Adlupulone
Adlupulone (Phloroglucinol impurity X) is an antibacterial agent with an MIC of 0.98 μg/mL and an MBC of 3.91 μg/mL against Bacillus subtilis. Adlupulone is found in auxin-induced root cultures of Hypericum perforatum and in female flowers of hops (Humulus lupulus L.). Adlupulone can be used in research related to Bacillus subtilis infection.
For research use only. We do not sell to patients.
- CAS No.: 31769-60-5
- Formula: C26H38O4
- Molecular Weight:414.59
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
Adlupulone (16-24 h) potently inhibits and kills Bacillus subtilis ATCC6051 in vitro with an MIC of 0.98 μg/mL and MBC of 3.91 μg/mL, and contributes moderately to the antibacterial activity of HHT hop extract with an AAV of 0.80[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 31769-60-5
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Molecular Weight 414.59
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Formula C26H38O4
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SMILES
O=C(C=1C(O)=C(C(=O)C(C1O)(CC=C(C)C)CC=C(C)C)CC=C(C)C)C(C)CC
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Synonyms
Phloroglucinol impurity X
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Research Protocol for Infectious Diseases
Infectious-disease experiments test how pathogens interact with host barriers, innate immune receptors, inflammatory signaling, pathogen replication, and tissue injury; pattern-recognition receptors such as TLRs, RIG-I-like receptors, NOD-like receptors, and inflammasomes detect microbial molecules and activate NF-κB, interferon, and cytokine responses. The central hypothesis is that infection severity reflects the balance between pathogen burden and host response: protective inflammation restricts pathogen growth, whereas excessive or mislocalized inflammation contributes to tissue damage and disease phenotype. Unresolved questions include which host pathways are protective versus pathogenic, why some infection models fail to translate to human disease, and which combined readouts best predict clinically relevant infection outcomes.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Adlupulone Related Classifications
HY-Z15599 Related Classifications
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