1. Metabolic Enzyme/Protease
  2. Phosphodiesterase (PDE)
  3. D159687

D159687 

Cat. No.: HY-15444 Purity: 98.00%
Handling Instructions

D159687 is a selective PDE4D inhibitor.

For research use only. We do not sell to patients.

D159687 Chemical Structure

D159687 Chemical Structure

CAS No. : 1155877-97-6

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 495 In-stock
Estimated Time of Arrival: December 31
5 mg USD 450 In-stock
Estimated Time of Arrival: December 31
10 mg USD 750 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2250 In-stock
Estimated Time of Arrival: December 31
100 mg USD 3300 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products
  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

D159687 is a selective PDE4D inhibitor[1].

IC50 & Target

PDE4D[1]

In Vitro

D159687 (1 μM, 0-24 hours) induces a transient increase in CREB phosphorylation which peaked at 6 hours after treatment[1].
D159687 (0.01-1 μM, 6 hours) causes optimal CREB phosphorylation at 1 μM[1].

Western Blot Analysis[1]

Cell Line: HT-22 (mouse hippocampal cell line)
Concentration: 1 μM
Incubation Time: 0, 1, 3, 6, 12, 24 hours
Result: Induced a transient increase in CREB phosphorylation which peaked at 6 hours after treatment.

Western Blot Analysis[1]

Cell Line: HT-22 (mouse hippocampal cell line)
Concentration: 0.01 μM, 0.1 μM, 1 μM
Incubation Time: 6 hours
Result: CREB phosphorylation was optimal at 1 μM.
In Vivo

D159687 (0.05-5 mg/kg; oral daily for a week) shows a potential recruitment or enhancement of synaptic function with increased task difficulty in female Cynomolgus macaques[2].

Animal Model: Female Cynomolgus macaques (4–6 year old) [2]
Dosage: 0.05, 0.5, 5 mg/kg
Administration: Oral daily for a week
Result: A potential recruitment or enhancement of synaptic function with increased task difficulty.
Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 150 mg/mL (408.90 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7260 mL 13.6299 mL 27.2598 mL
5 mM 0.5452 mL 2.7260 mL 5.4520 mL
10 mM 0.2726 mL 1.3630 mL 2.7260 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (6.81 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (6.81 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (6.81 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Molecular Weight

366.84

Formula

C₂₁H₁₉ClN₂O₂

CAS No.

1155877-97-6

SMILES

NC(NC1=CC=C(CC2=CC(C3=CC(Cl)=CC=C3)=C(OC)C=C2)C=C1)=O

Shipping

Room temperature in continental US; may vary elsewhere

Purity: 98.00%

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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2

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Product Name:
D159687
Cat. No.:
HY-15444
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D159687

Cat. No.: HY-15444