Danshensu sodium
Based on 9 publication(s) in Google Scholar
Danshensu (Dan shen suan A) sodium, an orally active phenolic compound, can induce Nrf2/HO-1 activation and inhibition of NF-κB pathway. Danshensu sodium reduces reactive oxygen species (ROS) production, upregulates antioxidant defense mechanism and inhibits intrinsic apoptotic pathway. Danshensu sodium displays a potent antiviral activity against SARS-CoV-2 with EC50 of 0.97 μM. Danshensu sodium has anti-oxidation, anti-apoptosis, anti-lung inflammatory and has the potential for COVID-19, cardiovascular and cerebrovascular diseases research.
For research use only. We do not sell to patients.
- Purity: 99.9%
- CAS No.: 81075-52-7
- Formula: C9H9NaO5
- Molecular Weight:220.15
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Storage:
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Danshensu sodium
More- Phytomedicine. 2025 Feb:137:156378. [Abstract]
- Phytomedicine. 2023 May:113:154743. [Abstract]
- Food Sci Hum Wellness. 2025.
- Cancer Immunol Immunother. 2025 Jun 30;74(8):256. [Abstract]
- Eur J Pharmacol. 2025 Feb 1:177296. [Abstract]
- J Inflamm Res. 2026 Jun 19:19:596461. [Abstract]
- J Tradit Complement Med. 2025 Feb 7;15(4):434-445. [Abstract]
- Breast Cancer Res Treat. 2024 Dec;208(3):657-671. [Abstract]
- Vet Microbiol. 2026 May:316:110992. [Abstract]
Customer Validation & Images
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In Vivo Efficacy Study
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WB
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IF
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Histological Imaging/Staining
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IF
Biological Activity
Danshensu (Dan shen suan A) sodium potently inhibits the entry of SARS-CoV-2 S protein-pseudo-typed virus (SARS-CoV-2 S) into ACE2-overexpressed HEK-293T cells (IC50=0.31 μM) and Vero-E6 cell (IC50=4.97 μM)[1].
Danshensu (0-100 μM; for 24 h) sodium at higher concentrations (50 and 100 μM) causes significant reduction in migration and invasion of both FaDu and Ca9-22 cells[2].
Danshensu (0-100 μM; for 24 h) sodium dose-dependently reduced the phosphorylation of ERK and p38 phosphorylation in FaDu cell[2].
Danshensu (0-100 μM; for 24, 48, 72 h) sodium does not have any cytotoxic effect on human oral cancer cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:FaDu and Ca9-22 cells
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Concentration:25, 50, and 100 μM
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Incubation Time:24 h
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Result:At higher concentrations (50 and 100 μM) caused significant reduction in migration and invasion of both FaDu and Ca9-22 cells.
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Cell Line:FaDu and Ca9-22 cells
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Concentration:25, 50, and 100 μM
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Incubation Time:24 h
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Result:Phosphorylation of ERK reduced dose-dependently after 24 h in FaDu cell.
Caused significant reduction in p38 phosphorylation.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Adult BALB/c mice (male, 6-8 weeks, 20±2 g)[1]
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Dosage:25, 50, 100 mg/kg
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Administration:Oral administration (daily for 7 continuous days) or i.v. (once)
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Result:Could prevent SARS-CoV-2 S protein-induced acute lung inflammation.
Ameliorated inflammatory cytokines in serum and lung tissue.
Chemical Information
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CAS No. 81075-52-7
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Appearance Solid
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Molecular Weight 220.15
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Formula C9H9NaO5
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Color Off-white to light yellow
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SMILES
O=C(O[Na])[C@H](O)CC1=CC(O)=C(C=C1)O
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Synonyms
Dan shen suan A sodium; Salvianic acid A sodium
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Publications (9)
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Journal Impact Factor
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Most Recent
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Phytomedicine
Danshensu enhances autophagy and reduces inflammation by downregulating TNF-α to inhibit the NF-κB signaling pathway in ischemic flaps. [Abstract]2025 Feb:137:156378. PMID: 39818119
Danshensu sodium purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 Feb:137:156378. [Abstract]
Danshensu (DSS；40, 60 mg/kg; IP; daily for 7 days) significantly increased the flap survival rate in the C57BL/6J mouse.
Danshensu sodium purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 Feb:137:156378. [Abstract]
Danshensu (DSS；40, 60 mg/kg; IP; daily for 7 days) increased the protein expression of Cadherin5, MMP9, and VEGFA in the C57BL/6J mouse. Representative western blot images of Cadherin5, MMP9, and VEGFA in mouse skin tissue lysates, with density quantification and statistical analysis of protein levels in each group.
Danshensu sodium purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 Feb:137:156378. [Abstract]
Danshensu (DSS; 40, 60 mg/kg; IP; daily for 7 days) showed the number of blood vessels significantly decreased after ischemic injury of the skin flap. This result was reversed with the use of DSS.
Danshensu sodium purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 Feb:137:156378. [Abstract]
Danshensu (DSS; 40, 60 mg/kg; IP; daily for 7 days) increased average vessel density in mouse.
Danshensu sodium purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 Feb:137:156378. [Abstract]
Danshensu (DSS; 40, 60 mg/kg; IP; daily for 7 days) showed that the proportion of GSDMD-N and Caspase-1 positive cells was considerably higher following ischemic injury of the skin flap and notably reduced after DSS treatment. Immunofluorescence staining of Caspase-1 (red) on skin tissue sections from each group, with DAPI staining for cell nuclei (blue).
Danshensu sodium purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 Feb:137:156378. [Abstract]
Danshensu (DSS; 40, 60 mg/kg; IP; daily for 7 days) decreased the protein expression of GSDMD-N and Caspase-1 in C57BL/6 J mice.
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Phytomedicine
Anti-inflammatory effect of Danhong injection through inhibition of GSDMD-mediated pyroptosis. [Abstract]2023 May:113:154743. PMID: 36893672 -
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Cancer Immunol Immunother
Salvianic acid A enhances anti-PD-1 therapy by promoting HEV-mediated stem-like CD8 T cells infiltration in TNBC. [Abstract]2025 Jun 30;74(8):256. PMID: 40586931 -
Eur J Pharmacol
Sodium Danshensu alleviates bone cancer pain by inhibiting the osteoclast differentiation and CGRP expression. [Abstract]2025 Feb 1:177296. PMID: 39900329 -
J Inflamm Res
Salvianic Acid A Regulates Ferroptosis by Activating the Nrf2-GPX4 Pathway Through EGFR to Protect Myocardial Ischemia-Reperfusion Injury. [Abstract]2026 Jun 19:19:596461. PMID: 42345001 -
J Tradit Complement Med
Salvianic acid A promotes osteogenic differentiation of bone marrow mesenchymal stem cells in senile osteoporosis through bromodomain-containing protein 4/Ariadne RBR E3 ubiquitin-protein ligase 1/Rubicon axis. [Abstract]2025 Feb 7;15(4):434-445. PMID: 40677544 -
Breast Cancer Res Treat
Phosphoenolpyruvate carboxykinase-2 (PCK2) is a therapeutic target in triple-negative breast cancer. [Abstract]2024 Dec;208(3):657-671. PMID: 39177932 -
Vet Microbiol
The Chinese medicine monomer Schisandrin C inhibits PRRSV infection by regulating the OGT-PI3K/AKT/mTOR signaling pathway. [Abstract]2026 May:316:110992. PMID: 41865607
Solvent & Solubility
H2O : 50 mg/mL (227.12 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (278 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Wei Wang, et al. Danshensu alleviates pseudo-typed SARS-CoV-2 induced mouse acute lung inflammation. Acta Pharmacol Sin. 2022 Apr;43(4):771-780. [Content Brief]
[2]. V Bharath Kumar, et al. Sodium Danshensu Inhibits Oral Cancer Cell Migration and Invasion by Modulating p38 Signaling Pathway. Front Endocrinol (Lausanne). 2020 Sep 30:11:568436. [Content Brief]
[3]. Chen Yu, et al. Danshensu attenuates cisplatin-induced nephrotoxicity through activation of Nrf2 pathway and inhibition of NF-κB. Biomed Pharmacother. 2021 Oct:142:111995. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| H2O | 1 mM | 4.5424 mL | 22.7118 mL | 45.4236 mL | 113.5589 mL |
| 5 mM | 0.9085 mL | 4.5424 mL | 9.0847 mL | 22.7118 mL | |
| 10 mM | 0.4542 mL | 2.2712 mL | 4.5424 mL | 11.3559 mL | |
| 15 mM | 0.3028 mL | 1.5141 mL | 3.0282 mL | 7.5706 mL | |
| 20 mM | 0.2271 mL | 1.1356 mL | 2.2712 mL | 5.6779 mL | |
| 25 mM | 0.1817 mL | 0.9085 mL | 1.8169 mL | 4.5424 mL | |
| 30 mM | 0.1514 mL | 0.7571 mL | 1.5141 mL | 3.7853 mL | |
| 40 mM | 0.1136 mL | 0.5678 mL | 1.1356 mL | 2.8390 mL | |
| 50 mM | 0.0908 mL | 0.4542 mL | 0.9085 mL | 2.2712 mL | |
| 60 mM | 0.0757 mL | 0.3785 mL | 0.7571 mL | 1.8926 mL | |
| 80 mM | 0.0568 mL | 0.2839 mL | 0.5678 mL | 1.4195 mL | |
| 100 mM | 0.0454 mL | 0.2271 mL | 0.4542 mL | 1.1356 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Danshensu sodium Related Classifications
HY-N1913A Related Classifications
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