Cat. No.: HY-N0106

(Rac)-Salvianic acid A sodium

(Synonyms: (Rac)-Danshensu sodium; (Rac)-Tanshinol sodium)

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

(Rac)-Salvianic acid A sodium is the racemic form of Salvianic acid A (HY-N1913). Salvianic acid A is an orally active phenolic compound that induces Nrf2/HO-1 activation and inhibits the NF-κB pathway, and it also activates the mitochondrial antioxidant defense system (Mitochondrial Metabolism). Salvianic acid A exhibits anti-inflammatory, antioxidant, and anti-apoptotic properties (Apoptosis), demonstrating potential for research into inflammation and cardiovascular diseases.

For research use only. We do not sell to patients.

Purity: 98.0%
CAS No.: 67920-52-9
Formula: C₉H₉NaO₅
Molecular Weight:220.15

Storage:

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

(Rac)-Salvianic acid A sodium Chemical Structure

CAS No.: 67920-52-9

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Publications (1)
Solvent & Solubility
- In Vitro
- In Vivo
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All NF-κB Isoforms :

In Vitro

Salvianic acid A (6-36 μM, 24 h) inhibits the decrease in vascular endothelial cell viability induced by Lipopolysaccharide (HY-D1056) in a dose-dependent manner^[6].
Salvianic acid A (10 or 20 μM, 24 h) inhibits Lipopolysaccharide (HY-D1056)-induced apoptosis through regulating glutathione peroxidase activity and malondialdehyde level in vascular endothelial cells^[6].
Salvianic acid A sodium (25 or 50 μM, 24 h) protects human umbilical vein endothelial cells against tert-butyl hydroperoxide induced oxidative injury via mitochondria-dependent pathway^[7].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[6]

Cell Line:

Lipopolysaccharide (HY-D1056)-induced human umbilical vein endothelial cells
Concentration:

6-36 μM
Incubation Time:

24 h
Result:

Inhibited the decrease in cell viability in a dose-dependent manner.

Apoptosis Analysis^[7]

Cell Line:

Tert-butyl hydroperoxide induced human umbilical vein endothelial cell
Concentration:

0, 25, 50, 100, 200 μM
Incubation Time:

24 h
Result:

Protected HUVEC cells against apoptosis induced by tert-butyl hydroperoxide.

Western Blot Analysis^[7]

Cell Line:

Tert-butyl hydroperoxide induced human umbilical vein endothelial cell
Concentration:

25 or 50 μM
Incubation Time:

24 h
Result:

Reversed the downregulation of MnSOD and Bcl-2 levels and the release of Cyt-c from mitochondria caused by tert-butyl hydroperoxide damage.

In Vivo

Salvianic acid A (3 or 10 mg/kg, p.o., once daily for 6 weeks) suppresses inflammatory reactions and inhibits oxidative stress in atherosclerosis (AS) rats induced by a high-fat diet, showing protective effects against atherosclerosis^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Atherosclerosis (AS) model induced by a high-fat diet in Sprague-Dawley rats (180-220 g)^[4]
Dosage:

3 or 10 mg/kg
Administration:

Oral gavage (p.o.), once daily for 6 weeks
Result:

Inhibited atherosclerotic lesion progression and reduced aortic lipid deposition by 58.2% and 72.8% in high-fat diet-induced AS rats.
Improved lipid profiles by lowering triglyceri/brdes, total cholesterol, and LDL cholesterol while significantly increasing HDL cholesterol in AS rats.
Enhanced antioxidant enzyme activity, upregulated the Nrf2/HO-1 pathway, and reduced the expression of p47phox and p22phox.

Chemical Information

CAS No. 67920-52-9
Appearance Solid
Molecular Weight 220.15
Formula C₉H₉NaO₅
Color White to off-white
SMILES

OC1=C(O)C=CC(CC(C(O[Na])=O)O)=C1
Synonyms

(Rac)-Danshensu sodium; (Rac)-Tanshinol sodium
Structure Classification
- Phenylpropanoids
- Simple Phenylpropanols
- Phenols
- Polyphenols
Initial Source
- Plants
- Labiatae
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Publications (1)

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Journal Impact Factor

Int Immunopharmacol

Albiflorin contributes to Xuebijing-mediated protection against sepsis-associated acute kidney injury by modulating the succinate-PFKFB3 immunometabolic axis. [Abstract]

2026 May 14:182:116841. PMID: 42134292

Solvent & Solubility

In Vitro:

H₂O : 100 mg/mL (454.24 mM; Need ultrasonic)

DMSO : 100 mg/mL (454.24 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

4.5424 mL

22.7118 mL

45.4236 mL

5 mM

0.9085 mL

4.5424 mL

9.0847 mL

10 mM

0.4542 mL

2.2712 mL

4.5424 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

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In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (11.36 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (11.36 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

Working Solution

For the following dissolution methods, please prepare the working solution directly:

It is recommended to prepare fresh solutions and use them promptly within a short period of time.

The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS

Solubility: 50 mg/mL (227.12 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Working solution concentration: 0.22 mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact

MedChemExpress (MCE) .

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (279 KB)
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Wei Wang, et al. Danshensu alleviates pseudo-typed SARS-CoV-2 induced mouse acute lung inflammation. Acta Pharmacol Sin. 2022 Apr;43(4):771-780. [Content Brief]

[2]. V Bharath Kumar, et al. Sodium Danshensu Inhibits Oral Cancer Cell Migration and Invasion by Modulating p38 Signaling Pathway. Front Endocrinol (Lausanne). 2020 Sep 30:11:568436. [Content Brief]

[3]. Chen Yu, et al. Danshensu attenuates cisplatin-induced nephrotoxicity through activation of Nrf2 pathway and inhibition of NF-κB. Biomed Pharmacother. 2021 Oct:142:111995. [Content Brief]

[4]. Wu Y, et al. The Effect of Salvianolic Acid on Vascular Protection and Possible Mechanisms. Oxid Med Cell Longev. 2020 Sep 25;2020:5472096. doi: 10.1155/2020/5472096. [Content Brief]

[5]. Zhao QT, et al. Salvianic acid A inhibits lipopolysaccharide-induced apoptosis through regulating glutathione peroxidase activity and malondialdehyde level in vascular endothelial cells. Chin J Nat Med. 2012 Jan;10(1):53-7. [Content Brief]

[6]. Jia D, et al. Salvianic acid A sodium protects HUVEC cells against tert-butyl hydroperoxide induced oxidative injury via mitochondria-dependent pathway. Chem Biol Interact. 2018 Jan 5;279:234-242. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
H₂O / DMSO	1 mM	4.5424 mL	22.7118 mL	45.4236 mL	113.5589 mL
	5 mM	0.9085 mL	4.5424 mL	9.0847 mL	22.7118 mL
	10 mM	0.4542 mL	2.2712 mL	4.5424 mL	11.3559 mL
	15 mM	0.3028 mL	1.5141 mL	3.0282 mL	7.5706 mL
	20 mM	0.2271 mL	1.1356 mL	2.2712 mL	5.6779 mL
	25 mM	0.1817 mL	0.9085 mL	1.8169 mL	4.5424 mL
	30 mM	0.1514 mL	0.7571 mL	1.5141 mL	3.7853 mL
	40 mM	0.1136 mL	0.5678 mL	1.1356 mL	2.8390 mL
	50 mM	0.0908 mL	0.4542 mL	0.9085 mL	2.2712 mL
	60 mM	0.0757 mL	0.3785 mL	0.7571 mL	1.8926 mL
	80 mM	0.0568 mL	0.2839 mL	0.5678 mL	1.4195 mL
	100 mM	0.0454 mL	0.2271 mL	0.4542 mL	1.1356 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

(Rac)-Salvianic acid A sodium

1 Cited Publications

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(Rac)-Salvianic acid A sodium

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Publications Citing Use of MedChemExpress (MCE) (Rac)-Salvianic acid A sodium

All NF-κB Isoforms

Biological Activity

Chemical Information

Publications (1)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

(Rac)-Salvianic acid A sodium Related Classifications

HY-N0106 Related Classifications