489-32-7
489-32-7
Chemical Structure
Icariin
Synonym(s): Ieariline
- CAS No.: 489-32-7
- Formula:C33H40O15
- Molecular Weight:676.66
IUPAC Name: 5-hydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-en-1-yl)-7-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-3-(((2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-4H-chromen-4-one
InChIKey: TZJALUIVHRYQQB-XLRXWWTNSA-N
SMILES: O[C@H]1[C@H](O)[C@@H](CO)O[C@@H](OC2=C(C/C=C(C)/C)C(OC(C3=CC=C(OC)C=C3)=C(O[C@@H]4O[C@@H](C)[C@H](O)[C@@H](O)[C@H]4O)C5=O)=C5C(O)=C2)[C@@H]1O
Biological Activity: Icariin is a flavonol glycoside. Icariin inhibits PDE5 and PDE4 activities with IC50s of 432 nM and 73.50 μM, respectively. Icariin also is a PPARα activator.
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Icariin | 98.95% | Icariin is a flavonol glycoside. Icariin inhibits PDE5 and PDE4 activities with IC50s of 432 nM and 73.50 μM, respectively. Icariin also is a PPARα activator. | ||||||||||||||||||||
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Icariin (Standard) | 97.21% | Icariin (Standard) is the analytical standard of Icariin. This product is intended for research and analytical applications. Icariin is a flavonol glycoside. Icariin inhibits PDE5 and PDE4 activities with IC50s of 432 nM and 73.50 μM, respectively. Icariin also is a PPARα activator. | ||||||||||||||||||||
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Maohuoside B | Maohuoside B is a flavonoid, that can be isolated from Epimedium koreanum Nakai. | |||||||||||||||||||||
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Epimedin A1 | 99.96% | Epimedin A1 is a flavonoid extracted from Herba Epimedii which is one of commonly used Chinese medicines. | ||||||||||||||||||||
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Epimedin B (Standard) | ≥98% | Epimedin B (Standard) (Epmedin B (Standard)) is the analytical standard of Epimedin B (HY-N0259). This product is intended for research and analytical applications. Epimedin B (Epmedin B) is a flavonoid active component found in Epimedium, with oral activity, and exhibits anti-osteoporotic and neuroprotective effects. Epimedin B inhibits RANKL-induced osteoclast differentiation, F-actin ring formation, and mature osteoclast bone resorption, inhibits the phosphorylation of JNK, p38 MAPK, PI3K, and AKT, activates the AMPK-Nrf2 antioxidant pathway, and reduces cellular and mitochondrial ROS. Epimedin B acts on ESR1 and exerts its effects via GPER. Epimedin B alleviates bone loss and improves bone microstructure in vivo, and in Parkinson's models protects dopaminergic neurons and maintains striatal dopamine levels through anti-apoptotic and anti-endoplasmic reticulum stress effects. Epimedin B can be used for research related to osteoporosis, diabetic osteoporosis, and Parkinson's disease. | ||||||||||||||||||||
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Epmedin C | 99.69% | Epmedin C (Epimedin-C; Baohuoside-VI) is an orally active anti-inflammatory agent and immunomodulator that binds to multiple key proteins including UCP1, Caspase-1, CDK2 and Keap1. Epmedin C inhibits epithelial cell proliferation by disrupting the complex function of CDK2/Cyclin E. Epmedin C also upregulates Nrf2 expression, reduces ROS levels and inhibits pro-inflammatory cytokine secretion, thereby effectively restoring antibody production and alleviating tissue damage. Epmedin C has good safety with no hepatotoxicity or skin sensitization, and it has been used in studies on diseases such as obesity, Deoxynivalenol (HY-N6684)-induced immunotoxicity and mammary hyperplasia. | ||||||||||||||||||||
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Sagittatoside A | 99.47% | Sagittatoside A (Icariin-A) is a natural compound extracted from the plant Epimedium. | ||||||||||||||||||||
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Iso-Sagittatoside A | Iso-Sagittatoside A is the metabolite of effective Erxian Decoction (EXD, a Chinese medicine prescription for menopausal syndromes) in rat plasma. | |||||||||||||||||||||
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Sagittasine C | Sagittasine C is a flavonol glycoside found in the aerial parts of Epimedium pubescens MAXIM. | |||||||||||||||||||||
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Baohuoside VII | Baohuoside VII is a flavonoid isolated from Herba Epimedii, with anti-osteoporosis activities. | |||||||||||||||||||||
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Epimedoside A | 99.87% | Epimedoside A is a flavonoid isolated from the roots of Epimedium wushanense. Epimedoside A exhibits significant antioxidant activity in vitro. | ||||||||||||||||||||
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Epimedin B1 | Epimedin B1 is initially isolated from E. Wushanense and is a Chemical marker of E. sagittatum in agent Yin-Yang-Huo. Epimedin B1 is the isomer of Epimedin B. | |||||||||||||||||||||
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