1. Autophagy
  2. Autophagy
  3. Salvianolic acid B

Salvianolic acid B (Synonyms: Lithospermic acid B)

Cat. No.: HY-N1362 Purity: 99.93%
Handling Instructions

Salvianolic acid B is an active ingredient of Salvia miltiorrhiza, which has been widely applied in China for the management of various microcirculation-related disorders, such as cardiovascular disease, cerebrovascular disease, and diabetic vascular complication.

For research use only. We do not sell to patients.

Salvianolic acid B Chemical Structure

Salvianolic acid B Chemical Structure

CAS No. : 121521-90-2

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
5 mg USD 70 In-stock
Estimated Time of Arrival: December 31
10 mg USD 110 In-stock
Estimated Time of Arrival: December 31
25 mg USD 240 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 4 publication(s) in Google Scholar

Other Forms of Salvianolic acid B:

Top Publications Citing Use of Products

    Salvianolic acid B purchased from MCE. Usage Cited in: Oxid Med Cell Longev. 2020 Jul.

    Expression of Keap1, nuclear and cytosolic Nrf2, HO-1, and NQO1 in the myocardium 3 hours following CA/CPR with or without Sal B treatment. Sal B treatment reduces ROS production via the activation of Nrf2 signaling pathway.
    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Salvianolic acid B is an active ingredient of Salvia miltiorrhiza, which has been widely applied in China for the management of various microcirculation-related disorders, such as cardiovascular disease, cerebrovascular disease, and diabetic vascular complication. IC50 value: Target: In vitro: Salvianolic acid B (SA-B) 1 and 10 micromol/L decrease the cell active TGF-beta1 secretion by 63.3 % and 15.6 % of the control, down-regulat pro-collgen alpha1(I) mRNA expression to 77.0% and 51.8% respectively (P<0.05). SA-B 1 and 10 micromol/L also inhibit MAPK activity by 1 to 2 fold respectively [3]. In vivo: Salvianolic acid B (SalB) (5 mg · kg-1 · h-1) significantly attenuates LPS-induced pulmonary microcirculatory disturbance, including the increase in leukocyte adhesion and albumin leakage. In addition, LPS increases pulmonary tissue wet-to-dry weight ratio and tumor necrosis factor [alpha] and interleukin 8 levels in plasma and bronchoalveolar lavage fluid enhances the expression of E-selectin, intercellular adhesion molecule 1, myeloperoxidase, MMP-2, and MMP-9, whereas it decreases the expression of AQP-1 and AQP-5 in pulmonary tissue, all of which are attenuated by SalB pretreatment[1]. SalB administration (10 mg/kg) significantly ameliorate the Aβ25-35 peptide-induced memory impairment in the passive avoidance task (P<0.05). SalB treatment also reduced the number of activated microglia and astrocytes that are observed during the inflammatory reaction after the administration of the Aβ25-35 peptide. Moreover, SalB markedly reduce inducible nitric oxide synthase and cyclooxygenase-2 expression levels and thiobarbituric acid reactive substances, which are increased by the administration of the Aβ25-35 peptide. Furthermore, SalB administration significantly rescue the Aβ25-35 peptide-induced decrease of choline acetyltransferase and brain-derived neurotrophic factor protein levels[2].

    Molecular Weight

    718.61

    Formula

    C₃₆H₃₀O₁₆

    CAS No.

    121521-90-2

    SMILES

    O=C([[email protected]@H]1[[email protected]@H](C2=CC=C(O)C(O)=C2)OC3=C(O)C=CC(/C=C/C(O[[email protected]@H](C(O)=O)CC4=CC=C(O)C(O)=C4)=O)=C13)O[[email protected]@H](C(O)=O)CC5=CC=C(O)C(O)=C5

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
    4°C 2 years

    *The compound is unstable in solutions, freshly prepared is recommended.

    Solvent & Solubility
    In Vitro: 

    H2O : 50 mg/mL (69.58 mM; ultrasonic and adjust pH to 3 with HCl)

    H2O : ≥ 45 mg/mL (62.62 mM)

    DMSO : 25 mg/mL (34.79 mM; Need ultrasonic)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.3916 mL 6.9579 mL 13.9158 mL
    5 mM 0.2783 mL 1.3916 mL 2.7832 mL
    10 mM 0.1392 mL 0.6958 mL 1.3916 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.08 mg/mL (2.89 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.08 mg/mL (2.89 mM); Clear solution

    • 3.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.08 mg/mL (2.89 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    References

    Purity: 99.93%

    • No file chosen (Maximum size is: 1024 Kb)
    • If you have published this work, please enter the PubMed ID.
    • Your name will appear on the site.
    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass   Concentration   Volume   Molecular Weight *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
    × = ×
    C1   V1   C2   V2

    Keywords:

    Salvianolic acid BLithospermic acid BAutophagyInhibitorinhibitorinhibit

    Your Recently Viewed Products:

    Inquiry Online

    Your information is safe with us. * Required Fields.

    Product Name

     

    Salutation

    Applicant Name *

     

    Email address *

    Phone number *

     

    Organization name *

    Department *

     

    Requested quantity *

    Country or Region *

         

    Remarks

    Bulk Inquiry

    Inquiry Information

    Product Name:
    Salvianolic acid B
    Cat. No.:
    HY-N1362
    Quantity:
    MCE Japan Authorized Agent: