2. NF-κB Metabolic Enzyme/Protease Immunology/Inflammation Anti-infection Apoptosis
  3. Keap1-Nrf2 NF-κB Reactive Oxygen Species SARS-CoV Apoptosis
  4. Danshensu sodium

Danshensu sodium  (Synonyms: Dan shen suan A sodium; Salvianic acid A sodium)

Cat. No.: HY-N1913A
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Danshensu (Dan shen suan A) sodium, an orally active phenolic compound, can induce Nrf2/HO-1 activation and inhibition of NF-κB pathway. Danshensu sodium reduces reactive oxygen species (ROS) production, upregulates antioxidant defense mechanism and inhibits intrinsic apoptotic pathway. Danshensu sodium displays a potent antiviral activity against SARS-CoV-2 with EC50 of 0.97 μM. Danshensu sodium has anti-oxidation, anti-apoptosis, anti-lung inflammatory and has the potential for COVID-19, cardiovascular and cerebrovascular diseases research.

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Danshensu sodium Chemical Structure

Danshensu sodium Chemical Structure

CAS No. : 81075-52-7

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Description

Danshensu (Dan shen suan A) sodium, an orally active phenolic compound, can induce Nrf2/HO-1 activation and inhibition of NF-κB pathway. Danshensu sodium reduces reactive oxygen species (ROS) production, upregulates antioxidant defense mechanism and inhibits intrinsic apoptotic pathway. Danshensu sodium displays a potent antiviral activity against SARS-CoV-2 with EC50 of 0.97 μM. Danshensu sodium has anti-oxidation, anti-apoptosis, anti-lung inflammatory and has the potential for COVID-19, cardiovascular and cerebrovascular diseases research[1][2][3].

In Vitro

Danshensu (Dan shen suan A) sodium potently inhibits the entry of SARS-CoV-2 S protein-pseudo-typed virus (SARS-CoV-2 S) into ACE2-overexpressed HEK-293T cells (IC50=0.31 μM) and Vero-E6 cell (IC50=4.97 μM)[1].
Danshensu (0-100 μM; for 24 h) sodium at higher concentrations (50 and 100 μM) causes significant reduction in migration and invasion of both FaDu and Ca9-22 cells[2].
Danshensu (0-100 μM; for 24 h) sodium dose-dependently reduced the phosphorylation of ERK and p38 phosphorylation in FaDu cell[2].
Danshensu (0-100 μM; for 24, 48, 72 h) sodium does not have any cytotoxic effect on human oral cancer cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Danshensu sodium Related Antibodies

Cell Migration Assay [2]

Cell Line: FaDu and Ca9-22 cells
Concentration: 25, 50, and 100 μM
Incubation Time: 24 h
Result: At higher concentrations (50 and 100 μM) caused significant reduction in migration and invasion of both FaDu and Ca9-22 cells.

Western Blot Analysis[2]

Cell Line: FaDu and Ca9-22 cells
Concentration: 25, 50, and 100 μM
Incubation Time: 24 h
Result: Phosphorylation of ERK reduced dose-dependently after 24 h in FaDu cell.
Caused significant reduction in p38 phosphorylation.
In Vivo

Danshensu (Dan shen suan A; 25, 50, 100 mg/kg; oral administration daily for 7 continuous days or i.v. once) sodium before SARS-CoV-2 S infection dose-dependently alleviates the pathological alterations in mice infected with SARS-CoV-2 S[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult BALB/c mice (male, 6-8 weeks, 20±2 g)[1]
Dosage: 25, 50, 100 mg/kg
Administration: Oral administration (daily for 7 continuous days) or i.v. (once)
Result: Could prevent SARS-CoV-2 S protein-induced acute lung inflammation.
Ameliorated inflammatory cytokines in serum and lung tissue.
Molecular Weight

220.15

Formula

C9H9NaO5
CAS No.
SMILES

O=C(O[Na])[C@H](O)CC1=CC(O)=C(C=C1)O
Structure Classification
Initial Source
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
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Danshensu sodium Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Danshensu81075-52-7Dan shen suan ASalvianic acid AKeap1-Nrf2NF-κBReactive Oxygen SpeciesSARS-CoVApoptosisNuclear factor-κBNuclear factor-kappaBSARS coronavirusOrallyHO-1antioxidant defense mechanismanti-oxidationanti-apoptosislung inflammatoryCOVID-19cardiovascularcerebrovascularInhibitorinhibitorinhibit

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