85416-73-5
85416-73-5
Chemical Structure
(S)-(+)-Rolipram
Synonym(s): (+)-Rolipram; (S)-Rolipram
- CAS. Nr.: 85416-73-5
- Formula:C16H21NO3
- Molecular Weight:275.34
IUPAC Name: (S)-4-(3-(cyclopentyloxy)-4-methoxyphenyl)pyrrolidin-2-one
InChIKey: HJORMJIFDVBMOB-GFCCVEGCSA-N
SMILES: O=C1NC[C@H](C2=CC=C(OC)C(OC3CCCC3)=C2)C1
Biological Activity: (S)-(+)-Rolipram ((+)-Rolipram) is a cyclic AMP(cAMP)-specific phosphodiesterase 4 (PDE4) inhibitor, with an IC50 of 1100 nM. (S)-(+)-Rolipram can suppresse tumor necrosis factor-alpha (TNFα) production by human mononuclear cells[1][2][3].
| Art. -Nr. | Produktname | Reinheit | Beschreibung | Pricing | |||||||||||||||||||
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(S)-(+)-Rolipram | 99.96% | (S)-(+)-Rolipram ((+)-Rolipram) is a cyclic AMP(cAMP)-specific phosphodiesterase 4 (PDE4) inhibitor, with an IC50 of 1100 nM. (S)-(+)-Rolipram can suppresse tumor necrosis factor-alpha (TNFα) production by human mononuclear cells. | ||||||||||||||||||||
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References
- [1]. Semmler J, et, al. The specific type IV phosphodiesterase inhibitor rolipram suppresses tumor necrosis factor-alpha production by human mononuclear cells. Int J Immunopharmacol. 1993 Apr;15(3):409-13. [Content Brief]
- [2]. Wachtel H. Neurotropic effects of the optical isomers of the selective adenosine cyclic 3',5'-monophosphate phosphodiesterase inhibitor rolipram in rats in-vivo. J Pharm Pharmacol. 1983 Jul;35(7):440-4. [Content Brief]
- [3]. Ortmann R, et, al. Rolipram forms a potent discriminative stimulus in drug discrimination experiments in rats. Psychopharmacology (Berl). 1986;89(3):273-7. [Content Brief]
