Hypericum perforatum Linn.

Protohypericin is a compound that can be extracted from Hypericum perforatum. Protohypericin has low photocytotoxicity but can be efficiently photoconverted into Hypericin (HY-N0453) with high phototoxicity under visible light. Protohypericin can be used in cancer research.

Furohyperforin is a natural product isolated from Hypericum perforatum L., possessing neuroprotective and antidepressant activities. Furohyperforin acts as an NLRP3 inflammasome inhibitor and also exhibits inhibitory effects on recombinant CYP3A4. Furohyperforin exerts neuroprotective effects against corticosterone-induced neuronal damage. Furohyperforin inhibits the NLRP3 inflammasome cascade and its downstream IL‑1β and GSDMD signaling pathways, and also reduces serum corticosterone levels in mice, regulating HPA axis function. Furohyperforin is applicable for depression-related research.

Adlupulone (Phloroglucinol impurity X) is an antibacterial agent with an MIC of 0.98 μg/mL and an MBC of 3.91 μg/mL against Bacillus subtilis. Adlupulone is found in auxin-induced root cultures of Hypericum perforatum and in female flowers of hops (Humulus lupulus L.). Adlupulone can be used in research related to Bacillus subtilis infection.

trans-Chlorogenic acid (trans-3-O-Caffeoylquinic acid) is a caffeoyl ester derivative of quinic acid, as well as an oviposition stimulant. trans-Chlorogenic acid can be found in the leaves of carrot (Daucus carota) and wild parsnip (Pastinaca sativa).

Assiguxanthone B is a natural xanthone.

Hyperidione D is apotent antidepressant agent. Hyperidione D shows neuroprotective effects.

Protohypericin is a compound that can be extracted from Hypericum perforatum. Protohypericin has low photocytotoxicity but can be efficiently photoconverted into Hypericin (HY-N0453) with high phototoxicity under visible light. Protohypericin can be used in cancer research.

8-Hydroxyhyperforin 8,1-hemiacetal, a monoterpenoid, is a hyperforin oxidized product.