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Cat. No.: HY-158001

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MHC00188

MHC00188 is an allosteric inhibitor for Autotaxin (ATX) with an IC₅₀ of 2.53 μM.

For research use only. We do not sell to patients.

CAS No.: 1380881-85-5
Formula: C₂₂H₂₆N₆OS
Molecular Weight:422.55

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

MHC00188 Chemical Structure

CAS No.: 1380881-85-5

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

MHC00188 is an allosteric inhibitor for Autotaxin (ATX) with an IC₅₀ of 2.53 μM^[1].

IC₅₀ & Target

Autotaxin

All Phosphodiesterase (PDE) Isoforms :

Chemical Information

CAS No. 1380881-85-5
Molecular Weight 422.55
Formula C₂₂H₂₆N₆OS
SMILES

CC1=C(SC(NC2=CC=CC(C3CCCN3C(C4=NNC5=C4CCCC5)=O)=N2)=N1)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Stylianaki EA, et al., Identification of two novel chemical classes of Autotaxin (ATX) inhibitors using Enalos Asclepios KNIME nodes. Bioorg Med Chem Lett. 2024 Mar 5;103:129690. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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MHC00188

All Phosphodiesterase (PDE) Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

MHC00188 Related Classifications

HY-158001 Related Classifications