1. Metabolic Enzyme/Protease
  2. Phosphodiesterase (PDE)

Dipyridamole 

Cat. No.: HY-B0312 Purity: 98.02%
Handling Instructions

Dipyridamole (Persantine) is a phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells.

For research use only. We do not sell to patients.

Dipyridamole Chemical Structure

Dipyridamole Chemical Structure

CAS No. : 58-32-2

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 66 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
100 mg USD 60 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
500 mg USD 78 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
1 g   Get quote  
5 g   Get quote  

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  • Biological Activity

  • Technical Information

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  • References

Description

Dipyridamole (Persantine) is a phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Target: Phosphodiesterase (PDE) Dipyridamole concentrations of 1 nmol/ml blood caused 90% inhibition of adenosine metabolism. Dipyridamole at therapeutic concentrations causes significant inhibition of adenosine metabolism in whole blood [1]. Dipyridamole has a dose-dependent inhibitory effect on thromboxane synthesis which was independent of aggregation. Dipyridamole also inhibited malonyldialdehyde production in response to both thrombin and arachidonic acid [2]. Dipyridamole enhances platelet inhibition by amplifying the signaling of the NO donor sodium nitroprusside. These data support the concept that enhancement of endothelium-dependent NO/cGMP-mediated signaling may be an important in vivo component of dipyridamole action [3].

Clinical Trial
Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9816 mL 9.9082 mL 19.8165 mL
5 mM 0.3963 mL 1.9816 mL 3.9633 mL
10 mM 0.1982 mL 0.9908 mL 1.9816 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

504.63

Formula

C₂₄H₄₀N₈O₄

CAS No.

58-32-2

SMILES

OCCN(CCO)C1=NC(N2CCCCC2)=C(N=C(N(CCO)CCO)N=C3N4CCCCC4)C3=N1

Storage

4°C, protect from light

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
Dipyridamole
Cat. No.:
HY-B0312
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Dipyridamole

Cat. No.: HY-B0312