2. Others
  3. Drug Isomer
  4. (R)-BMS-986470

(R)-BMS-986470 is the enantiomer of BMS-986470 (HY-175742). BMS-986470, a HbF-activating CRBN E3 ligase modulator (CELMoD), is an orally active dual molecular glue degrader targeting ZBTB7A and WIZ.

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(R)-BMS-986470

(R)-BMS-986470 Chemical Structure

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in DMSO In-stock
Solid
5 mg In-stock
10 mg In-stock
50 mg   Get quote  
100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

Other Forms of (R)-BMS-986470:

(R)-BMS-986470 Related Antibodies

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Description

(R)-BMS-986470 is the enantiomer of BMS-986470 (HY-175742). BMS-986470, a HbF-activating CRBN E3 ligase modulator (CELMoD), is an orally active dual molecular glue degrader targeting ZBTB7A and WIZ[1].

Molecular Weight

523.54

Formula

C29H25N5O5
Appearance

Solid

Color

White to yellow

SMILES

CC1=NC=CC(C2=CC3=C(N(C(CC3)=O)C)C=C2NC4=CC=CC5=C4C(N(C5=O)[C@@H]6CCC(NC6=O)=O)=O)=C1
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Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (191.01 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9101 mL 9.5504 mL 19.1007 mL
5 mM 0.3820 mL 1.9101 mL 3.8201 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9101 mL 9.5504 mL 19.1007 mL 47.7518 mL
5 mM 0.3820 mL 1.9101 mL 3.8201 mL 9.5504 mL
10 mM 0.1910 mL 0.9550 mL 1.9101 mL 4.7752 mL
15 mM 0.1273 mL 0.6367 mL 1.2734 mL 3.1835 mL
20 mM 0.0955 mL 0.4775 mL 0.9550 mL 2.3876 mL
25 mM 0.0764 mL 0.3820 mL 0.7640 mL 1.9101 mL
30 mM 0.0637 mL 0.3183 mL 0.6367 mL 1.5917 mL
40 mM 0.0478 mL 0.2388 mL 0.4775 mL 1.1938 mL
50 mM 0.0382 mL 0.1910 mL 0.3820 mL 0.9550 mL
60 mM 0.0318 mL 0.1592 mL 0.3183 mL 0.7959 mL
80 mM 0.0239 mL 0.1194 mL 0.2388 mL 0.5969 mL
100 mM 0.0191 mL 0.0955 mL 0.1910 mL 0.4775 mL
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(R)-BMS-986470 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(R)-BMS-986470Drug IsomerenantiomerInhibitorinhibitorinhibit

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