1. Metabolic Enzyme/Protease
  2. Phosphodiesterase (PDE)
  3. MR-L2

MR-L2 

Cat. No.: HY-128358 Purity: 99.36%
COA Handling Instructions

MR-L2 is a reversible and noncompetitive allosteric activator of long-isoform phosphodiesterase-4 (PDE4), activates representative PDE4 long-isoform variants (PDE4A4, PDE4B1, PDE4C3, PDE4D5). MR-L2 suppresses PGE2-induced MDCK cell cyst formation with an EC50 of 1.2 µM.

For research use only. We do not sell to patients.

MR-L2 Chemical Structure

MR-L2 Chemical Structure

CAS No. : 2374703-19-0

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 495 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 495 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 450 In-stock
Estimated Time of Arrival: December 31
10 mg USD 750 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2250 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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  • Biological Activity

  • Purity & Documentation

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Description

MR-L2 is a reversible and noncompetitive allosteric activator of long-isoform phosphodiesterase-4 (PDE4), activates representative PDE4 long-isoform variants (PDE4A4, PDE4B1, PDE4C3, PDE4D5). MR-L2 suppresses PGE2-induced MDCK cell cyst formation with an EC50 of 1.2 µM[1].

IC50 & Target

PDE4[1]

In Vitro

MR-L2 (0.3-10 μM; 1 h) significantly suppresses cAMP elevation and cysts formation in MDCK cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: Madin-Darby Canine Kidney (MDCK) cell line
Concentration: 0.3, 1, 3 and 10 μM
Incubation Time: 1 hour
Result: Suppressed cAMP elevation but not enhanced cAMP excretion in MDCK cells. Suppressed cysts formation in MDCK cells with an EC50 value of 1.2 µM. Suppressed the number of cysts formation in 3D culture for both unstimulated and vasopressin-treated culture condition while showed no effect on cell viability.
Molecular Weight

441.71

Formula

C19H16Cl3FN4O

CAS No.
SMILES

ClC1=C(F)C=C(C2=NN(CC(NCC3=CC(Cl)=CC(Cl)=C3)=O)C(CC)=N2)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 83.33 mg/mL (188.65 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2639 mL 11.3196 mL 22.6393 mL
5 mM 0.4528 mL 2.2639 mL 4.5279 mL
10 mM 0.2264 mL 1.1320 mL 2.2639 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.71 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 99.36%

References
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MR-L2
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HY-128358
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