrhiza, shows wide cardiovascular benefit by activating Nrf2 signaling pathway.

In Vitro

Danshensu (DSS) significantly decreases the level of the marker enzymes (creatine kinase and lactate dehydrogenase) from the coronary effluents and myocardial infarction size. This could markedly contribute to the recovery of cardiac function after I/R injury. DSS also has ROS scavenging activity and boosts endogenous antioxidants such as SOD, CAT, MDA, GSH-PX and HO-1 activities by activating nuclear factor erythroid-2-related factor 2 (Nrf2) signaling pathway which is mediated by Akt and ERK1/2 in western blot analysis[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Danshensu Related Antibodies
In Vivo

Acute treatment with a single dose of danshensu in rats with normal tHcy does not change plasma tHcy. In contrast, danshensu significantly lowers tHcy in rats with elevated tHcy. The relatively higher cysteine and glutathione levels after treatment with danshensu indicates that its tHcy-lowering effect is via increased activity of the trans-sulphuration pathway[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

198.17

Appearance

Solid

Formula

C9H10O5
CAS No.
SMILES

OC1=C(O)C=CC(C[C@@H](O)C(O)=O)=C1
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 5 mg/mL (25.23 mM; Need ultrasonic)

DMSO : 1 mg/mL (5.05 mM; ultrasonic and warming and heat to 80°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.0462 mL 25.2309 mL 50.4617 mL
5 mM 1.0092 mL 5.0462 mL 10.0923 mL
10 mM 0.5046 mL 2.5231 mL 5.0462 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  PBS

    Solubility: 10 mg/mL (50.46 mM); Clear solution; Need ultrasonic and heat to 60°C

*All of the co-solvents are available by MCE.
Purity & Documentation
References
Animal Administration
[1]

All chemicals are dissolved in saline, except for tolcapone which is dissolved in saline containing 20% (v/v) PEG 200. During experiments, rats are fasted overnight and randomLy assigned into different groups. About 200 µL blood is taken from orbital sinus alternatively after ethyl ether anaesthesia, and then the eye is quickly sterilized with alcohol and pressed with cotton. Blood samples are immediately collected into a polypropylene tube containing heparin-Na and centrifuged at 5000 g at 5°C for 3 min. Prepared plasma samples are kept at −20°C and analysed within 48 h.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
References
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Danshensu Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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  • Dilution Calculator

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Danshensu76822-21-4Dan shen suan A Salvianic acid AKeap1-Nrf2AutophagyApoptosisInhibitorinhibitorinhibit

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