Xanthoangelol F 

Xanthoangelol F is a prenylated (geranylated) chalcone and Antibacterial agent. Xanthoangelol F can be isolated from Angelica keiskei. Xanthoangelol F inhibits the growth of Gram-positive bacteria Bacillus subtilis, Staphylococcus epidermidis, and Micrococcus luteus, with an MIC of 64 μg/mL^[1][2].

Xanthoangelol F (20 μM) does not inhibit the SaeRS two-component system in Staphylococcus aureus USA300-Phlam-GFP strain^[1].
Xanthoangelol F (1-256 μg/mL; 48 h) inhibits the growth of Gram-positive Bacillus subtilis, Staphylococcus epidermidis, and Micrococcus luteus with an MIC of 64 μg/mL, and shows no activity against tested Gram-negative bacteria^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

406.52

C₂₆H₃₀O₄

265652-71-9

C(/C=C(/CCC=C(C)C)\C)C1=C(OC)C=CC(C(/C=C/C2=CC=C(O)C=C2)=O)=C1O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Mizar P, et al. Total Synthesis of Xanthoangelol B and Its Various Fragments: Toward Inhibition of Virulence Factor Production of Staphylococcus aureus. J Med Chem. 2018;61(23):10473-10487.

  [2]. Sugamoto K, et al. Synthesis and antibacterial activity of chalcones bearing prenyl or geranyl groups from Angelica keiskei[J]. Tetrahedron, 2011, 67(29): 5346-5359.