2. PROTAC Epigenetics
  3. Molecular Glues Ligands for E3 Ligase Histone Acetyltransferase
  4. BMS-986470

BMS-986470, a HbF-activating CRBN E3 ligase modulator (CELMoD), is an orally active dual molecular glue degrader targeting ZBTB7A and WIZ. BMS-986470 has potent γ-globin induction activity. BMS-986470 can be used for sickle cell disease (SCD) research.

For research use only. We do not sell to patients.

BMS-986470

BMS-986470 Chemical Structure

CAS No. : 3036554-12-5

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Based on 1 publication(s) in Google Scholar

Other Forms of BMS-986470:

BMS-986470 Related Antibodies

Top Publications Citing Use of Products

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CBP/p300 GCN5/PCAF TIP60 MOZ/MORF HBO1

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Description

BMS-986470, a HbF-activating CRBN E3 ligase modulator (CELMoD), is an orally active dual molecular glue degrader targeting ZBTB7A and WIZ. BMS-986470 has potent γ-globin induction activity. BMS-986470 can be used for sickle cell disease (SCD) research[1].

In Vivo

BMS-986470 does not affect human erythroblast differentiation and demonstrates a signicant doseependent decrease in hZBTB7A and hWIZ protein, along with an increase in F-ells and γ-globin expression in a murine model of human erythropoiesis[1].
BMS-986470 (daily for 16 days) induces dose-dependently degradation of WIZ and ZBTB7A, along with an increase in circulating immature erythrocytes, and increased HBG1/2 transcript, γ-globin protein and erythroid progenitor markers in the peripheral blood and bone marrow in healthy cynomolgus monkeys[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

523.54

Formula

C29H25N5O5
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

CC1=NC=CC(C2=CC3=C(N(C(CC3)=O)C)C=C2NC4=CC=CC5=C4C(N(C5=O)[C@H]6CCC(NC6=O)=O)=O)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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BMS-986470 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BMS-9864703036554-12-5BMS986470BMS 986470Molecular GluesLigands for E3 LigaseHistone AcetyltransferaseE3 ligase-recruiting MoietyHATsHATMolecular glue degraderCRBN E3 ligase modulatorCELMoDHbF-activatingHUDEP-2 cellsγ-globinSickle cell diseaseSCDInhibitorinhibitorinhibit

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