1. Epigenetics
    Stem Cell/Wnt
    JAK/STAT Signaling
  2. JAK

Tyk2-IN-3 

Cat. No.: HY-18709
Handling Instructions

Tyk2-IN-3 is a Tyk2 pseudokinase inhibitor, with an IC50 of 485 nM.

For research use only. We do not sell to patients.

Tyk2-IN-3 Chemical Structure

Tyk2-IN-3 Chemical Structure

CAS No. : 1779493-12-7

Size Stock
250 mg Get quote
500 mg Get quote

* Please select Quantity before adding items.

View All JAK Isoform Specific Products:

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

Tyk2-IN-3 is a Tyk2 pseudokinase inhibitor, with an IC50 of 485 nM.

IC50 & Target

IC50: 485 nM (Tyk2)[1].

In Vivo

Tyk2-IN-3 (compound 1) is very potent against the Tyk2 pseudokinase (99% inhibition at 1 μM) but lacks potency against all other kinases in the kinome assay panel except IKK (96% inhibition) and the JAK1 pseudokinase domain (99% inhibition at 1 μM). No evidence of binding to the catalytic domain of Tyk2 or any other JAK family kinase is evident at 1 μM, and subsequent enzymatic assays confirm the lack of activity against purified catalytic domains (IC50>>2 μM). The pseudokinase domains of JAK2 and JAK3 are not part of the kinome screening panel. In the IL-23-stimulated kit225 T cell assay, Tyk2-IN-3 inhibits the stimulated response with an IC50 of 485±143 nM (n=3)[1].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9207 mL 9.6037 mL 19.2075 mL
5 mM 0.3841 mL 1.9207 mL 3.8415 mL
10 mM 0.1921 mL 0.9604 mL 1.9207 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

520.63

Formula

C₂₅H₂₄N₆O₃S₂

CAS No.

1779493-12-7

SMILES

CN1C=NC2=C1C(N=C(C3=CC=CC([[email protected]@H](C)NC(C4=C(S(=O)(C)=O)C=CC=C4)=O)=C3)S5)=C5N=C2NC

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Inquiry Online

Your information is safe with us. * Required Fields.

Product name

 

Salutation

Applicant name *

 

Email address *

Phone number *

 

Organization name *

Country or Region *

 

Requested quantity *

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Tyk2-IN-3
Cat. No.:
HY-18709
Quantity:

Tyk2-IN-3

Cat. No.: HY-18709