Antibacterial agent 326 

Antibacterial agent 326 is a bactericide that inhibits the growth of various bacterial strains. Antibacterial agent 326 inhibits biofilm formation in Escherichia coli, disrupts bacterial cell membranes, induces oxidative stress and lipid peroxidation in Escherichia coli, increases ROS levels, and reduces GSH activity. Antibacterial agent 326 can be used in studies of bacterial infections, including those caused by Escherichia coli, Staphylococcus aureus, Enterococcus faecalis, Listeria spp., Bacillus subtilis, Serratia marcescens, Salmonella enteritidis and Acinetobacter calcoaceticus^[1].

Antibacterial agent 326 (Compound 12) at concentrations of 1.56-3.12 μg/mL inhibits the growth of S. aureus, E. faecalis, L. species, B. subtilis, S. marcescens, E. coli, S. enterica, and A. calcoaceticu, with MIC values of 1.56, 1.56, 3.12, 1.56, 3.23, 1.56, 3.12, and 1.56 μg/mL, respectively^[1].
Antibacterial agent 326 produces an inhibition zone of 22.7 mm against Escherichia coli in the agar disk diffusion assay, exhibiting strong antibacterial activity^[1].
Antibacterial agent 326 (0-12.5 μg/mL; up to 660 min) exhibits rapid, concentration-dependent bactericidal activity against E. coli, inhibits E. coli biofilm formation, increases the inner membrane permeability of E. coli, disrupts the membrane integrity of E. coli, and depolarizes the cell membrane of E. coli^[1].
Antibacterial agent 326 (1.56-12.5 μg/mL) induces concentration-dependent metabolic dysfunction in E. coli, triggers intracellular oxidative stress, elevates ROS levels, impairs the cellular antioxidant defense system, and reduces GSH activity^[1].
Antibacterial agent 326 (12.5 μg/mL) induces lipid peroxidation and increases MDA production in Escherichia coli^[1].
Antibacterial agent 326 disrupts the cellular morphology of E. coli, causing wrinkles, shrinkage, collapse, and fragmentation on its surface^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

489.39

C₂₄H₁₇BrN₄OS

C=CCN(C1=C2C=C(Br)C=C1)C=C2/C=C(S/3)\C(NC3=N\C4=C(N=CC=C5)C5=CC=C4)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Sharma P, et al. Targeting drug-resistant E. coli with quinoline-thiazolidinone derivatives: A new avenue for combating antibacterial resistance from molecular design to mechanistic action. Eur J Med Chem. 2026;301:118233.  [Content Brief]