1. Metabolic Enzyme/Protease
  2. Phosphodiesterase (PDE)
  3. Vardenafil

Vardenafil 

Cat. No.: HY-B0442
Handling Instructions

Vardenafil is a selective, orally active, potent inhibitor of phosphodiesterase-5 (PDE5), with an IC50 of 0.7 nM. Vardenafil shows selectivity over PDE1 (180 nM), PDE6 (11 nM), PDE2, PDE3, and PDE4 (>1000 nM). Vardenafil competitively inhibits cyclic guanosine monophosphate (cGMP) hydrolysis and thus increases cGMP levels. Vardenafil can be used for the research of erectile dysfunction.

For research use only. We do not sell to patients.

Vardenafil Chemical Structure

Vardenafil Chemical Structure

CAS No. : 224785-90-4

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Description

Vardenafil is a selective, orally active, potent inhibitor of phosphodiesterase-5 (PDE5), with an IC50 of 0.7 nM. Vardenafil shows selectivity over PDE1 (180 nM), PDE6 (11 nM), PDE2, PDE3, and PDE4 (>1000 nM). Vardenafil competitively inhibits cyclic guanosine monophosphate (cGMP) hydrolysis and thus increases cGMP levels. Vardenafil can be used for the research of erectile dysfunction[1][2].

IC50 & Target[2]

PDE5

0.7 nM (IC50)

PDE6

11 nM (IC50)

PDE1

180 nM (IC50)

In Vitro

Vardenafil specifically inhibits the hydrolysis of cGMP by PDE5 with an IC50 of 0.7 nM[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

488.60

Formula

C₂₃H₃₂N₆O₄S

CAS No.

224785-90-4

SMILES

CCCC1=NC(C)=C2N1N=C(C(C=C(S(=O)(N3CCN(CC)CC3)=O)C=C4)=C4OCC)NC2=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

VardenafilPhosphodiesterase (PDE)cGMPselectivesmoothmuscleNOstimulationerectiledysfunctionInhibitorinhibitorinhibit

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