2. Metabolic Enzyme/Protease
  3. Phosphodiesterase (PDE)
  4. Ro 20-1724

Ro 20-1724  (Synonyms: Ro 20-174)

Cat. No.: HY-100927 Purity: 99.34%
COA Handling Instructions

Ro 20-1724 (Ro 20-174) is a potent inhibitor of cAMP-specific phosphodiesterase (PDE4/PDE IV) with a Ki of 1930 nM. Neuroprotective effect.

For research use only. We do not sell to patients.

Ro 20-1724 Chemical Structure

Ro 20-1724 Chemical Structure

CAS No. : 29925-17-5

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25 mg USD 160 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Ro 20-1724 (Ro 20-174) is a potent inhibitor of cAMP-specific phosphodiesterase (PDE4/PDE IV) with a Ki of 1930 nM. Neuroprotective effect[1][2].

IC50 & Target[1]

PDE4

1930 nM (Ki)

In Vivo

Ro 20-1724 (125, 250 and 500 μg/kg; i.p.; 21 days following first i.c.v. streptozotocin administration; 200-250 g adult (3-5 months old) male albino Wistar rats) significantly attenuated streptozotocin induced cognitive deficit and oxidative stress[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

278.35

Appearance

Solid

Formula

C15H22N2O3
CAS No.
SMILES

O=C1NC(CC2=CC=C(OC)C(OCCCC)=C2)CN1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
In Vitro: 

DMSO : ≥ 50 mg/mL (179.63 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5926 mL 17.9630 mL 35.9260 mL
5 mM 0.7185 mL 3.5926 mL 7.1852 mL
10 mM 0.3593 mL 1.7963 mL 3.5926 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (8.98 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (8.98 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (8.98 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 99.34%

COA (245 KB) HNMR (270 KB) LCMS (255 KB)

Handling Instructions (2659 KB)
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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This equation is commonly abbreviated as: C1V1 = C2V2

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Keywords:

Ro 20-172429925-17-5Ro 20-174Phosphodiesterase (PDE)cAMPphosphodiesteraseantioxidantneuroprotectivecognitiveInhibitorinhibitorinhibit

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