1. Metabolic Enzyme/Protease
  2. Phosphodiesterase (PDE)
  3. Vardenafil hydrochloride

Vardenafil hydrochloride 

Cat. No.: HY-B0442A Purity: 99.51%
Handling Instructions

Vardenafil hydrochloride is a selective, orally active, potent inhibitor of phosphodiesterase-5 (PDE5), with an IC50 of 0.7 nM. Vardenafil hydrochloride shows selectivity over PDE1 (180 nM), PDE6 (11 nM), PDE2, PDE3, and PDE4 (>1000 nM). Vardenafil hydrochloride competitively inhibits cyclic guanosine monophosphate (cGMP) hydrolysis and thus increases cGMP levels. Vardenafil hydrochloride can be used for the research of erectile dysfunction.

For research use only. We do not sell to patients.

Vardenafil hydrochloride Chemical Structure

Vardenafil hydrochloride Chemical Structure

CAS No. : 224785-91-5

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10 mM * 1 mL in DMSO USD 92 In-stock
Estimated Time of Arrival: December 31
100 mg USD 84 In-stock
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200 mg USD 151 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Vardenafil hydrochloride is a selective, orally active, potent inhibitor of phosphodiesterase-5 (PDE5), with an IC50 of 0.7 nM. Vardenafil hydrochloride shows selectivity over PDE1 (180 nM), PDE6 (11 nM), PDE2, PDE3, and PDE4 (>1000 nM). Vardenafil hydrochloride competitively inhibits cyclic guanosine monophosphate (cGMP) hydrolysis and thus increases cGMP levels. Vardenafil hydrochloride can be used for the research of erectile dysfunction[1][2].

IC50 & Target[2]

PDE5

0.7 nM (IC50)

PDE6

11 nM (IC50)

PDE1

180 nM (IC50)

In Vitro

Vardenafil specifically inhibits the hydrolysis of cGMP by PDE5 with an IC50 of 0.7 nM[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

525.06

Formula

C₂₃H₃₃ClN₆O₄S

CAS No.

224785-91-5

SMILES

CCCC1=NC(C)=C2N1N=C(C(C=C(S(=O)(N3CCN(CC)CC3)=O)C=C4)=C4OCC)NC2=O.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (190.45 mM; Need ultrasonic)

H2O : ≥ 100 mg/mL (190.45 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9045 mL 9.5227 mL 19.0454 mL
5 mM 0.3809 mL 1.9045 mL 3.8091 mL
10 mM 0.1905 mL 0.9523 mL 1.9045 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (4.76 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (4.76 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (4.76 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

VardenafilPhosphodiesterase (PDE)cGMPselectivesmoothmuscleNOstimulationerectiledysfunctionInhibitorinhibitorinhibit

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Product Name:
Vardenafil hydrochloride
Cat. No.:
HY-B0442A
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