1. PI3K/Akt/mTOR
  2. PI4K
    PI3K

PI4KIIIbeta-IN-9 

Cat. No.: HY-19798 Purity: 98.16%
Handling Instructions

PI4KIIIbeta-IN-9 is a potent PI4KIIIβ inhibitor with an IC50 of 7 nM. PI4KIIIbeta-IN-9 also inhibits PI3Kδ and PI3Kγ with IC50s of 152 nM and 1046 nM, respectively.

For research use only. We do not sell to patients.
PI4KIIIbeta-IN-9 Chemical Structure

PI4KIIIbeta-IN-9 Chemical Structure

CAS No. : 1429624-84-9

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 579 In-stock
1 mg USD 180 In-stock
5 mg USD 540 In-stock
10 mg USD 780 In-stock
25 mg USD 1560 In-stock
50 mg USD 2520 In-stock
100 mg   Get quote  
200 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

PI4KIIIbeta-IN-9 is a potent PI4KIIIβ inhibitor with an IC50 of 7 nM. PI4KIIIbeta-IN-9 also inhibits PI3Kδ and PI3Kγ with IC50s of 152 nM and 1046 nM, respectively.

IC50 & Target

IC50: 7 nM (PI4KIIIβ), 152 nM (PI3Kδ), 1046 nM (PI3Kγ), ~1 µM (PI3KC2γ), ~2 µM (PI3Kα), ~2.6 µM (PI4KIIIα), >20 μM (PI3Kβ), >20 μM (VPS34), >20 μM (PI4K2α), >20 μM (PI4K2β)[1]

In Vitro

PI4KIIIbeta-IN-9 (Compound 9) shows weak inhibition of PI3KC2γ (IC50 ~1 µM), PI3Kα (~2 µM), and PI4KIIIα (~2.6 µM) and <50% inhibition at concentrations up to 20 µM for PI4K2α, PI4K2β, and PI3Kβ. PI4KIIIbeta-IN-9 (Compound 9) forms a crescent shape that conforms to the active site of PI4KIIIβ. This molecule makes extensive contacts with PI4KIIIβ[1].

References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 2.0509 mL 10.2545 mL 20.5090 mL
5 mM 0.4102 mL 2.0509 mL 4.1018 mL
10 mM 0.2051 mL 1.0255 mL 2.0509 mL
Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

487.59

Formula

C₂₃H₂₅N₃O₅S₂

CAS No.

1429624-84-9

SMILES

CC(N=C1NC(C2CCCC2)=O)=C(S1)C3=CC=C(C(S(=O)(NC4=CC=C(O)C=C4)=O)=C3)OC

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
PI4KIIIbeta-IN-9
Cat. No.:
HY-19798
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