2215022-45-8
2215022-45-8
Chemical Structure
AZD8154
- CAS No.: 2215022-45-8
- Formula:C27H29N5O4S2
- Molecular Weight:551.68
IUPAC Name: (S)-2-(1-cyclopropylethyl)-5-(4-methyl-2-((6-(2-oxopyrrolidin-1-yl)pyridin-2-yl)amino)thiazol-5-yl)-7-(methylsulfonyl)isoindolin-1-one
InChIKey: XOMFDZJQLSPGGV-INIZCTEOSA-N
SMILES: CS(=O)(C1=C2C(CN(C2=O)[C@H](C3CC3)C)=CC(C4=C(C)N=C(NC5=CC=CC(N6C(CCC6)=O)=N5)S4)=C1)=O
Biological Activity: AZD8154 is a selective PI3Kγδ dual inhibitor. AZD8154 can suppress PI3Kγ and PI3Kδ signaling pathway activation. AZD8154 can be used for the researches of inflammation and immunology, such as asthma[1][2].
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AZD8154 | 99.88% | AZD8154 is a selective PI3Kγδ dual inhibitor. AZD8154 can suppress PI3Kγ and PI3Kδ signaling pathway activation. AZD8154 can be used for the researches of inflammation and immunology, such as asthma. | ||||||||||||||||||||
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References
- [1]. Pinkerton JW, et al. PI3Kγδ inhibition suppresses key disease features in a rat model of asthma. Respir Res. 2024 Apr 23;25(1):175. [Content Brief]
- [2]. Sadiq MW, et al. Characterisation of pharmacokinetics, safety and tolerability in a first-in-human study for AZD8154, a novel inhaled selective PI3Kγδ dual inhibitor targeting airway inflammatory disease. Br J Clin Pharmacol. 2022 Jan;88(1):260-270. [Content Brief]
Keywords
