trans-Chlorogenic acid
trans-Chlorogenic acid (trans-3-O-Caffeoylquinic acid) is a caffeoyl ester derivative of quinic acid, as well as an oviposition stimulant. trans-Chlorogenic acid can be found in the leaves of carrot (Daucus carota) and wild parsnip (Pastinaca sativa).
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 202650-88-2
- 分子式: C16H18O9
- 分子量:354.31
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| BMDC | IC50 |
>50 μM
Compound: 4
|
Inhibition of LPS-induced IL-12 p40 production in wild-type C57BL/6 mouse BMDC pretreated with compound for 1 hr before LPS treatment measured 16 hrs by ELISA
Inhibition of LPS-induced IL-12 p40 production in wild-type C57BL/6 mouse BMDC pretreated with compound for 1 hr before LPS treatment measured 16 hrs by ELISA
|
[PMID: 25769817] |
| BMDM | IC50 |
86 μM
Compound: Chlorogenic acid
|
Inhibition of M-CSF/RANKL-induced osteoclast differentiation in C57BL/6 mouse bone marrow macrophage assessed as reduction in multinucleated TRAP+ cells incubated for 6 days with fresh media replacement on day 3 and measured on day 6 by TRAP staining-base
Inhibition of M-CSF/RANKL-induced osteoclast differentiation in C57BL/6 mouse bone marrow macrophage assessed as reduction in multinucleated TRAP+ cells incubated for 6 days with fresh media replacement on day 3 and measured on day 6 by TRAP staining-base
|
[PMID: 31257875] |
| HCT-116 | IC50 |
367 μM
Compound: chlorogenic acid
|
Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay
Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay
|
[PMID: 12880319] |
| HeLa | IC50 |
375 μM
Compound: 26
|
Inhibition of HDAC in human Hela cells nuclear extracts by fluorimetric assay
Inhibition of HDAC in human Hela cells nuclear extracts by fluorimetric assay
|
[PMID: 19520580] |
| HeLa | IC50 |
>200 μM
Compound: Chlorogenic acid
|
Inhibition of HDAC in human HeLa cells using Boc-Lys(AC)-AMC as substrate after 24 to 48 hrs by spectrofluorometry
Inhibition of HDAC in human HeLa cells using Boc-Lys(AC)-AMC as substrate after 24 to 48 hrs by spectrofluorometry
|
[PMID: 26996372] |
| MT2 | ED50 |
>497 μM
Compound: chlorogenic acid
|
Concentration that inhibits Human Immunodeficiency Virus Type 1 (HIV-1)-induced death of MT-2 cells
Concentration that inhibits Human Immunodeficiency Virus Type 1 (HIV-1)-induced death of MT-2 cells
|
[PMID: 9986720] |
| SW480 | IC50 |
353 μM
Compound: chlorogenic acid
|
Cytotoxicity against human SW480 cells after 72 hrs by MTT assay
Cytotoxicity against human SW480 cells after 72 hrs by MTT assay
|
[PMID: 12880319] |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Papilio polyxenes (female adults)[2]
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Dosage:4.8 μg; 48 μg; 480 μg
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Administration:topical application to filter paper strips
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Result:Significantly increased the oviposition response rate of female Papilio polyxenes in a dose‑dependent manner.
Showed strong synergistic activity with tyramine and neutral plant fractions to trigger full oviposition behavior, while it had weak to moderate activity alone.
化学情報
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CAS 番号 202650-88-2
-
分子量 354.31
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分子式 C16H18O9
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SMILES
OC(C=C1/C=C/C(O[C@@H]2C[C@@](O)(C[C@H]([C@H]2O)O)C(O)=O)=O)=C(C=C1)O
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別名
trans-3-O-Caffeoylquinic acid; trans-Heriguard; trans-NSC-407296
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)