2374703-19-0
2374703-19-0
Chemical Structure
MR-L2
- CAS No.: 2374703-19-0
- Formula:C19H16Cl3FN4O
- Molecular Weight:441.71
IUPAC Name: 2-(3-(4-chloro-3-fluorophenyl)-5-ethyl-1H-1,2,4-triazol-1-yl)-N-(3,5-dichlorobenzyl)acetamide
InChIKey: JXACCOKEEPXHCF-UHFFFAOYSA-N
SMILES: ClC1=C(F)C=C(C2=NN(CC(NCC3=CC(Cl)=CC(Cl)=C3)=O)C(CC)=N2)C=C1
Biological Activity: MR-L2 is a reversible and noncompetitive allosteric activator of long-isoform phosphodiesterase-4 (PDE4), activates representative PDE4 long-isoform variants (PDE4A4, PDE4B1, PDE4C3, PDE4D5). MR-L2 suppresses PGE2-induced MDCK cell cyst formation with an EC50 of 1.2 μM[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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MR-L2 | 98.37% | MR-L2 is a reversible and noncompetitive allosteric activator of long-isoform phosphodiesterase-4 (PDE4), activates representative PDE4 long-isoform variants (PDE4A4, PDE4B1, PDE4C3, PDE4D5). MR-L2 suppresses PGE2-induced MDCK cell cyst formation with an EC50 of 1.2 μM. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.46
HY-121827LH21 -
Similarity Score 0.45
HY-157530VAP-1-IN-3 -
Similarity Score 0.44
HY-149662TMDJ-035 -
Similarity Score 0.44
HY-101145CK37 -
Similarity Score 0.44
HY-149935OICR-8268 -
Similarity Score 0.44
HY-120496Clofutriben -
Similarity Score 0.44
HY-W808862Ethyl 2-(3,5-di(pyridin-4-yl)-1H-1,2,4-triazol-1-yl)acetate -
Similarity Score 0.43
HY-19337Ketodarolutamide -
Similarity Score 0.43
HY-118037VUF10132 -
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