2. NF-κB Metabolic Enzyme/Protease Immunology/Inflammation Anti-infection Apoptosis
  3. Keap1-Nrf2 NF-κB Reactive Oxygen Species (ROS) SARS-CoV Apoptosis
  4. Danshensu sodium

Danshensu sodium  (Synonyms: Dan shen suan A sodium; Salvianic acid A sodium)

Cat. No.: HY-N1913A Purity: 99.9%
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Danshensu (Dan shen suan A) sodium, an orally active phenolic compound, can induce Nrf2/HO-1 activation and inhibition of NF-κB pathway. Danshensu sodium reduces reactive oxygen species (ROS) production, upregulates antioxidant defense mechanism and inhibits intrinsic apoptotic pathway. Danshensu sodium displays a potent antiviral activity against SARS-CoV-2 with EC50 of 0.97 μM. Danshensu sodium has anti-oxidation, anti-apoptosis, anti-lung inflammatory and has the potential for COVID-19, cardiovascular and cerebrovascular diseases research.

For research use only. We do not sell to patients.

CAS No. : 81075-52-7

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Based on 8 publication(s) in Google Scholar

Other Forms of Danshensu sodium:

Danshensu sodium Related Antibodies

Top Publications Citing Use of Products

    Danshensu sodium purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 Feb:137:156378.  [Abstract]

    Danshensu (DSS；40, 60 mg/kg; IP; daily for 7 days) significantly increased the flap survival rate in the C57BL/6J mouse.

    Danshensu sodium purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 Feb:137:156378.  [Abstract]

    Danshensu (DSS；40, 60 mg/kg; IP; daily for 7 days) increased the protein expression of Cadherin5, MMP9, and VEGFA in the C57BL/6J mouse. Representative western blot images of Cadherin5, MMP9, and VEGFA in mouse skin tissue lysates, with density quantification and statistical analysis of protein levels in each group.

    Danshensu sodium purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 Feb:137:156378.  [Abstract]

    Danshensu (DSS; 40, 60 mg/kg; IP; daily for 7 days) showed the number of blood vessels significantly decreased after ischemic injury of the skin flap. This result was reversed with the use of DSS.

    Danshensu sodium purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 Feb:137:156378.  [Abstract]

    Danshensu (DSS; 40, 60 mg/kg; IP; daily for 7 days) increased average vessel density in mouse.

    Danshensu sodium purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 Feb:137:156378.  [Abstract]

    Danshensu (DSS; 40, 60 mg/kg; IP; daily for 7 days) showed that the proportion of GSDMD-N and Caspase-1 positive cells was considerably higher following ischemic injury of the skin flap and notably reduced after DSS treatment. Immunofluorescence staining of Caspase-1 (red) on skin tissue sections from each group, with DAPI staining for cell nuclei (blue).

    Danshensu sodium purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 Feb:137:156378.  [Abstract]

    Danshensu (DSS; 40, 60 mg/kg; IP; daily for 7 days) decreased the protein expression of GSDMD-N and Caspase-1 in C57BL/6 J mice.

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    Description

    Danshensu (Dan shen suan A) sodium, an orally active phenolic compound, can induce Nrf2/HO-1 activation and inhibition of NF-κB pathway. Danshensu sodium reduces reactive oxygen species (ROS) production, upregulates antioxidant defense mechanism and inhibits intrinsic apoptotic pathway. Danshensu sodium displays a potent antiviral activity against SARS-CoV-2 with EC50 of 0.97 μM. Danshensu sodium has anti-oxidation, anti-apoptosis, anti-lung inflammatory and has the potential for COVID-19, cardiovascular and cerebrovascular diseases research[1][2][3].

    In Vitro

    Danshensu (Dan shen suan A) sodium potently inhibits the entry of SARS-CoV-2 S protein-pseudo-typed virus (SARS-CoV-2 S) into ACE2-overexpressed HEK-293T cells (IC50=0.31 μM) and Vero-E6 cell (IC50=4.97 μM)[1].
    Danshensu (0-100 μM; for 24 h) sodium at higher concentrations (50 and 100 μM) causes significant reduction in migration and invasion of both FaDu and Ca9-22 cells[2].
    Danshensu (0-100 μM; for 24 h) sodium dose-dependently reduced the phosphorylation of ERK and p38 phosphorylation in FaDu cell[2].
    Danshensu (0-100 μM; for 24, 48, 72 h) sodium does not have any cytotoxic effect on human oral cancer cells[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Danshensu sodium Related Antibodies

    Cell Migration Assay [2]

    Cell Line: FaDu and Ca9-22 cells
    Concentration: 25, 50, and 100 μM
    Incubation Time: 24 h
    Result: At higher concentrations (50 and 100 μM) caused significant reduction in migration and invasion of both FaDu and Ca9-22 cells.

    Western Blot Analysis[2]

    Cell Line: FaDu and Ca9-22 cells
    Concentration: 25, 50, and 100 μM
    Incubation Time: 24 h
    Result: Phosphorylation of ERK reduced dose-dependently after 24 h in FaDu cell.
    Caused significant reduction in p38 phosphorylation.
    In Vivo

    Danshensu (Dan shen suan A; 25, 50, 100 mg/kg; oral administration daily for 7 continuous days or i.v. once) sodium before SARS-CoV-2 S infection dose-dependently alleviates the pathological alterations in mice infected with SARS-CoV-2 S[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Adult BALB/c mice (male, 6-8 weeks, 20±2 g)[1]
    Dosage: 25, 50, 100 mg/kg
    Administration: Oral administration (daily for 7 continuous days) or i.v. (once)
    Result: Could prevent SARS-CoV-2 S protein-induced acute lung inflammation.
    Ameliorated inflammatory cytokines in serum and lung tissue.
    Molecular Weight

    220.15

    Formula

    C9H9NaO5
    CAS No.
    Appearance

    Solid

    Color

    Off-white to light yellow

    SMILES

    O=C(O[Na])[C@H](O)CC1=CC(O)=C(C=C1)O
    Structure Classification
    Initial Source
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    -20°C, protect from light, stored under nitrogen

    *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

    Solvent & Solubility
    In Vitro: 

    H2O : 50 mg/mL (227.12 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 4.5424 mL 22.7118 mL 45.4236 mL
    5 mM 0.9085 mL 4.5424 mL 9.0847 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

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    Please enter the basic information of animal experiments:

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    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
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    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Purity & Documentation

    Purity: 99.9%

    SDS (393 KB)

    COA (247 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 4.5424 mL 22.7118 mL 45.4236 mL 113.5589 mL
    5 mM 0.9085 mL 4.5424 mL 9.0847 mL 22.7118 mL
    10 mM 0.4542 mL 2.2712 mL 4.5424 mL 11.3559 mL
    15 mM 0.3028 mL 1.5141 mL 3.0282 mL 7.5706 mL
    20 mM 0.2271 mL 1.1356 mL 2.2712 mL 5.6779 mL
    25 mM 0.1817 mL 0.9085 mL 1.8169 mL 4.5424 mL
    30 mM 0.1514 mL 0.7571 mL 1.5141 mL 3.7853 mL
    40 mM 0.1136 mL 0.5678 mL 1.1356 mL 2.8390 mL
    50 mM 0.0908 mL 0.4542 mL 0.9085 mL 2.2712 mL
    60 mM 0.0757 mL 0.3785 mL 0.7571 mL 1.8926 mL
    80 mM 0.0568 mL 0.2839 mL 0.5678 mL 1.4195 mL
    100 mM 0.0454 mL 0.2271 mL 0.4542 mL 1.1356 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    Danshensu sodium Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Danshensu81075-52-7Dan shen suan ASalvianic acid AKeap1-Nrf2NF-κBReactive Oxygen Species (ROS)SARS-CoVApoptosisNuclear factor-κBNuclear factor-kappaBSARS coronavirusOrallyHO-1antioxidant defense mechanismanti-oxidationanti-apoptosislung inflammatoryCOVID-19cardiovascularcerebrovascularInhibitorinhibitorinhibit

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