1. Metabolic Enzyme/Protease Apoptosis
  2. Phosphodiesterase (PDE) Apoptosis
  3. Dipyridamole

Dipyridamole 

Cat. No.: HY-B0312 Purity: 99.61%
COA Handling Instructions

Dipyridamole is an orally active phosphodiesterase (PDE) inhibitor. Dipyridamole also is an antiplatelet agent used in secondary prophylaxis against stroke. Dipyridamole can induce cancer cell-specific apoptosis.

For research use only. We do not sell to patients.

Dipyridamole Chemical Structure

Dipyridamole Chemical Structure

CAS No. : 58-32-2

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10 mM * 1 mL in DMSO
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500 mg USD 86 In-stock
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Based on 2 publication(s) in Google Scholar

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Description

Dipyridamole is an orally active phosphodiesterase (PDE) inhibitor. Dipyridamole also is an antiplatelet agent used in secondary prophylaxis against stroke. Dipyridamole can induce cancer cell-specific apoptosis[1][2][3].

IC50 & Target

PDE

In Vitro

Dipyridamole (5 μM; 15 min) results in a 2.5-fold increase in intracellular cAMP levels in OCI-AML-3 cells[2].
? Dipyridamole (5 μM; 48 h) with the statin combination induces apoptosis in primary AML cells[2].
? Dipyridamole (5 μM; 48 h) possesse cAMP/PKA-independent activity against statininduced SREBP2 activation[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis[2]

Cell Line: AML (OCI-AML-2, OCI-AML-3) cell line
Concentration: 5 μM
Incubation Time: 48 h
Result: Induced apoptosis with the combination of fluvastatin and dipyridamole, cilostazol, forskolin, or dbcAMP in OCI-AML-2 and OCI-AML-3 cells.

RT-PCR[2]

Cell Line: LP1 cell line
Concentration: 5 μM
Incubation Time: 16 h
Result: Increased the sensibility of cancer cells to statin-induced apoptosis.
In Vivo

Dipyridamole (10 mg/kg; p.o. once daily for 18 d) mitigates tumor growth, ameliorated concurrent alterations in blood circulation and tumor tissues, and platelet infiltration in tumor tissues[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6-LLC tumor-bearing mice models[3]
Dosage: 10 mg/kg
Administration: Oral gavage; 10 mg/kg; once daily for 18 days
Result: Mitigated tumor growth in tumor-bearing mice.
Clinical Trial
Molecular Weight

504.63

Formula

C24H40N8O4

CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

OCCN(CCO)C1=NC(N2CCCCC2)=C(N=C(N(CCO)CCO)N=C3N4CCCCC4)C3=N1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 1 years; -20°C, 6 months (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 50 mg/mL (99.08 mM)

H2O : 0.67 mg/mL (1.33 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9816 mL 9.9082 mL 19.8165 mL
5 mM 0.3963 mL 1.9816 mL 3.9633 mL
10 mM 0.1982 mL 0.9908 mL 1.9816 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (4.95 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (4.95 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (4.95 mM); Clear solution

*All of the co-solvents are available by MedChemExpress (MCE).
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Dipyridamole
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