PDE4

PDE4 Related Products (67):

By Type:	Pan (38) Selective (24)

Cat. No.	Product Name	Effect	Purity

HY-15455

Roflumilast	Inhibitor	99.87%
Roflumilast (APTA-2217) is a selective PDE4 inhibitor with IC₅₀s of 0.7, 0.9, 0.7, and 0.2 nM for PDE4A1, PDEA4, PDEB1, and PDEB2, respectively, without affecting PDE1, PDE2, PDE3 or PDE5 isoenzymes from various cells.

HY-12085

Apremilast	Inhibitor	99.87%
Apremilast (CC-10004) is an orally available inhibitor of type-4 cyclic nucleotide phosphodiesterase (PDE-4) with an IC₅₀ of 74 nM.

HY-N0014

Icariin	Inhibitor	99.06%
Icariin is a flavonol glycoside.

HY-117571

Zatolmilast	Inhibitor	98.98%
Zatolmilast (BPN14770) is a selective phosphodiesterase 4D (PDE4D) allosteric inhibitor with IC₅₀s of 7.8 nM and 7.4 nM for PDE4D7 and PDE4D3, respectively.

HY-16558

Butein	Inhibitor	99.92%
Butein is a cAMP-specific PDE inhibitor with an IC₅₀ of 10.4 μM for PDE4.

HY-116808B

TPN729MA	Inhibitor
TPN729MA (TPN729 maleate) is a selective phosphodiesterase type 5 (PDE5) inhibitor with an IC₅₀ value of 2.28 nM.

HY-116808

TPN729	Inhibitor
TPN729 is a selective phosphodiesterase type 5 (PDE5) inhibitor with an IC₅₀ value of 2.28 nM.

HY-N3180

Norbraylin	Inhibitor
Norbraylin, a natural prenylated coumarin, is a PDE4D2 inhibitor with an IC₅₀ value of 7.15 μM.

HY-122942

Moracin M	Inhibitor	98.90%
Moracin M, a phenolic component in the skin of Morus alba Linn.

HY-B0442A

Vardenafil hydrochloride	Inhibitor	99.48%
Vardenafil hydrochloride is a selective and orally active inhibitor of phosphodiesterase-5 (PDE5), with an IC₅₀ of 0.7 nM.

HY-100927

Ro 20-1724	Inhibitor	99.34%
Ro 20-1724 (Ro 20-174) is a potent inhibitor of cAMP-specific phosphodiesterase (PDE4/PDE IV) with a K_i of 1930 nM.

HY-10790

Cilomilast	Inhibitor	99.89%
Cilomilast (SB-207499) is a potent, selective and orally active inhibitor of Phosphodiesterase 4 (PDE4), with IC₅₀s of ~100 and 120 nM for LPDE4 and HPDE4, respectively.

HY-10469

GSK256066	Inhibitor	98.15%
GSK256066 is a selective and high-affinity phosphodiesterase 4 (PDE4) inhibitor, with an IC₅₀ of 3.2 pM for PDE4B.

HY-106003

GSK356278	Inhibitor	99.89%
GSK356278 is a potent, selective, orally bioavailable and brain-penetrant inhibitor of phosphodiesterase 4 (PDE4), with pIC₅₀s of 8.6, 8.8, and 8.7 for human PDE4A, PDE4B, and PDE4D, respectively.

HY-18252

Avanafil	Inhibitor	≥98.0%
Avanafil (TA-1790) is a potent and selective phosphodiesterase-5 (PDE-5) inhibitor with IC₅₀ values of 5.2 nM, 630 nM, 5700 nM, 6200 nM, 12000 nM, 27000 nM, 51000 nM and 53000 nM for PDE-5, PDE-6, PDE-4, PDE-10, PDE-8, PDE-7, PDE-2 and PDE-1, respectively.

HY-15485

Zardaverine	Inhibitor	98.73%
Zardaverine is an orally active and selective PDE3/4 inhibitor (IC₅₀)=0.58 uM/0.17 uM) with potent bronchodilator activity.

HY-101762

TyK2-IN-2	Inhibitor	98.64%
TyK2-IN-2 (Compoud 18) is a potent and selective TYK2 inhibitor with IC₅₀s of 7 nM, 0.1 μM and 0.05 μM for TYK2 JH2, IL-23 and IFNα, respectively.

HY-B0442

Vardenafil	Inhibitor	99.58%
Vardenafil is a selective and orally active inhibitor of phosphodiesterase-5 (PDE5), with an IC₅₀ of 0.7 nM.

HY-B1639

Enoximone	Inhibitor	98.05%
Enoximone is an inotropic vasodilating agent and a selective and orally active phosphodiesterase III (PDE3) inhibitor with an IC₅₀ of 5.9 μM.

HY-115687

PDE4B-IN-2	Inhibitor	99.21%
PDE4B-IN-2 is an orally active and selective PDE4B inhibitor with an IC₅₀ of 15 nM.

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