2374703-19-0

MR-L2 Chemical Structure
2374703-19-0

Chemical Structure

MR-L2

  • CAS No.: 2374703-19-0
  • Formula:C19H16Cl3FN4O
  • Molecular Weight:441.71

IUPAC Name: 2-(3-(4-chloro-3-fluorophenyl)-5-ethyl-1H-1,2,4-triazol-1-yl)-N-(3,5-dichlorobenzyl)acetamide

InChIKey: JXACCOKEEPXHCF-UHFFFAOYSA-N

SMILES: ClC1=C(F)C=C(C2=NN(CC(NCC3=CC(Cl)=CC(Cl)=C3)=O)C(CC)=N2)C=C1

Biological Activity: MR-L2 is a reversible and noncompetitive allosteric activator of long-isoform phosphodiesterase-4 (PDE4), activates representative PDE4 long-isoform variants (PDE4A4, PDE4B1, PDE4C3, PDE4D5). MR-L2 suppresses PGE2-induced MDCK cell cyst formation with an EC50 of 1.2 μM[1].

Cat. No. Product Name Purity Description Pricing
HY-128358 		MR-L2 98.37% MR-L2 is a reversible and noncompetitive allosteric activator of long-isoform phosphodiesterase-4 (PDE4), activates representative PDE4 long-isoform variants (PDE4A4, PDE4B1, PDE4C3, PDE4D5). MR-L2 suppresses PGE2-induced MDCK cell cyst formation with an EC50 of 1.2 μM.
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