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  3. Chlorogenic acid

Chlorogenic acid  (Synonyms: 3-O-Caffeoylquinic acid; Heriguard; NSC-407296)

Cat. No.: HY-N0055 Purity: 99.35%
COA Handling Instructions

Chlorogenic acid is a major phenolic compound in Lonicera japonica Thunb. It is an orally active antioxidant activity, antibacterial, hepatoprotective, cardioprotective, anti-inflammatory, antipyretic, neuroprotective, anti-obesity, antiviral, anti-microbial, anti-hypertension compound.

For research use only. We do not sell to patients.

Chlorogenic acid Chemical Structure

Chlorogenic acid Chemical Structure

CAS No. : 327-97-9

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10 mM * 1 mL in DMSO
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Customer Review

Based on 14 publication(s) in Google Scholar

Other Forms of Chlorogenic acid:

Top Publications Citing Use of Products

    Chlorogenic acid purchased from MedChemExpress. Usage Cited in: Int J Med Microbiol. 2023 Jan 24.

    Chlorogenic acid (CGA; 50 μg/mL; 1 h) inhibits the Klebsiella pneumoniae (Kp)-induced increase in p38 expression levels as well as increases in p-p38/p-38 and p-MK2/MK2 levels, in RLE6TN cells.

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    • Biological Activity

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    Description

    Chlorogenic acid is a major phenolic compound in Lonicera japonica Thunb. It is an orally active antioxidant activity, antibacterial, hepatoprotective, cardioprotective, anti-inflammatory, antipyretic, neuroprotective, anti-obesity, antiviral, anti-microbial, anti-hypertension compound[1][2][3].

    In Vitro

    Chlorogenic acid (10 μM, 16 h) decreases HIF-1α protein levels in CoCl2 induced hypoxic A549 cells, but does not affect HIF-1α mRNA level[1].
    Chlorogenic acid (10 μM, 24 h) inhibits the hypoxia-induced HUVEC cell migration, invasion and tube formation of vascular endothelial cells[1].
    Chlorogenic acid (25, 50 μM, 24 h) inhibits cell proliferation of Huh7 cells, and reduces the number of invading and migrating cells[4].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    In Vivo

    Chlorogenic acid (10 μM, s.c.) inhibits VEGF (200 ng/mL)-induced angiogenesis in C57BL/6J mice, by suppression of AKT activation (Matrigel plug assay)[1].
    Chlorogenic acid (10-100 mg/kg, p.o.) shows protective effects against experimental reflux esophagitis in rats[3].
    Chlorogenic acid (10 mg/kg, i.v.) prevents endotoxic mortality and induced TNF-α release of LPS-intoxicated C57BL/6 mice, and ameliorates acute liver injury of LPS/GalN-challenged mice[2].
    Chlorogenic acid (ip, 25-200 mg/kg) inhibits tumor growth in NOD/SCID mice inoculated with Huh7 or H446 cells[4].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Experimental reflux esophagitis (RE) in rats[1]
    Dosage: 10, 30, 100 mg/kg
    Administration: p.o.
    Result: Reduced esophageal lipid peroxidation (marker: MDA) and increased the reduced glutathione/oxidized glutathione ratio.
    Inhibited the increases in the serum level of TNF-α, and expressions of iNOS and COX-2 protein.
    Animal Model: LPS/GalN-challenged mice[2]
    Dosage: 10 mg/kg
    Administration: i.v.
    Result: Increased survival rates of LPS/GalN-intoxicated mice.
    Inhibited LPS/GalN-induced phosphorylation of NF-κB p65 or c-Jun, without affecting p-IRF3 levels in the liver lobules.
    Clinical Trial
    Molecular Weight

    354.31

    Formula

    C16H18O9

    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    O=C([C@@]1(O)C[C@@H](OC(/C=C/C2=CC=C(O)C(O)=C2)=O)[C@H](O)[C@H](O)C1)O

    Structure Classification
    Initial Source
    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 1 year
    -20°C 6 months
    Solvent & Solubility
    In Vitro: 

    DMSO : 100 mg/mL (282.24 mM; Need ultrasonic)

    H2O : ≥ 20 mg/mL (56.45 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.8224 mL 14.1119 mL 28.2239 mL
    5 mM 0.5645 mL 2.8224 mL 5.6448 mL
    10 mM 0.2822 mL 1.4112 mL 2.8224 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2.5 mg/mL (7.06 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 2.5 mg/mL (7.06 mM); Clear solution

    • 3.

      Add each solvent one by one:  10% DMSO    90% Corn Oil

      Solubility: ≥ 2.5 mg/mL (7.06 mM); Clear solution

    *All of the co-solvents are available by MedChemExpress (MCE).
    Purity & Documentation

    Purity: 99.55%

    References
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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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    Product Name:
    Chlorogenic acid
    Cat. No.:
    HY-N0055
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