29925-17-5
29925-17-5
Chemical Structure
Ro 20-1724
Synonym(s): Ro 20-174
- CAS No.: 29925-17-5
- Formula:C15H22N2O3
- Molecular Weight:278.35
IUPAC Name: 4-(3-butoxy-4-methoxybenzyl)imidazolidin-2-one
InChIKey: PDMUULPVBYQBBK-UHFFFAOYSA-N
SMILES: O=C1NC(CC2=CC=C(OC)C(OCCCC)=C2)CN1
Biological Activity: Ro 20-1724 (Ro 20-174) is a potent inhibitor of cAMP-specific phosphodiesterase (PDE4/PDE IV) with a Ki of 1930 nM. Neuroprotective effect[1][2].
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Ro 20-1724 | 99.98% | Ro 20-1724 (Ro 20-174) is a potent inhibitor of cAMP-specific phosphodiesterase (PDE4/PDE IV) with a Ki of 1930 nM. Neuroprotective effect. | ||||||||||||||||||||
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Ro 20-1724 (Standard) | ≥98% | Ro 20-1724 (Standard) is the analytical standard of Ro 20-1724. This product is intended for research and analytical applications. Ro 20-1724 (Ro 20-174) is a potent inhibitor of cAMP-specific phosphodiesterase (PDE4/PDE IV) with a Ki of 1930 nM. Neuroprotective effect. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.78
HY-123176GYKI-13380 -
Similarity Score 0.63
HY-170741N-Ethyl-3,4-DMA hydrochloride -
Similarity Score 0.62
HY-W102476R1-(4-(3-Chloropropoxy)-3-methoxyphenyl)ethanone (Standard) -
Similarity Score 0.62
HY-1720593C-P hydrochloride -
Similarity Score 0.62
HY-1155823,4-DMMA hydrochloride -
Similarity Score 0.61
HY-N9947Methyl-6-gingerol -
Similarity Score 0.61
HY-N9947A(rac)-Methyl-6-gingerol -
Similarity Score 0.61
HY-170742N,N-Dimethyl-3,4-DMA hydrochloride -
Similarity Score 0.61
HY-W008157R(S)-2-Amino-3-(3,4-dimethoxyphenyl)propionic acid (Standard) -
Explore the MedChemAI to find more analogs
References
- [1]. Brackeen MF, et al. Design and synthesis of conformationally constrained analogues of 4-(3-butoxy-4-methoxybenzyl)imidazolidin-2-one (Ro 20-1724) as potent inhibitors of cAMP-specific phosphodiesterase. J Med Chem. 1995;38(24):4848-4854. [Content Brief]
- [2]. Sharma V, et al. Neuroprotective effect of RO-20-1724-a phosphodiesterase4 inhibitor against intracerebroventricular streptozotocin induced cognitive deficit and oxidative stress in rats. Pharmacol Biochem Behav. 2012;101(2):239-245. [Content Brief]
