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  3. PI4KIIIbeta-IN-9

PI4KIIIbeta-IN-9 

Cat. No.: HY-19798 Purity: 99.01%
Handling Instructions

PI4KIIIbeta-IN-9 is a potent PI4KIIIβ inhibitor with an IC50 of 7 nM. PI4KIIIbeta-IN-9 also inhibits PI3Kδ and PI3Kγ with IC50s of 152 nM and 1046 nM, respectively.

For research use only. We do not sell to patients.

PI4KIIIbeta-IN-9 Chemical Structure

PI4KIIIbeta-IN-9 Chemical Structure

CAS No. : 1429624-84-9

Size Price Stock Quantity
1 mg USD 110 In-stock
Estimated Time of Arrival: December 31
5 mg USD 300 In-stock
Estimated Time of Arrival: December 31
10 mg USD 450 In-stock
Estimated Time of Arrival: December 31
25 mg USD 980 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1750 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

PI4KIIIbeta-IN-9 is a potent PI4KIIIβ inhibitor with an IC50 of 7 nM. PI4KIIIbeta-IN-9 also inhibits PI3Kδ and PI3Kγ with IC50s of 152 nM and 1046 nM, respectively.

IC50 & Target[1]

PI4KIIIβ

7 nM (IC50)

PI4KIIIα

2.6 μM (IC50)

PI3Kδ

152 nM (IC50)

PI3Kγ

1046 nM (IC50)

PI3Kα

2 μM (IC50)

PI3KC2γ

1 μM (IC50)

In Vitro

PI4KIIIbeta-IN-9 (Compound 9) shows weak inhibition of PI3KC2γ (IC50 ~1 µM), PI3Kα (~2 µM), and PI4KIIIα (~2.6 µM) and <50% inhibition at concentrations up to 20 µM for PI4K2α, PI4K2β, and PI3Kβ. PI4KIIIbeta-IN-9 (Compound 9) forms a crescent shape that conforms to the active site of PI4KIIIβ. This molecule makes extensive contacts with PI4KIIIβ[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

487.59

Formula

C₂₃H₂₅N₃O₅S₂

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (205.09 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0509 mL 10.2545 mL 20.5090 mL
5 mM 0.4102 mL 2.0509 mL 4.1018 mL
10 mM 0.2051 mL 1.0255 mL 2.0509 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (5.13 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (5.13 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (5.13 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product Name:
PI4KIIIbeta-IN-9
Cat. No.:
HY-19798
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