1. Metabolic Enzyme/Protease
  2. Phosphodiesterase (PDE)
  3. PDE4B-IN-2

PDE4B-IN-2 

Cat. No.: HY-115687
Handling Instructions

PDE4B-IN-2 is an orally active and selective PDE4B inhibitor (IC50=15 nM) and exhibits >100-fold selectivity for PDE4B over 4D. PDE4B-IN-2 regulates cAMP in inflammatory cells and inhibits LPS-induced TNF-α production and neutrophil accumulation in mouse lungs. PDE4B-IN-2 reduces microglial and neutrophil activation, and improves behavioral deficits in a traumatic brain injury model in vivo. PDE4B-IN-2 also exhibits antidepressant-like effects.

For research use only. We do not sell to patients.

PDE4B-IN-2 Chemical Structure

PDE4B-IN-2 Chemical Structure

CAS No. : 915082-52-9

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Description

PDE4B-IN-2 is an orally active and selective PDE4B inhibitor (IC50=15 nM) and exhibits >100-fold selectivity for PDE4B over 4D. PDE4B-IN-2 regulates cAMP in inflammatory cells and inhibits LPS-induced TNF-α production and neutrophil accumulation in mouse lungs. PDE4B-IN-2 reduces microglial and neutrophil activation, and improves behavioral deficits in a traumatic brain injury model in vivo. PDE4B-IN-2 also exhibits antidepressant-like effects.

Molecular Weight

387.88

Formula

C₁₉H₁₈ClN₃O₂S

CAS No.

915082-52-9

SMILES

O=C(O)CC1=CC=C(NC2=NC(C3=CC=C(Cl)S3)=NC(C)=C2CC)C=C1

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Keywords:

PDE4B-IN-2Phosphodiesterase (PDE)Inhibitorinhibitorinhibit

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PDE4B-IN-2
Cat. No.:
HY-115687
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