Salvianolic acid B
Based on 21 publication(s) in Google Scholar
Salvianolic acid B is an active ingredient of Salvia miltiorrhiza, which has been widely applied in China for the management of various microcirculation-related disorders, such as cardiovascular disease, cerebrovascular disease, and diabetic vascular complication.
For research use only. We do not sell to patients.
- Purity: 99.90%
- CAS No.: 121521-90-2
- Formula: C36H30O16
- Molecular Weight:718.61
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Storage:Powder -20°C, 3 years , 4°C, 2 years
* The compound is unstable in solutions, freshly prepared is recommended.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Salvianolic acid B
More- Adv Sci (Weinh). 2025 Dec;12(46):e05291. [Abstract]
- Cell Rep Med. 2025 Jul 15;6(7):102208. [Abstract]
- J Neuroinflammation. 2025 Feb 24;22(1):48. [Abstract]
- Phytomedicine. 2026 Jan:150:157736. [Abstract]
- Phytomedicine. 2025 May:140:156484. [Abstract]
- Phytomedicine. 2019 May:58:152754. [Abstract]
- Plant Physiol. 2024 Jul 31;195(4):2843-2859. [Abstract]
- Br J Pharmacol. 2025 Feb;182(4):988-1004. [Abstract]
- Biomater Adv. 2023 Sep:152:213516. [Abstract]
- Pharmaceuticals (Basel). 2022 Jan 31;15(2):179. [Abstract]
- Exp Neurol. 2025 Sep:391:115305. [Abstract]
- FASEB J. 2026 May 31;40(10):e71826. [Abstract]
- Biochim Biophys Acta Mol Cell Res. 2025 Aug 7;1872(8):120041. [Abstract]
- Arch Biochem Biophys. 2025 Feb:764:110233. [Abstract]
- Biochem Biophys Res Commun. 2020 Jun 4;526(3):733-737. [Abstract]
- Biol Futur. 2022 Dec;73(4):495-502. [Abstract]
- J Toxicol Sci. 2021;46(5):199-207. [Abstract]
- bioRxiv. 2025 Jul 30.
- Res Sq. 2025 May 28.
- Bioengineered. 2022 Feb;13(2):3486-3502. [Abstract]
- Oxid Med Cell Longev. 2020 Jul 1:2020:1605456. [Abstract]
Customer Validation & Images
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WB
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In Vivo Efficacy Study
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Histological Imaging/Staining
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In Vivo Efficacy Study
Biological Activity
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Cell Line
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Type | Value | Description | References |
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| MDA-MB-231 | IC50 |
54.98 μM
Compound: 3
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Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability after 24 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability after 24 hrs by MTT assay
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[PMID: 33581557] |
Salvianolic acid B (SA-B) 1 and 10 micromol/L decrease the cell active TGF-beta1 secretion by 63.3 % and 15.6 % of the control, down-regulat pro-collgen alpha1(I) mRNA expression to 77.0% and 51.8% respectively (P<0.05). SA-B 1 and 10 micromol/L also inhibit MAPK activity by 1 to 2 fold respectively.[3]
The degradation of Salvianolic acid B is temperature dependent. It was stable at 4oC for 30 h in aqueous solution. However, decomposition of Salvianolic acid B aqueous solution occurres automatically at 25oC, and is enhanced at 37, 65 and 100oC. On the other hand, Salvianolic acid B is also stable at 4, 25 and 37oC for 30 h in TPA (total phenolic acids).[4]
Salvianolic acid B is stable for 30 h in buffered phosphate aqueous solutions at pH 1.5, 3.0 and 5.0. With an increase of pH from the neutral, the stability of Sal B decreased.[4]
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 121521-90-2
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Appearance Solid
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Molecular Weight 718.61
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Formula C36H30O16
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Color Off-white to yellow
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SMILES
O=C([C@@H]1[C@@H](C2=CC=C(O)C(O)=C2)OC3=C(O)C=CC(/C=C/C(O[C@@H](C(O)=O)CC4=CC=C(O)C(O)=C4)=O)=C13)O[C@@H](C(O)=O)CC5=CC=C(O)C(O)=C5
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Synonyms
Lithospermic acid B
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years * The compound is unstable in solutions, freshly prepared is recommended.
Publications (21)
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Journal Impact Factor
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Most Recent
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Adv Sci (Weinh)
ZFPL1 Promotes Colorectal Cancer Progression by Stabilizing ASS1 to Drive the Urea Cycle and M2 Macrophage-Mediated Metastatic Colonization. [Abstract]2025 Dec;12(46):e05291. PMID: 41216870
Salvianolic acid B purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Dec;12(46):e05291. [Abstract]
Western blot analysis was conducted to detect the core kinase of ASS1 or ASS1‐K57mut in CRC cells treated with either DMSO or 100 µM Salvianolic acid B.
Salvianolic acid B purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Dec;12(46):e05291. [Abstract]
Co‐IP detected the ubiquitination level of ASS1 after treatment with DMSO or 100 µm Salcinolic acid B in CRC cells transfected with ASS1‐WT or ASS1‐K57mut.
Salvianolic acid B purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Dec;12(46):e05291. [Abstract]
The results revealed a significant reduction in tumor volume and weight in the Salvianolic acid B (Sal B) (10 mg/kg, i.p.)+anti‐PD‐1 group compared to the anti‐PD‐1 group.
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Cell Rep Med
CLDN4 palmitoylation promotes hepatic-to-biliary lineage transition and lenvatinib resistance in hepatocellular carcinoma. [Abstract]2025 Jul 15;6(7):102208. PMID: 40592346
Salvianolic acid B purchased from MedChemExpress. Usage Cited in: Cell Rep Med. 2025 Jul 15;6(7):102208. [Abstract]
Salvianolic acid B (SalB) (20 mg/kg, i.p.) reduced tumor growth in WT mice without significant liver toxicity by H&E and IHC.
Salvianolic acid B purchased from MedChemExpress. Usage Cited in: Cell Rep Med. 2025 Jul 15;6(7):102208. [Abstract]
Salvianolic acid B (SalB) (20 mg/kg, i.p.) reduced tumor growth in WT mice.
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J Neuroinflammation
THBS1 in macrophage-derived exosomes exacerbates cerebral ischemia-reperfusion injury by inducing ferroptosis in endothelial cells. [Abstract]2025 Feb 24;22(1):48. PMID: 39994679 -
Phytomedicine
Salvianolic acid B alleviates rheumatoid arthritis by inhibiting oxidative stress and pyroptosis through the Keap1-Nrf2/ROS/NLRP3 axis. [Abstract]2026 Jan:150:157736. PMID: 41456526 -
Phytomedicine
Fangchinoline suppresses nasopharyngeal carcinoma progression by inhibiting SQLE to regulate the PI3K/AKT pathway dysregulation. [Abstract]2025 May:140:156484. PMID: 40090046 -
Phytomedicine
Salvianolic acid B inhibits Ang II-induced VSMC proliferation in vitro and intimal hyperplasia in vivo by downregulating miR-146a expression. [Abstract]2019 May:58:152754. PMID: 31009837 -
Plant Physiol
Peroxisomal 4-coumaroyl-CoA ligases participate in shikonin production in Lithospermum erythrorhizon. [Abstract]2024 Jul 31;195(4):2843-2859. PMID: 38478427 -
Br J Pharmacol
Salvianolic acid B improves the microcirculation in a mouse model of sepsis through a mechanism involving the platelet receptor CD226. [Abstract]2025 Feb;182(4):988-1004. PMID: 39443080 -
Biomater Adv
Mechanical activation of lung epithelial cells through the ion channel Piezo1 activates the metalloproteinases ADAM10 and ADAM17 and promotes growth factor and adhesion molecule release. [Abstract]2023 Sep:152:213516. PMID: 37348330 -
Pharmaceuticals (Basel)
Bruceine D Identified as a Drug Candidate against Breast Cancer by a Novel Drug Selection Pipeline and Cell Viability Assay. [Abstract]2022 Jan 31;15(2):179. PMID: 35215292 -
Exp Neurol
Salvianolic acid B exerts cerebroprotective effects after traumatic brain injury via Nrf2-dependent antioxidant and anti-inflammatory cascades. [Abstract]2025 Sep:391:115305. PMID: 40383364 -
FASEB J
Nuclear Factor Erythroid 2-Related Factor 2-Dependent Ferroptosis Suppression by Salvianolic Acid B Preserves Microvascular Integrity and Reduces Risk Factors for Hemorrhagic Transformation After Cerebral Infarction. [Abstract]2026 May 31;40(10):e71826. PMID: 42186809 -
Biochim Biophys Acta Mol Cell Res
Hyperosmolarity-induced activation of PIEZO1 engages detrimental calcium/oxidative stress signaling and adaptive catalase response in renal inner medullary collecting duct (mIMCD3) cells. [Abstract]2025 Aug 7;1872(8):120041. PMID: 40780677 -
Arch Biochem Biophys
Targeting histidinol-phosphate aminotransferase in Acinetobacter baumannii with salvianolic acid B: A structure-based approach to novel antibacterial strategies. [Abstract]2025 Feb:764:110233. PMID: 39613285 -
Biochem Biophys Res Commun
Salvianolic acid B improved insulin resistance through suppression of hepatic ER stress in ob/ob mice. [Abstract]2020 Jun 4;526(3):733-737. PMID: 32265029 -
Biol Futur
The role of epigenetic modifiers in the hepatic differentiation of human umbilical cord derived mesenchymal stem cells. [Abstract]2022 Dec;73(4):495-502. PMID: 36512201 -
J Toxicol Sci
Salvianolic acid B attenuated cisplatin-induced cardiac injury and oxidative stress via modulating Nrf2 signal pathway. [Abstract]2021;46(5):199-207. PMID: 33952797 -
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Bioengineered
Salvianolic acid B alleviates diabetic endothelial and mitochondrial dysfunction by down-regulating apoptosis and mitophagy of endothelial cells. [Abstract]2022 Feb;13(2):3486-3502. PMID: 35068334 -
Oxid Med Cell Longev
Salvianolic Acid B Improves Postresuscitation Myocardial and Cerebral Outcomes in a Murine Model of Cardiac Arrest: Involvement of Nrf2 Signaling Pathway. [Abstract]2020 Jul 1:2020:1605456. PMID: 32714485
Salvianolic acid B purchased from MedChemExpress. Usage Cited in: Oxid Med Cell Longev. 2020 Jul 1:2020:1605456. [Abstract]
Expression of Keap1, nuclear and cytosolic Nrf2, HO-1, and NQO1 in the myocardium 3 hours following CA/CPR with or without Salvianolic acid B (Sal B) treatment. Salvianolic acid B (Sal B) treatment reduces ROS production via the activation of Nrf2 signaling pathway.
Solvent & Solubility
H2O : 50 mg/mL (69.58 mM; ultrasonic and adjust pH to 3 with HCl)
DMSO : 25 mg/mL (34.79 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (3.48 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (3.48 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 50 mg/mL (69.58 mM); Clear solution; Need ultrasonic
Add each solvent one by one: Saline
Solubility: ≥ 100 mg/mL (139.16 mM); Clear solution
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Purity & Documentation
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Data Sheet (282 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Antaris AL, et al. A small-molecule dye for NIR-II imaging. Nat Mater. 2016 Feb;15(2):235-42. [Content Brief]
[2]. Antaris AL, et al. A small-molecule dye for NIR-II imaging. Nat Mater. 2016 Feb;15(2):235-42. [Content Brief]
[3]. Antaris AL, et al. A small-molecule dye for NIR-II imaging. Nat Mater. 2016 Feb;15(2):235-42. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO / H2O | 1 mM | 1.3916 mL | 6.9579 mL | 13.9158 mL | 34.7894 mL |
| 5 mM | 0.2783 mL | 1.3916 mL | 2.7832 mL | 6.9579 mL | |
| 10 mM | 0.1392 mL | 0.6958 mL | 1.3916 mL | 3.4789 mL | |
| 15 mM | 0.0928 mL | 0.4639 mL | 0.9277 mL | 2.3193 mL | |
| 20 mM | 0.0696 mL | 0.3479 mL | 0.6958 mL | 1.7395 mL | |
| 25 mM | 0.0557 mL | 0.2783 mL | 0.5566 mL | 1.3916 mL | |
| 30 mM | 0.0464 mL | 0.2319 mL | 0.4639 mL | 1.1596 mL | |
| H2O | 40 mM | 0.0348 mL | 0.1739 mL | 0.3479 mL | 0.8697 mL |
| 50 mM | 0.0278 mL | 0.1392 mL | 0.2783 mL | 0.6958 mL | |
| 60 mM | 0.0232 mL | 0.1160 mL | 0.2319 mL | 0.5798 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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