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  3. PI4KIIIbeta-IN-9

PI4KIIIbeta-IN-9 

Cat. No.: HY-19798 Purity: 98.16%
Handling Instructions

PI4KIIIbeta-IN-9 is a potent PI4KIIIβ inhibitor with an IC50 of 7 nM. PI4KIIIbeta-IN-9 also inhibits PI3Kδ and PI3Kγ with IC50s of 152 nM and 1046 nM, respectively.

For research use only. We do not sell to patients.

PI4KIIIbeta-IN-9 Chemical Structure

PI4KIIIbeta-IN-9 Chemical Structure

CAS No. : 1429624-84-9

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 322 In-stock
Estimated Time of Arrival: December 31
1 mg USD 110 In-stock
Estimated Time of Arrival: December 31
5 mg USD 300 In-stock
Estimated Time of Arrival: December 31
10 mg USD 450 In-stock
Estimated Time of Arrival: December 31
25 mg USD 980 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1750 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

PI4KIIIbeta-IN-9 is a potent PI4KIIIβ inhibitor with an IC50 of 7 nM. PI4KIIIbeta-IN-9 also inhibits PI3Kδ and PI3Kγ with IC50s of 152 nM and 1046 nM, respectively.

IC50 & Target[1]

PI4KIIIβ

7 nM (IC50)

PI4KIIIα

2.6 μM (IC50)

PI3Kδ

152 nM (IC50)

PI3Kγ

1046 nM (IC50)

PI3Kα

2 μM (IC50)

PI3KC2γ

1 μM (IC50)

In Vitro

PI4KIIIbeta-IN-9 (Compound 9) shows weak inhibition of PI3KC2γ (IC50 ~1 µM), PI3Kα (~2 µM), and PI4KIIIα (~2.6 µM) and <50% inhibition at concentrations up to 20 µM for PI4K2α, PI4K2β, and PI3Kβ. PI4KIIIbeta-IN-9 (Compound 9) forms a crescent shape that conforms to the active site of PI4KIIIβ. This molecule makes extensive contacts with PI4KIIIβ[1].

Molecular Weight

487.59

Formula

C₂₃H₂₅N₃O₅S₂

CAS No.

1429624-84-9

SMILES

CC(N=C1NC(C2CCCC2)=O)=C(S1)C3=CC=C(C(S(=O)(NC4=CC=C(O)C=C4)=O)=C3)OC

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
References
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PI4KIIIbeta-IN-9
Cat. No.:
HY-19798
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