JAK3
JAK3 is a member of the Janus kinase family of non-receptor tyrosine kinases that transduce cytokine receptor signals to STAT transcription factors. It is distinguished from JAK1, JAK2 and TYK2 by its restricted expression, being found mainly in lymphoid cells, and by its selective association with the common gamma chain (γc, IL2RG) subunit shared by receptors for interleukin-2, -4, -7, -9, -15 and -21. This exclusive partnership links JAK3 to lymphocyte proliferation and development. Consequently, JAK3 loss-of-function mutations cause autosomal recessive T-negative, B-negative severe combined immunodeficiency (SCID). JAK3 is also targeted by immunosuppressive drugs: tofacitinib inhibits it alongside JAK1, and selective JAK3 inhibitors such as ritlecitinib treat alopecia areata and rheumatoid arthritis.
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JAK3 Recombinant Proteins (1)
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
