1. Signaling Pathways
  2. Metabolic Enzyme/Protease
  3. Phosphodiesterase (PDE)
  4. Phosphodiesterase (PDE) Inhibitors

Phosphodiesterase (PDE) Inhibitors

PDE1

PDE2

PDE3

PDE4

PDE5

PDE6

PDE7

PDE9

PDE10

PDE11

PDE12

PDE8

Autotaxin

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Phosphodiesterase (PDE) Inhibitors, Activators & Modulators
Product Name PDE1 PDE2 PDE3 PDE4 PDE5 PDE6 PDE7 PDE9 PDE10 PDE11 PDE12 PDE8 Autotaxin Purity
IBMX    
PDE3
PDE4
                  99.99%
Rolipram      
PDE4
                  99.58%
Roflumilast      
PDE4
                  99.98%
Sildenafil        
PDE5
                99.97%
PDE7-IN-3            
PDE7
            99.24%
Theophylline (Standard)    
PDE3
                   
Apremilast      
PDE4, IC50: 74 nM
                  99.91%
Theophylline    
PDE3
                    99.89%
Icariin      
PDE4, IC50: 73.5 μM
PDE5, IC50: 432 nM
                99.06%
Milrinone    
PDE3
                    99.87%
Tadalafil        
PDE5
                99.92%
Zatolmilast      
PDE4D3, IC50: 7.4 nM
PDE4D7, IC50: 7.8 nM
                  98.98%
ITI-214
PDE1, Ki: 58 pM
PDE1A, Ki: 33 pM
PDE1B, Ki: 380 pM
PDE1C, Ki: 35 pM
                        99.54%
Ziritaxestat                        
Autotaxin, IC50: 131 nM
Autotaxin, Ki: 15 nM
99.29%
EHNA hydrochloride  
hPDE2A, IC50: 0.8 μM
                      99.61%
Ro 20-1724      
PDE4, Ki: 1930 nM
                  99.34%
PF-8380                        
Autotaxin, IC50: 2.8 nM (In isolated enzyme assay)
99.04%
Sildenafil citrate        
PDE5
                99.73%
Crisaborole      
PDE4
                 
Bay 60-7550  
PDE2
                      98.14%
Edelinontrine              
PDE9
          98.74%
Butein      
PDE4, IC50: 10.4 μM
                  99.95%
Zaprinast        
PDE5
                99.95%
DNMDP    
PDE3
                    98.95%
FPFT-2216          
PDE6D
              99.35%
Avanafil
PDE1, IC50: 53000 nM
PDE2, IC50: 51000 nM
 
PDE4, IC50: 5700 nM
PDE5, IC50: 5.2 nM
PDE6, IC50: 630 nM
PDE7, IC50: 27000 nM
 
PDE10, IC50: 6200 nM
        ≥98.0%
Moracin M      
PDE4D2, IC50: 2.9 μM
PDE4B2, IC50: 4.5 μM
PDE5A1, IC50: >40 μM
   
PDE9A2, IC50: >100 μM
          98.90%
MR-L2      
PDE4
                  99.23%
Vardenafil
PDE1, IC50: 180 nM
 
PDE3, IC50: >1000 nM
PDE4, IC50: >1000 nM
PDE5, IC50: 0.7 nM
PDE6, IC50: 11 nM
              99.58%
Zardaverine    
PDE3
PDE4
                  98.73%
BAY 2666605    
PDE3A, IC50: 87 nM
PDE3B, IC50: 50 nM
                    99.64%
GSK256066      
PDE4, IC50: 3.2 pM
                  98.15%
Difamilast      
PDE4B, IC50: 11.2 nM
                  99.63%
Mirodenafil dihydrochloride        
PDE5
                99.85%
Cilomilast      
LPDE4, IC50: ~100 nM
HPDE4, IC50: 120 nM
                  99.89%
HA130                        
Autotaxin, IC50: 28 nM
99.46%
PF-05180999  
PDE2A, IC50: 1.6 nM
       
PDE7B, IC50: 50.09 μM
 
PDE10A1, IC50: 2.03 μM
PDE11A4, IC50: 26.969 μM
      99.97%
BC11-38                  
PDE11, IC50: 0.28 μM
      98.13%
Vardenafil hydrochloride
PDE1, IC50: 180 nM
 
PDE3, IC50: >1000 nM
PDE4, IC50: >1000 nM
PDE5, IC50: 0.7 nM
PDE6, IC50: 11 nM
              99.48%
PDE4B-IN-2      
PDE4B, IC50: 15 nM
PDE4D, IC50: 1.7 μM
                  99.21%
Tovinontrine
PDE1A3, : 88.4 nM
PDE1B, : 8.48 nM
PDE1C, : 12.2 nM
     
PDE5A2, : 81.9 nM
   
PDE9A1, : 8.19 nM
PDE9A2, : 9.99 nM
          99.83%
BAY 73-6691              
PDE9
          99.84%
TMX-4100          
PDE6D
PDE6
              98.42%
PF-05085727  
PDE2A, IC50: 2 nM
                      99.60%
Roflupram      
PDE4, IC50: 26.2 nM
                  99.61%
Ensifentrine    
PDE3, IC50: 0.4 nM
PDE4, IC50: 1479 nM
                  99.78%
TyK2-IN-2      
PDE4, IC50: 62 nM
                  98.64%
Orismilast      
PDE4B3, IC50: 3 nM
PDE4D7, IC50: 3 nM
PDE4D5, IC50: 3 nM
PDE4B2, IC50: 6 nM
PDE4D3, IC50: 8 nM
PDE4D4, IC50: 8 nM
PDE4D1, IC50: 9 nM
PDE4D2, IC50: 9 nM
PDE4A4, IC50: 11 nM
PDE4B1, IC50: 16 nM
PDE4A1, IC50: 16 nM
PDE4A10, IC50: 52 nM
PDE4C2, IC50: 104 nM
                  99.37%
PDE4B-IN-3      
PDE4B, IC50: .94 μM
                  99.40%
Osoresnontrine
PDE1C, IC50: 1 μM
PDE1A, IC50: 1.4 μM
           
PDE9A, IC50: 52 nM
          99.88%
PF-04449613              
PDE9A, IC50: 22 nM
          99.83%
PDE1-IN-2
PDE1A, IC50: 164 nM
PDE1B, IC50: 140 nM
PDE1C, IC50: 6 nM
                        ≥98.0%
(S)-(+)-Rolipram      
PDE4, IC50: 1100 nM
                  99.77%
GSK356278      
PDE4A, pIC50: 8.6
PDE4B, pIC50: 8.8
PDE4D, pIC50: 8.7
                  99.89%
Lodenafil        
PDE5
                99.81%
OR-1896    
PDE3/PDE Ⅲ
                    99.03%
Glaucine      
PDE4
                  99.57%
Irsogladine      
PDE4
                  99.97%
TAK-915
PDE1A, IC50: 2497 nM
PDE2A, IC50: 0.61 nM
                      99.74%
TMX-4113          
PDE6D
              98.66%
CM-675        
PDE5, IC50: 114 nM nM
                99.45%
Piclamilast
PDE1, IC50: >100 μM
PDE2, IC50: 40 μM
PDE3, IC50: >100 μM
PDE4, IC50: 16 nM (in pig aorta)
PDE4, IC50: 2 nM (in eosinophil soluble)
PDE5, IC50: 14 μM
                99.63%
Enoximone    
PDE3/PDE Ⅲ, IC50: 5.9 μM
PDE4A, IC50: 21.1 μM (myocardial PDE4A)
                  98.07%
Mardepodect hydrochloride                
PDE10
       
MK-8189                
PDE10A, Ki: 29 pM
        99.88%
Dovramilast      
PDE4
PDE4
                  99.83%
FCPR03      
PDE4 catalytic domain, IC50: 60 nM
PDE4B1, IC50: 31 nM
PDE4D7, IC50: 47 nM
                  99.82%
Thioquinapiperifil dihydrochloride
PDE1, IC50: 380 nM
PDE2, IC50: 670 nM
PDE3, IC50: 38 nM
PDE4, IC50: 800 nM
PDE5, IC50: 0.074 nM
                99.22%
Oglemilast      
PDE4D3, IC50: .5 nM
                  98.00%
PAT-505                        
Autotaxin, IC50: 2 nM (In Hep3B cells)
Autotaxin, IC50: 9.7 nM (In human blood )
Autotaxin, IC50: 62 nM (In mouse plasma)
99.47%
PDE12-IN-3                    
PDE12, pXC50: 7.68
    99.43%
MY-5445      
PDE4, IC50: 37 μM
PDE5, IC50: 6.7 μM
PDE5, Ki: 1.3 μM
                99.86%
PF-06445974      
PDE4B, IC50: <1 nM
PDE4D, IC50: 36 nM
PDE4A, IC50: 4.7 nM
PDE4C, IC50: 17 nM
                  98.23%
CI-1044      
PDE4A5, IC50: 0.29 μM
PDE4B2, IC50: 0.08 μM
PDE4C2, IC50: 0.56 μM
PDE4D3, IC50: 0.09 μM
                  98.03%
Sp-cAMPS sodium salt    
PDE3A, Ki: 47.6 μM
         
PDE10 GAF domain, EC50: 50 μM
        98.73%
Mirodenafil        
PDE5
                99.70%
Autotaxin modulator 1                        
Autotaxin
98.93%
K-Ras-PDEδ-IN-1      
PDE4, Kd: 8.3 nM
                  99.62%
PDE12-IN-1                    
PDE12, pIC50: 9.1
    99.23%
Autotaxin-IN-3                        
Autotaxin, IC50: 2.4 nM
98.24%
MBCQ
PDE Ⅰ, IC50: >100 μM
PDE Ⅱ, IC50: >100 μM
PDE Ⅲ, IC50: >100 μM
PDE Ⅳ, IC50: >100 μM
PDE V, IC50: 19 nM
                99.37%
RS-25344 hydrochloride
PDE Ⅰ, IC50: >100 μM
PDE Ⅱ, IC50: 160 μM
PDE Ⅲ, IC50: 330 μM
PDE Ⅳ, IC50: 0.28 nM
                  99.50%
Nortadalafil        
PDE5
                99.77%
Motapizone    
PDE3
                   
PQ-10                
PDE10A, IC50: 4.6 nM
        99.77%
PDE10A-IN-2 hydrochloride                
PDE10A, IC50: 2.8 nM
        98.43%
BRD9500    
PDE3A, IC50: 10 nM
PDE3B, IC50: 27 nM
                    99.46%
LEO 39652      
PDE4D, IC50: 3.8 nM
PDE4A, IC50: 1.2 nM
PDE4B, IC50: 1.2 nM
PDE4C2, IC50: 3.0 nM
                  99.51%
ATX inhibitor 5                        
Autotaxin
99.20%
PDE5-IN-7
PDE1, IC50: 300 nM
     
PDE5, IC50: 5 nM
                99.59%
Fenspiride hydrochloride    
PDE3
PDE4
PDE5
                99.97%
Sp-cAMPS    
PDE3A, Ki: 47.6 μM
         
PDE10 GAF domain, EC50: 50 μM
       
Kuraridine        
PDE5, IC50: 0.64 μM
                ≥98.0%
Sildenafil-d3        
PDE5
                99.79%
Ayanin  
PDE2A
 
PDE4
                  98.00%
Gisadenafil besylate
PDE1A, IC50: 9.1 μM
     
PDE5A, IC50: 3.6 nM
                ≥99.0%
PDE2/PDE10-IN-1  
hPDE2A, IC50: 29 nM
 
hPDE4D, IC50: 5890 nM
       
rPDE10A, IC50: 480 nM
hPDE11A, IC50: 6920 nM
      99.88%
AN3199      
PDE4, IC50: 94.5 nM
                  99.67%
Tetomilast      
PDE4
                  ≥98.0%
ent-Tadalafil        
PDE5, IC50: 10 μM
                98.14%
Lirimilast      
PDE4, IC50: 42 nM
                  98.69%
BIO-32546                        
Autotaxin
99.05%
PDE9-IN-1              
PDE9A, IC50: 8.7 nM
          99.70%
BW-A 78U      
PDE4, IC50: 3 μM
                  99.67%
PDE4-IN-4      
PDE4
                 
Robustine        
PDE5A
                99.97%
Lodenafil carbonate        
PDE5
                ≥98.0%
MK-0952      
PDE4, IC50: 0.53 nM
                  99.71%
Yonkenafil hydrochloride        
PDE5
                99.43%
Sophoflavescenol        
PDE5
                98.15%
PDE10-IN-1                
PDE10
        99.44%
T-0156
PDE1, IC50: >100 μM
PDE2, IC50: >100 μM
PDE3, IC50: >100 μM
PDE4, IC50: 63 μM
PDE5, IC50: 0.23 nM
PDE6, IC50: 56 nM
             
S32826 disodium                        
Autotaxin, IC50: 8.8 nM
99.23%
PF-8380 hydrochloride                        
Autotaxin, IC50: 2.8 nM (In isolated enzyme assay)
98.59%
ITI-214 free base
PDE1, Ki: 58 pM
PDE1A, Ki: 33 pM
PDE1B, Ki: 380 pM
PDE1C, Ki: 35 pM
                        ≥98.0%
PF-07038124      
PDE4B2, IC50: 0.5 nM
                 
LASSBio-1632      
PDE4A
PDE4D
                 
Vardenafil dihydrochloride
PDE1, IC50: 180 nM
     
PDE5, IC50: 0.7 nM
PDE6, IC50: 11 nM
             
Avanafil dibenzenesulfonate
PDE1, IC50: 53000 nM
PDE2, IC50: 51000 nM
 
PDE4, IC50: 5700 nM
PDE5, IC50: 5.2 nM
PDE6, IC50: 630 nM
PDE7, IC50: 27000 nM
 
PDE10, IC50: 6200 nM
       
TPN729MA
PDE1, IC50: 566 nM
   
PDE4, IC50: 834 nM
PDE5, IC50: 2.28 nM
PDE6, IC50: 45.2 nM
     
PDE11, IC50: 6090 nM
      99.45%
TPN729
PDE1, IC50: 566 nM
   
PDE4, IC50: 834 nM
PDE5, IC50: 2.28 nM
PDE6, IC50: 45.2 nM
     
PDE11, IC50: 6090 nM
     
Autotaxin-IN-4                        
Autotaxin
PDE5-IN-2  
PDE2A, IC50: 106 nM
 
PDE4D2, IC50: 43 nM
PDE5A1, IC50: 0.31 nM
PDE6C, IC50: 1.2 nM
   
PDE10A, IC50: 46 nM
       
TPN171        
PDE5, IC50: 0.62 nM
                99.41%
BAY-7081              
PDE9A, IC50: 15 nM
         
MT-3014                
human PDE 10A, IC50: 0.062 nM
bovine PDE 10A, IC50: 0.09 nM
       
Sp-cAMPS triethylamine    
PDE3A, Ki: 47.6 μM
         
PDE10 GAF domain, EC50: 50 μM
       
(S)-C33
PDE1B, IC50: 554 ± 64 nM
PDE2A, IC50: 2.4 ± 0.5 μM
 
PDE4D2, IC50: 1.3 ± 0.1 μM
PDE5A1, IC50: 366 ± 38 nM
   
PDE9A, IC50: 11 ± 4 nM
PDE10A1, IC50: 2.3 ± 0.3 μM
       
Gemlapodect                
PDE10A
       
PDE11-IN-1                  
PDE11
      98.23%
PDE4-IN-6      
PDE4B, IC50: 0.125 μM
PDE4D, IC50: 0.43 μM
                 
Thioquinapiperifil
PDE1, IC50: 380 nM
PDE2, IC50: 670 nM
PDE3, IC50: 38 nM
PDE4, IC50: 800 nM
PDE5, IC50: 0.074 nM
               
Deltazinone 1          
PDEδ, Kd: 8 nM
             
PDE11A4-IN-1                  
PDE11A4, IC50: 12 nM
     
S32826                        
Autotaxin, IC50: 8.8 nM
PDE5-IN-3        
PDE5, IC50: 1.57 nM
               
Z21090      
PDE4, IC50: 37.4 nM
                 
PF-03049423 free base        
PDE5A
               
ATX inhibitor 18                        
Autotaxin, IC50: 24.2 nM
Toddacoumalone      
PDE4
                 
PDE4-IN-12      
PDE4D2, IC50: 3.51 nM
PDE4B2, IC50: 9.51 nM
PDE5A1, IC50: 1.24 μM
 
PDE7A, IC50: 15 nM
 
PDE10A, IC50: 1.02 μM
   
PDE8A1, IC50: 194 nM
 
FR-229934        
PDE V
                98.65%
Gisadenafil
PDE1A, IC50: 9.1 μM
     
PDE5A, IC50: 3.6 nM
               
(R)-Irsenontrine              
PDE9, IC50: 0.041 μM
          99.00%
PDE5-IN-9        
PDE5
                ≥98.0%
ATX inhibitor 20                        
Autotaxin, IC50: 2.3 ± 0.31 nM
ATX inhibitor 15                        
Autotaxin, IC50: 2.17 nM
PDE5/HDAC-IN-1        
PDE5, IC50: 46.3 nM
               
Norbraylin      
PDE4D2, IC50: 7.15 μM
                 
N-Methylbenzamide                
PDE10A
        99.82%
ATX inhibitor 12                        
Autotaxin, IC50: 1.72 nM
Atizoram      
PDE4
                 
Anagrelide hydrochloride monohydrate    
PDE3
                   
PDE3B-IN-1    
PDE3B, IC50: 6.5 μM
                   
PDE4-IN-11      
PDE4
                 
ATX inhibitor 19                        
Autotaxin, IC50: 156 ± 19.8 nM
ATX inhibitor 14                        
Autotaxin, IC50: 0.41 nM
PDE2A-IN-1  
PDE2
                     
Arofylline      
PDE4
                 
Ilexsaponin B2
PDEI, IC50: 477.5 μM
     
PDE5, IC50: 48.8 μM
               
Autotaxin-IN-1                        
Autotaxin, IC50: 2 nM
ATX inhibitor 8                        
Autotaxin
Icariin (Standard)      
PDE4
PDE5
               
Acetildenafil        
PDE5
               
PDE7-IN-2            
PDE7A, IC50: 2.1 μM
           
PDE5-IN-10        
PDE5, IC50: 20 nM
               
JNJ-42314415                
human PDE 10A, Ki: 35 nM
       
1,3,5-Trihydroxy-4-prenylxanthone        
PDE5, IC50: 3 μM
               
PF-00489791        
PDE5A, IC50: 5 nM
               
Mesembrine      
PDE4B, IC50: 7.8 μM
                 
cis-Tadalafil        
PDE5, IC50: 0.09 μM
               
CDP-840      
PDE4
                 
Autotaxin-IN-5                        
Autotaxin
Fenspiride    
PDE3
PDE4
PDE5
               
Etazolate hydrochloride      
PDE4, IC50: 2 μM
                 
PDE4-IN-5      
PDE4
                 
Autotaxin-IN-6                        
Autotaxin, IC50: 30 nM
MHC00188                        
Autotaxin
ATX inhibitor 11                        
Autotaxin, IC50: 2.7 ± 1 nM
PDE5-IN-4        
PDE5
               
PDE4-IN-8      
PDE4B2, IC50: 0.93 nM
                 
Avanafil-13C,d3
PDE1
                       
Mesopram      
PDE4
                 
Theophylline sodium acetate    
PDE3
                   
PDE4-IN-13      
PDE4, IC50: 1.56 μM
                 
TC-E 5005  
PDE2A, IC50: 239 nM
PDE3A, IC50: 3700 nM
 
PDE5A, IC50: 919 nM
 
PDE7B, IC50: 3100 nM
 
PDE10A, IC50: 7.28 nM
hPDE11A, IC50: 779 nM
     
PDE4B/7A-IN-1      
PDE4
   
PDE7
           
AChE/PDE4-IN-1      
PDE4, IC50: 1.88 μM
                 
PDE4B/7A-IN-2      
PDE4
   
PDE7
           
PDE5-IN-5        
PDE5, IC50: 2.0 nM
               
ATX inhibitor 21                        
Autotaxin, IC50: 3490 ± 170 nM
L-869298      
PDE4A, IC50: 0.5 nM
                 
PDE5-IN-12        
PDE5, IC50: 22 nM
               
PF-03049423        
PDE5A
               
PDE1-IN-4
PDE1C, IC50: 10 ± 3 nM
PDE1A, IC50: 145 nM
PDE1B, IC50: 354 nM
PDE2A, IC50: 5130 nM
PDE3A, IC50: >10000 nM
PDE4B2, IC50: 619 nM
PDE4D2, IC50: 948 nM
PDE5A1, IC50: 1810 nM
   
PDE9A2, IC50: >10000 nM
PDE10A, IC50: 1310 nM
       
PDE4-IN-10      
PDE4B, IC50: 7.01 ± 1.0 μM
                 
ATX inhibitor 22                        
Autotaxin, IC50: 218 nM
MEY-003                        
Autotaxin
Irsogladine maleate      
PDE4
                 
Olprinone
PDE1, IC50: 150 μM
PDE2, IC50: 100 μM
PDE3, IC50: 0.35 μM
PDE4, IC50: 14 μM
                  99.29%