2. Disease Areas
  3. Infection
  4. Bacterial Infection
  5. Bacillus Subtilis Infection

Bacillus Subtilis Infection

Bacillus subtilis infection is rare but can occur in immunocompromised individuals or following invasive procedures, with clinical manifestations ranging from localized infections to systemic disease. The bacterium's ability to form highly resistant spores enables survival under harsh conditions, contributing to its persistence in the environment and potential for nosocomial transmission. While primarily considered a non-pathogenic organism with widespread use in biotechnology, B. subtilis has been associated with opportunistic infections such as endophthalmitis, bacteremia, and pneumonia, particularly in patients with underlying health conditions or indwelling medical devices. These infections are often challenging to treat due to the inherent resistance of spores and potential antibiotic tolerance of biofilm-forming strains. Early diagnosis and appropriate antimicrobial therapy are crucial for favorable outcomes.

Bacillus Subtilis Infection (19):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-P2729
    Subtilisin 9014-01-1
    Subtilisin (EC 3.4.21.14) is a bacterial serine protease. Subtilisin induces Apoptosis. Subtilisin stimulates the expression of pro-allergic cytokines (IL-1α, IL-33). Subtilisin induces prototypic allergic lung inflammation. Subtilisin exhibits anticancer activity against breast and colon cancer. Subtilisin shows antifouling activity. Subtilisin can be used as a detergent additive.
    Subtilisin
  • HY-118773
    MreB Perturbing Compound A22 hydrochloride 22816-60-0 99.97%
    MreB Perturbing Compound A22 hydrochloride (A22 hydrochloride) is a reversible MreB inhibitor and antimicrobial agent that exhibits bacteriostatic activity against Escherichia coli, with low activity against Gram-positive bacteria. MreB Perturbing Compound A22 hydrochloride rapidly and reversally delocalizes MreB from the helical/circular structures in cells, impairs MreB function, and reduces the binding of MreB to the chromosomal region proximal to the replication origin. MreB Perturbing Compound A22 hydrochloride alters the cell morphology of caulobacters to round/lemon-shaped, slows caulobacter growth, blocks their cell division, and induces the formation of spherical morphology, asymmetric division, and anucleate cells in Escherichia coli. MreB Perturbing Compound A22 hydrochloride is used for studies related to bacterial rod-shaped morphology determination, chromosome segregation, and cell division mechanisms.
    MreB Perturbing Compound A22 hydrochloride
  • HY-110354
    UCM05 1094451-90-7 99.22%
    UCM05 (G28UCM) is a fatty acid synthase (FASN) and filamentous temperature-sensitive protein Z (Ftsz) inhibitor. UCM05 inhibits fatty acid synthesis, viral replication, and Gram-positive bacterial growth. UCM05 binds to FtsZ GTP-binding sites, inhibits GTPase activity, and disrupts Z-ring localization. UCM05 can be used for the research of HSV-1/2 infection, HIV-1 infection, and Gram-positive bacterial infections[1][2][3].
    UCM05
  • HY-W104527
    2,4-Dinitrobenzenesulfonamide 73901-01-6
    2,4-Dinitrobenzenesulfonamide (Compound 2d) is an antibacterial and antifungal agent. 2,4-Dinitrobenzenesulfonamide interacts with dihydrofolate synthetase. 2,4-Dinitrobenzenesulfonamide shows inhibitory effect against A. niger, C. albicans, B. subtilis, and S. aureus.
    2,4-Dinitrobenzenesulfonamide
  • HY-183305
    Antibiofilm-IN-1
    Antibiofilm-IN-1 (Compound 10) is a biofilm inhibitor and Antibacterial agent. Antibiofilm-IN-1 potently inhibits biofilm formation by Staphylococcus aureus, Bacillus subtilis, Escherichia coli and Pseudomonas aeruginosa.
    Antibiofilm-IN-1
  • HY-137502A
    ML267 free base 1542213-03-5
    ML267 free base is a blood-brain barrier permeable Antibacterial agent and bacterial phosphopantetheinyl transferase (PPTase) inhibitor, with an IC50 of 0.29 μM against Bacillus subtilis Sfp-PPTase and an IC50 of 8.1 μM against bacterial AcpS-PPTase. ML267 free base attenuates bacterial secondary metabolism, activity, and the production of Sfp-PPTase-dependent metabolites. ML267 free base inhibits the growth of Gram-positive bacteria, including Methicillin (HY-121544)-resistant Staphylococcus aureus. ML267 free base is applicable to research related to bacterial infections, including methicillin-resistant Staphylococcus aureus infections.
    ML267 free base
  • HY-149456
    Xanthoangelol F 265652-71-9
    Xanthoangelol F is a prenylated (geranylated) chalcone and Antibacterial agent. Xanthoangelol F can be isolated from Angelica keiskei. Xanthoangelol F inhibits the growth of Gram-positive bacteria Bacillus subtilis, Staphylococcus epidermidis, and Micrococcus luteus, with an MIC of 64 μg/mL.
    Xanthoangelol F
  • HY-112027
    Decarboxy ciprofloxacin 105394-83-0
    Decarboxy ciprofloxacin (Decarboxylated ciprofloxacin) is an antibacterial agent. Decarboxy ciprofloxacin displays antibacterial activities against Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus faecalis, Bacillus subtilis, Enterobacter cloacae, Serratia marcescens and especially potent activity against Escherichia coli.
    Decarboxy ciprofloxacin
  • HY-119555
    Nifurpipone 24632-47-1
    Nifurpipone is an orally active broad-spectrum antimicrobial agent. Nifurpipone acts against Gram-positive and Gram-negative bacteria, and reduces bacterial loads in systemic, intramuscular and urinary tract infections in mouse models. Nifurpipone can be used in studies related to bacterial infections.
    Nifurpipone
  • HY-P11630
    ZM-804
    ZM-804 is a cationic α-helix antimicrobial peptide. ZM-804 targets bacterial cell membranes. ZM-804 demonstrates antimicrobial activity and prevents the infection of tomato plants by Pst DC3000. ZM-804 inhibits the growth of B. subtilis and E. coli (the same MICs of 41.10 μg/mL). ZM-804 exhibits low hemolytic activity.
    ZM-804
  • HY-N17734
    2-Deethoxy-2-hydroxyphantomolin 821799-76-2
    2-Deethoxy-2-hydroxyphantomolin, Germacranolide, is an Antifungal and Antibacterial agent. 2-Deethoxy-2-hydroxyphantomolin can be isolated from Elephantopus tomentosus Linn and E. mollis. 2-Deethoxy-2-hydroxyphantomolin is moderately active against Candida albicans (14 mm clearing zone) and slightly active against Escherichia coli (12 mm), Pseudomonas aeruginosa (12 mm), Bacillus subtilis (14 mm), and Trichophyton mentagrophytes (13 mm).
    2-Deethoxy-2-hydroxyphantomolin
  • HY-150583
    Chitin synthase inhibitor 2 2416338-24-2
    Chitin synthase inhibitor 2 (compound 2b) is a potent inhibitor of chitin synthase with the IC50 value of 0.09 mM and the Ki value of 0.12 mM. Chitin synthase inhibitor 2 has antimicrobial activities in vitro and shows synergistic or additive effects with fluconazole or polyoxin B.
    Chitin synthase inhibitor 2
  • HY-N19224
    Pulvinic acid dilactone 6273-79-6
    Pulvinic acid dilactone (Compound 1) is a pulvinic acid derivative and Antibacterial agent. Pulvinic acid dilactone can be isolated from the lichen Candelaria concolor. Pulvinic acid dilactone moderately inhibits the growth of Bacillus subtilis. Pulvinic acid dilactone exerts positive inotropic effects. Pulvinic acid dilactone can be used in studies related to Bacillus subtilis infections and leukemia.
    Pulvinic acid dilactone
  • HY-182488
    Pulvinamide 31673-63-9
    Pulvinamide is a tetronic acid pigment, a pulvinic acid derivative, an Antibacterial agent and Antifungal agent. Pulvinamide can be isolated from lichens. Pulvinamide weakly inhibits the growth of Bacillus subtilis (ATCC 6633) with an MIC of 50 μg/mL. Pulvinamide weakly inhibits the growth of Candida albicans (ATCC 10231) and Saccharomyces cerevisiae (ATCC 9763), with MIC values of 200 μg/mL and 100 μg/mL, respectively.
    Pulvinamide
  • HY-181686
    Antibacterial agent 326
    Antibacterial agent 326 is a bactericide that inhibits the growth of various bacterial strains. Antibacterial agent 326 inhibits biofilm formation in Escherichia coli, disrupts bacterial cell membranes, induces oxidative stress and lipid peroxidation in Escherichia coli, increases ROS levels, and reduces GSH activity. Antibacterial agent 326 can be used in studies of bacterial infections, including those caused by Escherichia coli, Staphylococcus aureus, Enterococcus faecalis, Listeria spp., Bacillus subtilis, Serratia marcescens, Salmonella enteritidis and Acinetobacter calcoaceticus.
    Antibacterial agent 326
  • HY-180125A
    Antibacterial agent 307 hydrochloride
    Antibacterial agent 307 hydrochloride is an antibacterial agent. Antibacterial agent 307 hydrochloride shows MICs of 1-4 μg/mL against Gram-positive bacteria, moderate activity against Gram-negative bacteria, low hemolytic toxicity, and excellent plasma stability. Antibacterial agent 307 hydrochloride compromises bacterial membrane integrity via increased permeability and depolarization, induces endogenous ROS accumulation, causes cytoplasmic protein and nucleic acid leakage, and drives rapid bacterial cell death. Antibacterial agent 307 hydrochloride can be used for the research of bacterial infection.
    Antibacterial agent 307 hydrochloride
  • HY-W289542
    N-(2-Pyridyl)nicotinamide 13160-07-1
    N-(2-Pyridyl)nicotinamide (Compound 3i) is an anti-biofilm agent. N-(2-Pyridyl)nicotinamide inhibits the formation of Bacillus subtilis biofilms.
    N-(2-Pyridyl)nicotinamide
  • HY-N14359
    Megovalicin B 89759-26-2
    Megovalicin B has the effect against subtilis and E.coli.
    Megovalicin B
  • HY-138075
    Obafluorin 92121-68-1 99.9%
    Obafluorin is a β-lactone antibiotic. Obafluorin inhibits threonyl-tRNA synthetase (PfThrRS) with an IC50 of 4.3 nM. Obafluorin inhibits the aminoacylation activity of EcThrRS and ObaO. Obafluorin exhibits Fe3+-enhanced antibacterial activity. Obafluorin can be used in studies related to infections caused by bacterial and parasites such as Plasmodium.
    Obafluorin