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Results for "

HATs

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Histone Acetyltransferase (30) Angiotensin Receptor (1) Apoptosis (5) Autophagy (1) Bacterial (1) Cholinesterase (ChE) (1) Endogenous Metabolite (1) Endothelin Receptor (1) Epigenetic Reader Domain (4) Ferroptosis (1) GSK-3 (1) Influenza Virus (1) JAK (1) Keap1-Nrf2 (1) Mitophagy (1) Parasite (11) Phosphodiesterase (PDE) (1) PROTACs (1) Proteasome (1) Small Interfering RNA (siRNA) (1) STAT (1) YAP (2)
By Research Areas:	Cancer (35) Cardiovascular Disease (1) Infection (12) Inflammation/Immunology (4) Metabolic Disease (2)

By Targets:

Histone Acetyltransferase (30)

Angiotensin Receptor (1)

Apoptosis (5)

Autophagy (1)

Bacterial (1)

Cholinesterase (ChE) (1)

Endogenous Metabolite (1)

Endothelin Receptor (1)

Epigenetic Reader Domain (4)

Ferroptosis (1)

GSK-3 (1)

Influenza Virus (1)

JAK (1)

Keap1-Nrf2 (1)

Mitophagy (1)

Parasite (11)

Phosphodiesterase (PDE) (1)

PROTACs (1)

Proteasome (1)

Small Interfering RNA (siRNA) (1)

STAT (1)

YAP (2)

By Research Areas:

Cancer (35)

Cardiovascular Disease (1)

Infection (12)

Inflammation/Immunology (4)

Metabolic Disease (2)

Inhibitors & Agonists

Screening Libraries

Peptides

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Histone Acetyltransferase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-136285

CPI-1612	Histone Acetyltransferase	Cancer
CPI-1612 is a highly potent, orally active EP300/CBP histone acetyltransferase (HAT) inhibitor with an IC₅₀ of 8.1 nM for EP300 HAT. CPI-1612 has an anticancer activity .

HY-145386

(S,S)-CPI-1612	Others	Cancer
(S,S)-CPI-1612 is the isomer of CPI-1612 (HY-136285), and can be used as an experimental control. CPI-1612 is a highly potent, orally active EP300/CBP histone acetyltransferase (HAT) inhibitor with an IC₅₀ of 8.1 nM for EP300 HAT. CPI-1612 has an anticancer activity .

HY-136285A

(R,R)-CPI-1612	Others	Cancer
(R,R)-CPI-1612 is the isomer of CPI-1612 (HY-136285), and can be used as an experimental control. CPI-1612 is a highly potent, orally active EP300/CBP histone acetyltransferase (HAT) inhibitor with an IC₅₀ of 8.1 nM for EP300 HAT. CPI-1612 has an anticancer activity .

HY-149257

HAT-SIL-TG-1&AT	JAK STAT	Cancer
HAT-SIL-TG-1&AT is a Janus tyrosine kinase (JAK) inhibitor with antitumor effects. HAT-SIL-TG-1&AT is the hypoxia-activated prodrug, witch inhibits JAK-STAT signaling in tumor tissue. And HAT-SIL-TG-1&AT inhibits HEL cells proliferation and downregulated phosphorylated STAT3/5 under hypoxic conditions .

HY-155024

HAT-IN-8

Parasite Infection

HAT-IN-8 (Compound 38) is a BBB-penetrable T. brucei inhibitor (EC₅₀: 0.18 μM). HAT-IN-8 can be used for the research of Human African trypanosomiasis .

HAT-IN-8	Parasite	Infection
HAT-IN-8 (Compound 38) is a BBB-penetrable T. brucei inhibitor (EC₅₀: 0.18 μM). HAT-IN-8 can be used for the research of Human African trypanosomiasis .

HY-152241

DS-9300	Histone Acetyltransferase	Cancer
DS-9300 is a potent, orally active, selective EP300/CBP HAT inhibitor with an IC₅₀ value of 28 nM. DS-9300 has anticancer activity and can be used in prostate cancer disease research .

HY-162128

Antitumor agent-130	Histone Acetyltransferase	Cancer
Antitumor agent-130 (Compound 7b) is a p300 histone acetyltransferases (HAT) inhibitor with an IC₅₀ of 1.51 μM. Antitumor agent-130 combinates with doxorubicin (HY-15142A) can significantly inhibit tumor growth and invasion in vitro and in vivo .

HY-120290

PU141	Histone Acetyltransferase	Cancer
PU141 is a selected pyridoisothiazolone *HAT* inhibitor. PU141 is selective toward CBP and p300. PU141 induces cellular histone hypoacetylation and inhibits growth of several neoplastic cell lines originating from different tissues. Anticancer activity .

HY-13801

Fexinidazole HOE 239	Parasite	Infection
Fexinidazole (HOE 239) is an orally active, potent nitroimidazole antitrypanosomal agent. Fexinidazole shows trypanocidal activity against T. brucei subspecies and strains with IC₅₀s of 0.7-3.3 μM (0.2-0.9 μg/ml). Fexinidazol has the potential for human sleeping sickness (HAT) caused by infection with T. brucei .

HY-W013274

CPTH2	Histone Acetyltransferase Apoptosis	Cancer
CPTH2 is a potent histone acetyltransferase (HAT) inhibitor. CPTH2 selectively inhibits the acetylation of histone H3 by Gcn5. CPTH2 induces apoptosis and decreases the invasiveness of a clear cell renal carcinoma (ccRCC) cell line through the inhibition of acetyltransferase p300 (KAT3B) .

HY-W013274A

CPTH2 hydrochloride	Histone Acetyltransferase Apoptosis	Cancer
CPTH2 hydrochloride is a potent histone acetyltransferase (HAT) inhibitor. CPTH2 hydrochloride selectively inhibits the acetylation of histone H3 by Gcn5. CPTH2 hydrochloride induces apoptosis and decreases the invasiveness of a clear cell renal carcinoma (ccRCC) cell line through the inhibition of acetyltransferase p300 (KAT3B) .

HY-103669

HAT-IN-1

Histone Acetyltransferase Cancer

HAT-IN-1 is an inhibitor of HAT, used in the research of cancer.

HAT-IN-1	Histone Acetyltransferase	Cancer
HAT-IN-1 is an inhibitor of *HAT*, used in the research of cancer.

HY-107569

Garcinol 1 Publications Verification	Cholinesterase (ChE) Histone Acetyltransferase Apoptosis Endogenous Metabolite	Inflammation/Immunology Cancer
Garcinol, a polyisoprenylated benzophenone harvested from Garcinia indica, exerts anti-cholinesterase properties towards acetyl cholinesterase (AChE) and butyrylcholinesterase (BChE) with IC₅₀s of 0.66 µM and 7.39 µM, respectively . Garcinol also inhibits histone acetyltransferases (HATs, IC₅₀= 7 μM) and p300/CPB-associated factor (PCAF, IC₅₀ = 5 μM). Garcinol has anti-inflammatory and anti-cancer activity .

HY-146277

CBP/p300-IN-19	Histone Acetyltransferase	Cancer
CBP/p300-IN-19 is a potent p300/CBP HAT inhibitor with IC₅₀s of 1.4, 2.2, >100, >100 µM for p300-HAT, CBP-HAT, PCAF, Myst3, respectively. CBP/p300-IN-19 shows antitumor activity .

HY-154944

JG-2016

Histone Acetyltransferase Cancer

JG-2016 is a potent inhibitor of histone acetyltransferase 1 (HAT1), with an IC₅₀ of 14.8 μM in the HAT1 acetylation assays .

JG-2016	Histone Acetyltransferase	Cancer
JG-2016 is a potent inhibitor of histone acetyltransferase 1 (HAT1), with an IC₅₀ of 14.8 μM in the HAT1 acetylation assays .

HY-Q40175

Antitrypanosomal agent 9	Parasite	Infection
Antitrypanosomal agent 9 (compound 1) is a potent antitrypanosomal agent. Antitrypanosomal agent 9 shows inhibitory activity against T. b. brucei, with an IC₅₀ of 1.15 μM. Antitrypanosomal agent 9 can be used for human African trypanosomiasis (HAT) research .

HY-146277A

CBP/p300-IN-19 hydrochloride	Histone Acetyltransferase	Cancer
CBP/p300-IN-19 hydrochloride is a potent and selective p300/CBP HAT inhibitor with IC₅₀s of 1.4, 2.2, >100, >100 µM for p300-HAT, CBP-HAT, PCAF, Myst3, respectively. CBP/p300-IN-19 hydrochloride shows antitumor activity .

HY-151195

20S Proteasome-IN-4	Proteasome Parasite	Infection
20S Proteasome-IN-4 (Compound 7) is a brain-penetrant, parasite-selective, orally active 20S proteasome inhibitor with an IC₅₀ of 6.3 nM against T. b. brucei 20S proteasome. 20S Proteasome-IN-4 can be used for the research of human African trypanosomiasis (HAT) .

HY-RS06012

HAT1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
HAT1 Human Pre-designed siRNA Set A contains three designed siRNAs for HAT1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HAT1 Human Pre-designed siRNA Set A HAT1 Human Pre-designed siRNA Set A

HY-124960

CTPB

3 Publications Verification

Histone Acetyltransferase Cancer

CTPB is a good activator of p300 histone acetyl transferase (HAT) enzyme .

CTPB 3 Publications Verification	Histone Acetyltransferase	Cancer
CTPB is a good activator of p300 histone acetyl transferase (HAT) enzyme .

HY-139149

NiCur	Histone Acetyltransferase	Cancer
NiCur is a potent and selective CBP histone acetyltransferase (HAT) inhibitor with an IC₅₀ value of 0.35 μΜ. NiCur, which blocks CBP HAT activity and downregulates p53 activation upon genotoxic stress. NiCur can be used for performing mechanistic studies without affecting the expression of target proteins .

HY-143441

CBP/p300-IN-17	Histone Acetyltransferase	Cancer
CBP/p300-IN-17 (compound 7) is a potent EP300/CBP HAT inhibitor with IC₅₀s of 0.18, 0.69 µM for HAT EP300 and LK2 H3K27, respectively .

HY-143442

CBP/p300-IN-18	Histone Acetyltransferase	Cancer
CBP/p300-IN-18 (compound 8) is a potent EP300/CBP HAT inhibitor with IC₅₀s of 0.056, 0.46 µM for HAT EP300 and LK2 H3K27, respectively .

HY-143440

CBP/p300-IN-16	Histone Acetyltransferase	Cancer
CBP/p300-IN-16 (compound 1) is a potent EP300/CBP HAT inhibitor with IC₅₀s of 0.61, 2.24 µM for HAT EP300 and LK2 H3K27, respectively .

HY-N9859

6,6'-Di-O-sinapoylsucrose

Others Inflammation/Immunology

6,6'-Di-O-sinapoylsucrose is a sucrose ester hat can be found in cynanchum amplexicaule .

6,6'-Di-O-sinapoylsucrose	Others	Inflammation/Immunology
6,6'-Di-O-sinapoylsucrose is a sucrose ester hat can be found in cynanchum amplexicaule .

HY-147290

NSC 694623	Histone Acetyltransferase	Cancer
NSC 694623 is a potent histone acetyltransferase (HAT) inhibitor with an IC₅₀ value of 15.9 μM for recombinant HAT p300/CBP-associated factor (PCAF). NSC 694623 has antiproliferative activity against certain cancer cells. NSC 694623 can be used for researching anticancer .

HY-138945

SYY-B085-1

Histone Acetyltransferase Cancer

SYY-B085-1 is a histone acetyltransferase (HAT) inhibitor extracted from patent WO2019201291A1 .

SYY-B085-1	Histone Acetyltransferase	Cancer
SYY-B085-1 is a histone acetyltransferase (HAT) inhibitor extracted from patent WO2019201291A1 .

HY-131035

Lys-CoA TFA	Histone Acetyltransferase	Cancer
Lys-CoA TFA is a selective p300 histone acetyltransferase (HAT) inhibitor (IC₅₀=50-500 nM). Lys-CoA TFA displays >100-fold selectivity for p300 over PCAF (IC₅₀=200 μM). Lys-CoA TFA inhibits p300 HAT activity-dependent transcriptional activation .

HY-124696

PU139	Histone Acetyltransferase	Cancer
PU139 is a potent pan-histone acetyltransferase *(HAT)* inhibitor. PU139 blocks the HATs Gcn5, p300/CBP-associated factor (PCAF), CREB (cAMP response element-binding) protein (CBP) and p300 with IC₅₀s of 8.39, 9.74, 2.49 and 5.35 μM, respectively .

HY-155310

AF-2112

YAP Cancer

AF-2112 is a Flufenamic acid-derived TEAD inhibitor hat strongly reduce the expression of CTGF, Cyr61, Axl and NF2.
HY-155655

JC-229

Parasite Infection

JC-229 is a TbRPA1 inhibitor. JC-229 targets RPA1 in Trypanosoma brucei. JC-229 can be used for the research of Human African Trypanosomiasis (HAT) .

AF-2112	YAP	Cancer
AF-2112 is a Flufenamic acid-derived TEAD inhibitor hat strongly reduce the expression of CTGF, Cyr61, Axl and NF2.

JC-229	Parasite	Infection
JC-229 is a TbRPA1 inhibitor. JC-229 targets RPA1 in Trypanosoma brucei. JC-229 can be used for the research of Human African Trypanosomiasis (HAT) .

HY-N2020

Anacardic Acid 5+ Cited Publications Hydroginkgolic acid; Ginkgolic Acid C15:0	Histone Acetyltransferase Epigenetic Reader Domain Bacterial	Cancer
Anacardic Acid, extracted from cashew nut shell liquid, is a histone acetyltransferase inhibitor, inhibits HAT activity of p300 and PCAF, with IC₅₀s of ∼8.5 μM and ∼5 μM, respectively.

HY-114566

SPV106	Histone Acetyltransferase	Metabolic Disease
SPV106 is *histone acetylase (HAT) and GCN5-related N-acetyltransferases (GNAT)* activator. SPV106 can be used for the research of type 2 diabetes (T2D) .

HY-15887

MG 149 5+ Cited Publications Tip60 HAT inhibitor	Histone Acetyltransferase Epigenetic Reader Domain Apoptosis	Cancer
MG149 (Tip60 HAT inhibitor) is a selective and potent Tip60 inhibitor with IC₅₀ of 74 uM, similar potentcy for MOF (IC₅₀= 47 uM); little potent for PCAF and p300 (IC₅₀ >200 uM) .

HY-107455

A-485 Maximum Cited Publications 42 Publications Verification	Epigenetic Reader Domain Histone Acetyltransferase	Cancer
A-485 is a potent and selective catalytic inhibitor of p300/CBP with IC₅₀s of 9.8 nM and 2.6 nM for p300 and CBP histone acetyltransferase (HAT), respectively .

HY-19910

Acoziborole 1 Publications Verification SCYX-7158; AN5568	Parasite	Infection
Acoziborole (SCYX-7158) is an effective, safe and orally active antiprotozoal agent for the research of human african trypanosomiasis (HAT). In the *T. b. brucei* S427 strain, the MIC value for SCYX-7158 is 0.6 µg/mL .

HY-123604

TH1834	Histone Acetyltransferase Apoptosis	Cancer
TH1834 is a specific Tip60 (KAT5) histone acetyltransferase (HAT) inhibitor. TH1834 induces apoptosis and increases DNA damage in breast cancer. TH1834 does not affect the activity of related histone acetyltransferase MOF. Anticancer activity .

HY-155309

LM-41	YAP	Cancer
LM-41 is a Flufenamic acid-derived TEAD inhibitor hat strongly reduce the expression of CTGF, Cyr61, Axl and NF2. LM-41 inhibits migration of human MDA-MB-231 breast cancer cells .

HY-114953

BMS-248360	Angiotensin Receptor Endothelin Receptor	Cardiovascular Disease
BMS-248360 is a potent and orally active dual antagonist of both angiotensin II receptor (AT1) and endothelin A (ET_A) receptor, with K_is of 10 nM and 1.9 nM for hAT1 and hETA receptor, respectively. BMS-248360 displays hypertensive effects .

HY-163003

Antitrypanosomal agent 19	Parasite	Infection
Antitrypanosomal agent 19 (compound 10) is an orally available antitrypanosomal agent. Antitrypanosomal agent 19 effectively inhibits the growth of trypanosomatids T. b. brucei, T. b. gambiense and T. b. rhodesiense, mitigating the Human trypanosomiasis (HAT)-induced acute infectious toxicity in mice .

HY-N2345

Procyanidin B3	Histone Acetyltransferase	Cancer
Procyanidin B3 is a natural product, acts as a specific *HAT* inhibitor, binds to the other site of p300 instead of the active site, selectively inhibits p300-mediated androgen receptor acetylation. Procyanidin B3 has no effect on HDAC or HMT (histone methyltransferase) .

HY-N0005S

Curcumin-d6 Diferuloylmethane-d₆; Natural Yellow 3-d₆; Turmeric yellow-d₆	Keap1-Nrf2 Ferroptosis Autophagy Histone Acetyltransferase Epigenetic Reader Domain Mitophagy Influenza Virus	Infection Metabolic Disease Inflammation/Immunology
Curcumin-d₆is a deuterium labeled Curcumin (Turmeric yellow). Curcumin (Turmeric yellow) is a natural phenolic compound with diverse pharmacologic effects including anti-inflammatory, antioxidant, antiproliferative and antiangiogenic activities. Curcumin is an inhibitor of p300 histone acetylatransferase (HATs) and also shows inhibitory effects on NF-κB and MAPKs.

HY-155025

Antitrypanosomal agent 14	Parasite GSK-3	Infection
Antitrypanosomal agent 14 (Compound 1) is a T. brucei inhibitor (EC₅₀: 0.47 μM). Antitrypanosomal agent 14 inhibits TbGSK3 with an IC₅₀ of 12 μM. Antitrypanosomal agent 14 can be used for the research of Human African trypanosomiasis .

HY-147261

B026	Histone Acetyltransferase	Cancer
B026 is a selective, potent, orally active p300/CBP histone acetyltransferase (HAT) inhibitor with IC₅₀ values of 1.8 nM and 9.5 nM for p300 and CBP enzyme, respectively. B026 has anticancer activity for androgen receptor-positive (AR+) prostate cancer cell lines .

HY-W015239

KAT8-IN-1	Others	Inflammation/Immunology Cancer
KAT8-IN-1 is a lysine (K) acetyltransferase 8 (KAT8) inhibitor, with IC₅₀s of 141 μM (KAT8), 221 μM (KAT2B), 106 μM (KAT3B), respectively. KAT8 inhibits histone acetyltransferases (HATs), and could result in disease states, such as cancer or inflammatory diseases .

HY-147288

NSC 694621	Histone Acetyltransferase	Cancer
NSC 694621 is a potent PCAF inhibitor, with an IC₅₀ of 5.71 µM (PCAF/H3_1-21). NSC 694621 exhibits good activity of inhibiting the proliferation of cancer cells .

HY-147289

NSC 698600	Histone Acetyltransferase	Cancer
NSC 698600 is a potent PCAF inhibitor, with IC₅₀ of 6.51 µM (PCAF/H3_1-21). NSC 698600 exhibits good activity of inhibiting the proliferation of cancer cells .

HY-136637

NPD-001	Phosphodiesterase (PDE) Parasite	Infection
NPD-001 is a potent Trypanosoma brucei phosphodiesterases TbrPDEB1 and TbrPDEB2 inhibitor, with IC₅₀ values of 4 and 3 nM, respectively. NPD-001 also inhibits human PDEs (phosphodiesterases). NPD-001 shows good anti trypanosomal activity, with an IC₅₀ of 80 nM .

HY-155732

NPD-2975	Parasite	Infection
NPD-2975 (compound 30) is an orally active antitrypanosomal agent, against Human African Trypanosomiasis (HAT). NPD-2975 has low toxicity potential against human MRC-5 lung fibroblasts, and acute mouse model of T. b. brucei infection. NPD-2975 shows acceptable metabolic stability, inhibits T. b. brucei with IC₅₀0 of 70 nM in vitro. NPD-2975 also inhibits CYP enzymes resulted in IC₅₀ values of 0.16 and 0.42 μM against CYP1A2 and CYP2C19, respectively .

HY-150506

SPR7	Parasite	Infection
SPR7 (compound 7) is a potent and selective rhodesain inhibitor, with a K_i of 0.51 nM. SPR7 shows antiparasitic activity against T. b. brucei, with an EC₅₀ of 1.65 μM .

Cat. No.	Product Name	Category	Target	Chemical Structure