2. PI3K/Akt/mTOR
  3. PI3K
  4. AZD8154

AZD8154 is a novel inhaled selective PI3Kγδ dual inhibitor targeting airway inflammatory disease.

For research use only. We do not sell to patients.

AZD8154 Chemical Structure

AZD8154 Chemical Structure

CAS No. : 2215022-45-8

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 715 In-stock
Solution
10 mM * 1 mL in DMSO USD 715 In-stock
Solid
5 mg USD 650 In-stock
10 mg USD 980 In-stock
25 mg USD 2050 In-stock
50 mg USD 3300 In-stock
100 mg USD 5300 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

AZD8154 Related Antibodies

Top Publications Citing Use of Products

View All PI3K Isoform Specific Products:

View All Isoforms
PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

AZD8154 is a novel inhaled selective PI3Kγδ dual inhibitor targeting airway inflammatory disease.

IC50 & Target

PI3Kγ

 

Clinical Trial
Molecular Weight

551.68

Formula

C27H29N5O4S2
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

CS(=O)(C1=C2C(CN(C2=O)[C@H](C3CC3)C)=CC(C4=C(C)N=C(NC5=CC=CC(N6C(CCC6)=O)=N5)S4)=C1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (45.32 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8126 mL 9.0632 mL 18.1265 mL
5 mM 0.3625 mL 1.8126 mL 3.6253 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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mg/kg

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(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8126 mL 9.0632 mL 18.1265 mL 45.3161 mL
5 mM 0.3625 mL 1.8126 mL 3.6253 mL 9.0632 mL
10 mM 0.1813 mL 0.9063 mL 1.8126 mL 4.5316 mL
15 mM 0.1208 mL 0.6042 mL 1.2084 mL 3.0211 mL
20 mM 0.0906 mL 0.4532 mL 0.9063 mL 2.2658 mL
25 mM 0.0725 mL 0.3625 mL 0.7251 mL 1.8126 mL
30 mM 0.0604 mL 0.3021 mL 0.6042 mL 1.5105 mL
40 mM 0.0453 mL 0.2266 mL 0.4532 mL 1.1329 mL
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AZD8154 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AZD81542215022-45-8AZD 8154AZD-8154PI3KPhosphoinositide 3-kinaseInhibitorinhibitorinhibit

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