Antitumor agent-130
Antitumor agent-130 (Compound 7b) is a p300 histone acetyltransferases (HAT) inhibitor with an IC50 of 1.51 μM. Antitumor agent-130 combinates with doxorubicin (HY-15142A) can significantly inhibit tumor growth and invasion in vitro and in vivo.
For research use only. We do not sell to patients.
- CAS No.: 3048422-07-4
- Formula: C20H18ClNO5
- Molecular Weight:387.81
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| LNCaP | IC50 |
43.745 μM
Compound: 7b
|
Antiproliferative activity against human LNCaP cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
Antiproliferative activity against human LNCaP cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
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[PMID: 38215590] |
| MCF-10A | IC50 |
>50 μM
Compound: 7b
|
Antiproliferative activity against human MCF-10A cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
Antiproliferative activity against human MCF-10A cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
|
[PMID: 38215590] |
| MCF7 | IC50 |
17.34 μM
Compound: 7b
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Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
|
[PMID: 38215590] |
| MCF7 | IC50 |
17.34 μM
Compound: 7b
|
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay
|
[PMID: 38215590] |
| PANC-1 | IC50 |
>50 μM
Compound: 7b
|
Antiproliferative activity against human PANC-1 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
Antiproliferative activity against human PANC-1 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
|
[PMID: 38215590] |
Chemical Information
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CAS No. 3048422-07-4
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Molecular Weight 387.81
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Formula C20H18ClNO5
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SMILES
COC1=C(OC)C=C(C=C(C2=CC(OCO3)=C3C=C2OCC4)[N+]4=C5)C5=C1.[Cl-]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antitumor agent-130 Related Classifications
HY-162128 Related Classifications
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